There is no curative treatment for migraine, although there does exist various options for pharmacological treatment.Drug treatment withβ-adrenoceptor blockers,calcium antagonists,or other agents has been shown to re...There is no curative treatment for migraine, although there does exist various options for pharmacological treatment.Drug treatment withβ-adrenoceptor blockers,calcium antagonists,or other agents has been shown to reduce the frequency of migraine attacks;however,the success of treatment is usually modest.Acupuncture has been increasingly used as adjunctive treatment in primary headache syndromes and there is growing evidences from clinical trials that it might be beneficial in the treatment of migraine,with an effect size comparable to pharmacologic treatment.Despite its popularity,there’s still some controversy as to the difference between the specific and the nonspecific effects of acupuncture.展开更多
Objective:Metabolic disorders are markedly common in women with polycystic ovary syndrome(PCOS),and nonalcoholic fatty liver disease(NAFLD)is observed in 30%-55%of all PCOS patients.Many studies have reported that aut...Objective:Metabolic disorders are markedly common in women with polycystic ovary syndrome(PCOS),and nonalcoholic fatty liver disease(NAFLD)is observed in 30%-55%of all PCOS patients.Many studies have reported that autophagy and apoptosis,which are closely related to mitochondrial function,play important roles in the development of NAFLD.Therefore,in this study,we aimed to explore the role of mitochondrial dysfunction caused by liver apoptosis and autophagy imbalance in the development of NAFLD in a PCOS mouse model.Methods:We used a dihydrotestosterone(DHT)-induced PCOS model to mimic the pathological process of hyperandrogenism.Hematoxylin and eosin and Oil Red O staining assays were used to observe the pathological changes in the liver.Western blotting and quantitative real-time polymerase chain reaction were used to perform mitochondrion-related assays.Results:Hepatic steatosis and different degrees of inflammation were observed in the DHT-treated mice.The expression of molecules involved in the respiratory chain and aerobic respiration process was altered.The levels of the key molecules associated with apoptosis and autophagy were abnormal.Conclusions:Androgens may play a role in the process of hepatic steatosis development by affecting mitochondrial function and subsequently inducing apoptosis and autophagy.Such phenomena might be involved in the pathogenesis of NAFLD in women with PCOS.展开更多
文摘There is no curative treatment for migraine, although there does exist various options for pharmacological treatment.Drug treatment withβ-adrenoceptor blockers,calcium antagonists,or other agents has been shown to reduce the frequency of migraine attacks;however,the success of treatment is usually modest.Acupuncture has been increasingly used as adjunctive treatment in primary headache syndromes and there is growing evidences from clinical trials that it might be beneficial in the treatment of migraine,with an effect size comparable to pharmacologic treatment.Despite its popularity,there’s still some controversy as to the difference between the specific and the nonspecific effects of acupuncture.
基金This work was supported by the National Natural Science Foundation of China(No.81673766 and 81973945 to YF,No.81572555 to XL)the Chinese Special Fund for Postdocs(No.2014T70392)+1 种基金the Swedish Medical Research Council(No.10380)the Swedish Federal Government under the LUA/ALF agreement(No.ALFGBG-147791 to HB and LS).
文摘Objective:Metabolic disorders are markedly common in women with polycystic ovary syndrome(PCOS),and nonalcoholic fatty liver disease(NAFLD)is observed in 30%-55%of all PCOS patients.Many studies have reported that autophagy and apoptosis,which are closely related to mitochondrial function,play important roles in the development of NAFLD.Therefore,in this study,we aimed to explore the role of mitochondrial dysfunction caused by liver apoptosis and autophagy imbalance in the development of NAFLD in a PCOS mouse model.Methods:We used a dihydrotestosterone(DHT)-induced PCOS model to mimic the pathological process of hyperandrogenism.Hematoxylin and eosin and Oil Red O staining assays were used to observe the pathological changes in the liver.Western blotting and quantitative real-time polymerase chain reaction were used to perform mitochondrion-related assays.Results:Hepatic steatosis and different degrees of inflammation were observed in the DHT-treated mice.The expression of molecules involved in the respiratory chain and aerobic respiration process was altered.The levels of the key molecules associated with apoptosis and autophagy were abnormal.Conclusions:Androgens may play a role in the process of hepatic steatosis development by affecting mitochondrial function and subsequently inducing apoptosis and autophagy.Such phenomena might be involved in the pathogenesis of NAFLD in women with PCOS.
