The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems

Vascular endothelial growth factor receptor 2(VEGFR-2)and neuropilin-1(NRP-1)are two prominent antiangiogenic targets.They are highly expressed on vascular endothelial cells and some tumor cells.Therefore,targeting VEGFR-2 and NRP-1 may be a potential antiangiogenic and antitumor strategy.A7R,a peptide with sequence of Ala-Thr-Trp-Leu-Pro-Pro-Arg that was found by phage display of peptide libraries,can preferentially target VEGFR-2 and NRP-1 and destroy the binding between vascular endothelial growth factor 165(VEGF165)and VEGFR-2 or NRP-1.This peptide is a new potent inhibitor of tumor angiogenesis and a targeting ligand for cancer therapy.This review describes the discovery,function and mechanism of the action of A7R,and further introduces the applications of A7R in antitumor angiogenic treatments,tumor angiogenesis imaging and targeted drug delivery systems.In this review,strategies to deliver different drugs by A7R-modified liposomes and nanoparticles are highlighted.A7R,a new dual targeting ligand of VEGFR-2 and NRP-1,is expected to have efficient therapeutic or targeting roles in tumor drug delivery.

Studies on plasma-activated perilla seed oil:Diagnosis,optimisation,and validation of reactive species

Recently,the applications of cold atmospheric plasma(CAP)in liquid treatment have attracted increasing attention owing to its excellent medical efficacy.It has been proved that CAP can effectively enhance the biological activity of vegetable oils due to the generation of reactive species.Optimising the reactor parameter is an important approach to regulate reactive species in plasma-activated oil to obtain better biological effects.In this study,a self-made jet array driven by a pulsed power supply was used to generate large-area plasma to irradiate perilla seed oil(PSO),with the formation of plasmaactivated perilla seed oil(PAPSO).By means of laser-induced fluorescence and chemical titration,the relative density of hydroxyl radical radical in plasma jet,as well as the activity of PAPSO were measured under different discharge parameters,and realised the control of the activity of PAPSO.In vitro experiments showed that PAPSO significantly enhanced its ability to inhibit cancer cells proliferation and induce apoptosis after plasma treatment,which provides a reference for cancer treatment.This study is helpful to further understand the influence of plasma dose effect on the activity of media and provide guidance for related plasma medical applications.