Effect of hydrophilic or hydrophobic interactions on the self-assembly behavior and micro-morphology of a collagen mimetic peptide

Peptide self-assembles with bionic properties have been widely utilized for bioactive drugs and biomedical materials.Collagen mimetic peptide(CMP)gains more attention due to its unique advantages in biosecurity and function.Unfortunately,the self-assembly mechanism of CMP,particularly the effect of intermolecular forces on its self-assembly behavior and morphology,is still unrecognized.Herein,the hydrophilic glycidol(GCD)and hydrophobic Y-glycidyl ether oxypropyl trimethoxysilane(GLH)were grafted onto the side chains of CMP through the ring-opening reaction(GCD/CMP,GLH/CMP).Subsequently,the effects of hydrophilic and hydrophobic interactions on the self-assembly behavior and morphology of CMP were further studied.The results substantiated that the GCD/CMP and GLH/CMP self-assembly followed“nucleation-growth”mechanism,and the supererogatory hydrophilic and hydrophobic groups prolonged the nucleation and growth time of CMP self-assembly.Noted that the hydrophilic interaction had stronger driving effects than hydrophobic interaction on the self-assembly of CMP.The GCD/CMP and GLH/CMP self-assembles exhibited fibrous 3D network and microsphere morphology,respectively.Furthermore,the GLH/CMP self-assembles had better resistance to degradation.Consequently,the microtopography and degradation properties of CMP self-assembles could be controlled by the hydrophilic and hydrophobic interactions between CMP,which would further provide a way for subsequent purposeful design of biomedical materials.

Electrochemical biomaterials for self-powered implantable“tissue batteries”:A tutorial review

Currently,due to improvements in living standards,people are paying more attention to all-around disease prevention and health care.Self-powered implantable“tissue batteries”integrated with electrochemical materials are essential for disease prevention,diagnosis,treatment,postoperative therapy,and healthcare applications.We propose and define new concepts of“tissue batteries”-self-powered tissue batteries(SPTBs)-are flexible self-powered implantable systems or platforms based on electroactive biomaterials,acting at the interface of biological tissue.Based on the electrical phenomenon of living organisms in life activities,there has been an increased attention to SPTBs for tissue repair promotion.SPTBs take advantages of both the preeminent biocompatibility of biomaterials and the promotion of time-honored electrical stimulation therapy for tissue recovery,which are very promising for human illness treatment.However,studies on clinical applications of SPTBs are impeded by a lack of comprehensive cognitive assessment of SPTBs.Herein,SPTBs for life and health applications are comprehensively reviewed.First,electrochemical materials and their across-the-board applications for several types of SPTBs are introduced and compared with regard to disease prevention,diagnosis,precision therapy,and personalized health monitoring.Then,the potential mechanisms for SPTBs for tissue repair promotion are discussed.Finally,the prospective challenges are summarized and recommendations for future research are provided.This review elucidates on the significance and versatility of SPTBs for various medical applications.

Advances on the modification and biomedical applications of acellular dermal matrices

Acellular dermal matrix(ADM)is derived from natural skin by removing the entire epidermis and the cell components of dermis,but retaining the collagen components of dermis.It can be used as a therapeutic alternative to"gold standard"tissue grafts and has been widely used in many surgical fields,since it possesses affluent predominant physicochemical and biological characteristics that have attracted the attention of researchers.Herein,the basic science of biologics with a focus on ADMs is comprehensively described,the modification principles and technologies of ADM are discussed,and the characteristics of ADMs and the evidence behind their use for a variety of reconstructive and prosthetic purposes are reviewed.In addition,the advances in biomedical applications of ADMs and the common indications for use in reconstructing and repairing wounds,maintaining homeostasis in the filling of a tissue defect,guiding tissue regeneration,and delivering cells via grafts in surgical applications are thoroughly analyzed.This review expectedly promotes and inspires the emergence of natural raw collagen-based materials as an advanced substitute biomaterial to autologous tissue transplantation.

Advances on the modification and biomedical applications of acellular dermal matrices

Acellular dermal matrix(ADM)is derived from natural skin by removing the entire epidermis and the cell components of dermis,but retaining the collagen components of dermis.It can be used as a therapeutic alternative to“gold standard”tissue grafts and has been widely used in many surgical fields,since it possesses affluent predominant physicochemical and biological characteristics that have attracted the attention of researchers.Herein,the basic science of biologics with a focus on ADMs is comprehensively described,the modification principles and technologies of ADM are discussed,and the characteristics of ADMs and the evidence behind their use for a variety of reconstructive and prosthetic purposes are reviewed.In addition,the advances in biomedical applications of ADMs and the common indications for use in reconstructing and repairing wounds,maintaining homeostasis in the filling of a tissue defect,guiding tissue regeneration,and delivering cells via grafts in surgical applications are thoroughly analyzed.This review expectedly promotes and inspires the emergence of natural raw collagen-based materials as an advanced substitute biomaterial to autologous tissue transplantation.

Nature-skin-derived multi-responsive e-skin as on-demand drug-delivery system facilitated melanoma postoperative therapy

An ideal strategy for integrated melanoma treatment involves the pursuit of multifunctional biomaterials that possess adjuvant therapy functions,enabling full-scale postoperative relapse prevention,wound healing,and real-time postoperative surveillance.The simulation of electronic skin(e-skin),which emulates the mechanical properties and functions of natural skin,holds significant potential for broad biomedical applications.Herein,a novel multi-responsive controlled-release e-skin(PADM-MX-Ag-Si@Dox)was developed using natural porcine dermal matrix,MXene nanosheets,silver nanowires(AgNWs),and mesoporous hollow silica microspheres(TSOHSiO_(2)@Dox)for drug-loading.The resulting e-skin exhibited temperature-,pH-,and electric-responsiveness due to the incorporation of TSOHSiO_(2)@Dox microspheres,which allowed for on-demand controlled-release of Dox.The biomimetic structure of porcine acellular dermal matrix(PADM)can significantly accelerate the wound healing process under the synergistic effect of electrical stimulation(ES).PADM-MX-Ag-Si@Dox has demonstrated remarkable antimicrobial and electrophysiological activities,thereby establishing a robust basis for enhancing wound healing and facilitating real-time postoperative tumor surveillance.Extensive in vitro and in vivo investigations have substantiated that the combined utilization of PADM-MX-Ag-Si@Dox and ES results in a proactive amalgamation of melanoma postoperative relapse prevention,wound healing,and real-time postoperative surveillance,thereby establishing a potent therapeutic approach for postoperative cancer adjuvant therapy and paving the way for novel precision medical care.