Understanding material-protein interactions is the basis for regulating material-blood interactions,which is a common topic of interest for medical material developers.In recent years,researchers have conducted extens...Understanding material-protein interactions is the basis for regulating material-blood interactions,which is a common topic of interest for medical material developers.In recent years,researchers have conducted extensive studies on(1)the structural charac-teristics of the plasma protein adsorption layer on the material surface,including the evolution of the protein adsorption layer and its typical binary structure.(2)Influence factors of the protein adsorption layer formation include protein factors(e.g.,isoelectric point,structural stability),material factors(e.g.,wettability,surface charge,morphology,size),and environmental factors.(3)Effects of some common plasma proteins in the protein adsorption layer on material-blood interactions.Here,we review the important research results in this field,hoping to provide a reference for future development of advanced blood contact materials.展开更多
Titanium dioxide(TiO2)has a long history of application in blood contact materials,but it often suffers from insufficient anticoagulant properties.Recently,we have revealed the photocatalytic effect of TiO2 also induc...Titanium dioxide(TiO2)has a long history of application in blood contact materials,but it often suffers from insufficient anticoagulant properties.Recently,we have revealed the photocatalytic effect of TiO2 also induces anticoagulant properties.However,for long-term vascular implant devices such as vascular stents,besides anticoagulation,also anti-inflammatory,anti-hyperplastic properties,and the ability to support endothelial repair,are desired.To meet these requirements,here,we immobilized silver nanoparticles(AgNPs)on the surface of TiO2 nanotubes(TiO2-NTs)to obtain a composite material with enhanced photo-induced anticoagulant property and improvement of the other requested properties.The photo-functionalized TiO2-NTs showed protein-fouling resistance,causing the anticoagulant property and the ability to suppress cell adhesion.The immobilized AgNPs increased the photocatalytic activity of TiO2-NTs to enhances its photo-induced anticoagulant property.The AgNP density was optimized to endow the TiO2-NTs with anti-inflammatory property,a strong inhibitory effect on smooth muscle cells(SMCs),and low toxicity to endothelial cells(ECs).The in vivo test indicated that the photofunctionalized composite material achieved outstanding biocompatibility in vasculature via the synergy of photo-functionalized TiO2-NTs and the multifunctional AgNPs,and therefore has enormous potential in the field of cardiovascular implant devices.Our research could be a useful reference for further designing of multifunctional TiO2 materials with high vascular biocompatibility.展开更多
基金National Natural Science Foundation of China,Grant/Award Numbers:31570957,21875092National Key Research and Development Program of China,Grant/Award Numbers:2019YFA0112000,2017YFB0702504。
文摘Understanding material-protein interactions is the basis for regulating material-blood interactions,which is a common topic of interest for medical material developers.In recent years,researchers have conducted extensive studies on(1)the structural charac-teristics of the plasma protein adsorption layer on the material surface,including the evolution of the protein adsorption layer and its typical binary structure.(2)Influence factors of the protein adsorption layer formation include protein factors(e.g.,isoelectric point,structural stability),material factors(e.g.,wettability,surface charge,morphology,size),and environmental factors.(3)Effects of some common plasma proteins in the protein adsorption layer on material-blood interactions.Here,we review the important research results in this field,hoping to provide a reference for future development of advanced blood contact materials.
基金the National Natural Science Foundation of China(nos.31870958,31700821,and 81771988).
文摘Titanium dioxide(TiO2)has a long history of application in blood contact materials,but it often suffers from insufficient anticoagulant properties.Recently,we have revealed the photocatalytic effect of TiO2 also induces anticoagulant properties.However,for long-term vascular implant devices such as vascular stents,besides anticoagulation,also anti-inflammatory,anti-hyperplastic properties,and the ability to support endothelial repair,are desired.To meet these requirements,here,we immobilized silver nanoparticles(AgNPs)on the surface of TiO2 nanotubes(TiO2-NTs)to obtain a composite material with enhanced photo-induced anticoagulant property and improvement of the other requested properties.The photo-functionalized TiO2-NTs showed protein-fouling resistance,causing the anticoagulant property and the ability to suppress cell adhesion.The immobilized AgNPs increased the photocatalytic activity of TiO2-NTs to enhances its photo-induced anticoagulant property.The AgNP density was optimized to endow the TiO2-NTs with anti-inflammatory property,a strong inhibitory effect on smooth muscle cells(SMCs),and low toxicity to endothelial cells(ECs).The in vivo test indicated that the photofunctionalized composite material achieved outstanding biocompatibility in vasculature via the synergy of photo-functionalized TiO2-NTs and the multifunctional AgNPs,and therefore has enormous potential in the field of cardiovascular implant devices.Our research could be a useful reference for further designing of multifunctional TiO2 materials with high vascular biocompatibility.
