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miR-145 improves metabolic inflammatory disease through multiple pathways 被引量:12
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作者 Min He Nan Wu +21 位作者 Man Cheong Leong Weiwei Zhang Zi Ye Rumei Li Jinyang Huang Zhaoyun Zhang Lianxi Li Xiao Yao Wenbai Zhou Naijia Liu Zhihong Yang Xuehong Dong Yintao Li Lili Chen Qin Li Xuanchun Wang Jie Wen Xiaolong Zhao Bin Lu Yehong Yang Qinghua Wang Renming Hu 《Journal of Molecular Cell Biology》 SCIE CAS CSCD 2020年第2期152-162,共11页
Chronic inflammation plays a pivotal role in insulin resistance and type 2 diabetes,yet the mechanisms are not completely understood.Here,we demonstrated that serum LPS levels were significantly higher in newly diagno... Chronic inflammation plays a pivotal role in insulin resistance and type 2 diabetes,yet the mechanisms are not completely understood.Here,we demonstrated that serum LPS levels were significantly higher in newly diagnosed diabetic patients than in normal control.miR-145 level in peripheral blood mononuclear cells decreased in type 2 diabetics.LPS repressed the transcription of miR-143/145 cluster and decreased miR-145 levels.Attenuation of miR-145 activity by anti-miR-145 triggered liver inflammation and increased serum chemokines in C57BL/6 J mice.Conversely,lentivirus-mediated miR-145 overexpression inhibited macrophage infiltration,reduced body weight,and improved glucose metabolism in db/db mice.And miR-145 overexpression markedly reduced plaque size in the aorta in ApoE−/−mice.Both OPG and KLF5 were targets of miR-145.miR-145 repressed cell proliferation and induced apoptosis partially by targeting OPG and KLF5.miR-145 also suppressed NF-κB activation by targeting OPG and KLF5.Our findings provide an association of the environment with the progress of metabolic disorders.Increasing miR-145 may be a new potential therapeutic strategy in preventing and treating metabolic diseases such as type 2 diabetes and atherosclerosis. 展开更多
关键词 type 2 diabetes OSTEOPROTEGERIN Kruppel-like factor 5 MONOCYTE NF-ΚB
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Organ-specific alterations in circadian genes by vertical sleeve gastrectomy in an obese diabetic mouse model
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作者 Qiwei Shen Yeping Yang +14 位作者 Wenjuan Liu Meng Wang Yikai Shao Bo Xu Xiaolong Zhao Jinxing Zhu Rong Hua Wanzhu Jin Zhiyu Hu Jae Bum Kim Qinghua Wang Yiming Li Mengwei Zang Qiyuan Yao Zhaoyun Zhang 《Science Bulletin》 SCIE EI CAS CSCD 2017年第7期467-469,共3页
Current therapies for obesity and related complications have been shown to have limited benefits,including unsatisfactory weight loss and poor metabolic improvement.With recent developments in bariatric surgery,promis... Current therapies for obesity and related complications have been shown to have limited benefits,including unsatisfactory weight loss and poor metabolic improvement.With recent developments in bariatric surgery,promising advancements have been made in clinical and scientific research,particularly in the management of obesity and diabetes.Vertical sleeve gastrectomy(VSG)has become increasingly popular due to its safety,simplicity, 展开更多
关键词 VSG In Organ-specific alterations in circadian genes by vertical sleeve gastrectomy in an obese diabetic mouse model WAT PGC
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