A recent study by Mohanta et al.describes a new understanding of neuroimmune interactions in atherosclerosis.While atherosclerotic plaques are not innervated,ablating the sympathetic innervation to these regions atten...A recent study by Mohanta et al.describes a new understanding of neuroimmune interactions in atherosclerosis.While atherosclerotic plaques are not innervated,ablating the sympathetic innervation to these regions attenuated atherosclerosis,suggesting a potential novel therapeutic strategy.Atherosclerosis continues to be the leading cause of death in industrialized countries due to its complications such as acute myocardial infarction or stroke.The disease is the result of a complex process,consisting of sub-endothelial lipid retention,immune cell migration,proteolytic injury,altogether leading to a chronic inflammatory responses in the wall of large arteries and ultimately plaque development.2 The inner layer of the blood vessels is not innervated and hence the nervous system connects with the vessel through its most outer layer,the lamina adventitia,hereby controlling important functions including arterial blood pressure.Beyond such homeostatic control of vessel function,increasing evidence demonstrates that activation of the sympathetic nervous system can modulate the degree of arterial inflammation.展开更多
In a recent paper published in Science,Ng et al.provide seminal insights into the process through which neutrophils are reprogrammed by the tumor environment,leading to a convergent transition from different neutrophi...In a recent paper published in Science,Ng et al.provide seminal insights into the process through which neutrophils are reprogrammed by the tumor environment,leading to a convergent transition from different neutrophil states towards a unique end-stage differentiated pro-tumor phenotype.1 These findings have major translational implications as they provide potential neutrophil-related targets for tumor immunotherapy.展开更多
基金Open Access funding enabled and organized by Projekt DEALY.S.would like to acknowledge European network for research in vascular ageing(COST Action 18216)+2 种基金Dr.Robert Pfleger Foundation(grant ZUW80298)O.S.receives support from the Deutsche Forschungsgemeinschaft(SFB914 B8,SFB1009 A13,SFB1123 A6,SFB/TRR332 A2&Z1,OR465/1-1)the Else Kröner Fresenius Stiftung,the Leducq Foundation and the IZKF of the Medical Faculty of the University of Münster.
文摘A recent study by Mohanta et al.describes a new understanding of neuroimmune interactions in atherosclerosis.While atherosclerotic plaques are not innervated,ablating the sympathetic innervation to these regions attenuated atherosclerosis,suggesting a potential novel therapeutic strategy.Atherosclerosis continues to be the leading cause of death in industrialized countries due to its complications such as acute myocardial infarction or stroke.The disease is the result of a complex process,consisting of sub-endothelial lipid retention,immune cell migration,proteolytic injury,altogether leading to a chronic inflammatory responses in the wall of large arteries and ultimately plaque development.2 The inner layer of the blood vessels is not innervated and hence the nervous system connects with the vessel through its most outer layer,the lamina adventitia,hereby controlling important functions including arterial blood pressure.Beyond such homeostatic control of vessel function,increasing evidence demonstrates that activation of the sympathetic nervous system can modulate the degree of arterial inflammation.
基金The research of the authors is supported by the Deutsche Forschungsgemeinschaft(SFB-TRR 332).The figure was created with Biorender.com.
文摘In a recent paper published in Science,Ng et al.provide seminal insights into the process through which neutrophils are reprogrammed by the tumor environment,leading to a convergent transition from different neutrophil states towards a unique end-stage differentiated pro-tumor phenotype.1 These findings have major translational implications as they provide potential neutrophil-related targets for tumor immunotherapy.
