Telomeres maintain chromosome integrity.Loss of telomere function,which is attributed to progressively shortened telomeres in each round of DNA replication,induces endto-end fusion of chromosomes,anaphase bridges with...Telomeres maintain chromosome integrity.Loss of telomere function,which is attributed to progressively shortened telomeres in each round of DNA replication,induces endto-end fusion of chromosomes,anaphase bridges with subsequent chromosome breakage,and eventually leads to senescence and apoptosis in normal cells[1].In cancer cells,highly activated telomerase synthesizes telomere repeats to promote telomere elongation.展开更多
基金the Ministry of Science and Technology of the People’s Republic of China,Grant/Award Number:2020YFA0803300National Center of Technology Innovation for Biopharmaceuticals,Grant/Award Number:NCTIB2022HS02006+1 种基金Taishan Scholar Project from Shandong province,Grant/Award Number:tsqn202312174National Natural Science Foundation of China,Grant/Award Numbers:82030074,82103351,82188102。
文摘Telomeres maintain chromosome integrity.Loss of telomere function,which is attributed to progressively shortened telomeres in each round of DNA replication,induces endto-end fusion of chromosomes,anaphase bridges with subsequent chromosome breakage,and eventually leads to senescence and apoptosis in normal cells[1].In cancer cells,highly activated telomerase synthesizes telomere repeats to promote telomere elongation.
