Therapeutics are compounds,which do not always exhibit healing powers.They sometimes prevent or control roles.Many compounds,well known or less are treated as the therapeutic agents.Among them,there is a specific grou...Therapeutics are compounds,which do not always exhibit healing powers.They sometimes prevent or control roles.Many compounds,well known or less are treated as the therapeutic agents.Among them,there is a specific group of molecules named commonly as Schiff bases,chemically imines.Schiff bases are aldehyde-or ketone-like compounds in which the carbonyl group is replaced by an imine-HN=СН-or azomethine-NHN=СН-group,they are an important class of compounds for new drug development.Schiff base modifications so far proved to be very effective with increased efficacy and reduced toxicity.Therefore,many researchers have synthesized these compounds as target structures and evaluated their biological activity.The aim of this work was to present some interesting and promising examples of Schiff bases which exhibit biological activity.展开更多
The aim was to investigate the antifungal effectiveness and some of pharmacological properties of essential oils (EOs), which had not yet been thoroughly studied in the planned scope. We first evaluated MIC/MFC of six...The aim was to investigate the antifungal effectiveness and some of pharmacological properties of essential oils (EOs), which had not yet been thoroughly studied in the planned scope. We first evaluated MIC/MFC of sixteen EOs against C. albicans ATCC 10231. Then, five most active EOs were tested, using 50 clinical Candida spp. strains and additional reference C. albicans ATCC 90028 strain. The time-kill curve, carryover, post-antifungal effects (PAFE), mutant prevention concentrations, the susceptibility of reference strains to the cell wall disrupting agents and tolerance to oxidative stress, were evaluated. For these detailed studies, we chose the following four essential oils. Clove oil, Geranium oil, Lemon balm and Citronella oil, with MICs of 0.097% (v/v), resulted concentration- and time-dependent killing and may be therapeutically safe, because they do not generate resistance. The best one was Lemon balm, which caused most extended PAFE, significantly reduced tolerance to oxidative stress and increased susceptibility to Calcofluor White, Congo Red and SDS. Phytochemical analysis of these four EOs has been performed and compared;looking for the reason that Lemon balm was the best.展开更多
文摘Therapeutics are compounds,which do not always exhibit healing powers.They sometimes prevent or control roles.Many compounds,well known or less are treated as the therapeutic agents.Among them,there is a specific group of molecules named commonly as Schiff bases,chemically imines.Schiff bases are aldehyde-or ketone-like compounds in which the carbonyl group is replaced by an imine-HN=СН-or azomethine-NHN=СН-group,they are an important class of compounds for new drug development.Schiff base modifications so far proved to be very effective with increased efficacy and reduced toxicity.Therefore,many researchers have synthesized these compounds as target structures and evaluated their biological activity.The aim of this work was to present some interesting and promising examples of Schiff bases which exhibit biological activity.
基金supported by the National Research Cen-ter,Poland,Grant No.2011/01/N/NZ6/00317by University of Lodz(2012)for A.B.The authors wish to thank M.Więckowska-Szakiel for technical assistance.
文摘The aim was to investigate the antifungal effectiveness and some of pharmacological properties of essential oils (EOs), which had not yet been thoroughly studied in the planned scope. We first evaluated MIC/MFC of sixteen EOs against C. albicans ATCC 10231. Then, five most active EOs were tested, using 50 clinical Candida spp. strains and additional reference C. albicans ATCC 90028 strain. The time-kill curve, carryover, post-antifungal effects (PAFE), mutant prevention concentrations, the susceptibility of reference strains to the cell wall disrupting agents and tolerance to oxidative stress, were evaluated. For these detailed studies, we chose the following four essential oils. Clove oil, Geranium oil, Lemon balm and Citronella oil, with MICs of 0.097% (v/v), resulted concentration- and time-dependent killing and may be therapeutically safe, because they do not generate resistance. The best one was Lemon balm, which caused most extended PAFE, significantly reduced tolerance to oxidative stress and increased susceptibility to Calcofluor White, Congo Red and SDS. Phytochemical analysis of these four EOs has been performed and compared;looking for the reason that Lemon balm was the best.
