The levels of plasma norepinephrine (NE) and epinephrine (E) were determined by HPLC in 220 patients with various TCM liver syndromes, and in 96 healthy subjects as controls. The plasma NE and E contents were higher i...The levels of plasma norepinephrine (NE) and epinephrine (E) were determined by HPLC in 220 patients with various TCM liver syndromes, and in 96 healthy subjects as controls. The plasma NE and E contents were higher in patients with liver excess syndromes, including Ganqi Yujie (GQYJ 肝气郁结 ) syndrome, Ganyang Shangkang (GYSK肮阳上亢) syndrome, Ganhuo Shangyan (GHSY 肝火上炎) syndrome, and Ganyang Huafeng (GYHF ) syndrome; while they were lower in patients with liver deficiency syndromes, including Ganqixu (GQX肝气虚 ) syndrome, Ganxuexu (GXX肝血虚) syndrome, and Ganyinxu (GYX肝阴虚 ) syndrome. Futhermore, when Ganshen Yinxu (GSYX ) syndrome was turned into GYSK and then into GYHF, the plasma NE and E contents in creased in order of precedence; while when GQYJ was turned into Ganyu Pixu (GYPX 肝郁脾虚) syndrome, both NE and E contents decreased. The results suggest that the plasma NE and E contents are reliable objective parameters for the study of pathophysiological ba sis of the liver excess and liver deficiency syndromes, and the liver-kidney and liver-spleen interrelated syndromes.展开更多
Objective:To investigate the differential expression of microRNA(miRNA)in colon between ulcerative colitis(UC)and ulcerative colitis related colorectal cancer(UCRCC).Methods:An UC mouse model was built by dextran sodi...Objective:To investigate the differential expression of microRNA(miRNA)in colon between ulcerative colitis(UC)and ulcerative colitis related colorectal cancer(UCRCC).Methods:An UC mouse model was built by dextran sodium sulfate,and an UCRCC mouse model by dextran sodium sulfate and 1,2-diformylhydrazine.RNAs were extracted from the colon,purified and hybridized with fluorescence-labeled miRNA oligonucleotide gene chip.Real-time fluorescence quantitative PCR was used to verity the expression variation of miRNA.SAM was employed for the data analysis.Results:The up-regulated miRNA in colon cancer included has-miR-194,hasmiR-215,has-miR-93,has-miR-192,has-miR-92a,has-miR-29b,and has-miR-20a(median false discovery rate<5%),while the down-regulated miRNAs were has-miR-1231,has-miR-195,has-miR-143,and has-miR-145(median false discovery rate<5%).Conclusions:Significant differential expression of miRNA was found between the UC mouse and UCRCC mouse,which may be related to the onset,erosion and transfer of colorectal cancer.展开更多
Based on our clinical experience,we formulated Huo Xue Tong Luo Tang(活血通络汤HXTL Decoction),a prescription for treatment of lacunar cerebral infarction.Most of the ingredients are those in the prescriptions of Di D...Based on our clinical experience,we formulated Huo Xue Tong Luo Tang(活血通络汤HXTL Decoction),a prescription for treatment of lacunar cerebral infarction.Most of the ingredients are those in the prescriptions of Di Dang Tang(抵当汤)and Gui Gan Long Mu Tang(桂甘龙牡汤)described in the book Treatise of Febrile Diseases(伤寒论)in accordance with the compatible theory of principal,assistant,adjuvant and guiding drugs for improving blood circulation,removing stasis,dispelling endogenous wind and phlegm,inducing resuscitation,removing obstruction in the channels,and balancing the yin and yang.展开更多
文摘The levels of plasma norepinephrine (NE) and epinephrine (E) were determined by HPLC in 220 patients with various TCM liver syndromes, and in 96 healthy subjects as controls. The plasma NE and E contents were higher in patients with liver excess syndromes, including Ganqi Yujie (GQYJ 肝气郁结 ) syndrome, Ganyang Shangkang (GYSK肮阳上亢) syndrome, Ganhuo Shangyan (GHSY 肝火上炎) syndrome, and Ganyang Huafeng (GYHF ) syndrome; while they were lower in patients with liver deficiency syndromes, including Ganqixu (GQX肝气虚 ) syndrome, Ganxuexu (GXX肝血虚) syndrome, and Ganyinxu (GYX肝阴虚 ) syndrome. Futhermore, when Ganshen Yinxu (GSYX ) syndrome was turned into GYSK and then into GYHF, the plasma NE and E contents in creased in order of precedence; while when GQYJ was turned into Ganyu Pixu (GYPX 肝郁脾虚) syndrome, both NE and E contents decreased. The results suggest that the plasma NE and E contents are reliable objective parameters for the study of pathophysiological ba sis of the liver excess and liver deficiency syndromes, and the liver-kidney and liver-spleen interrelated syndromes.
基金funded by the Science and Technology Planning Project of Guangdong Province,China(NO.2011B031800214)
文摘Objective:To investigate the differential expression of microRNA(miRNA)in colon between ulcerative colitis(UC)and ulcerative colitis related colorectal cancer(UCRCC).Methods:An UC mouse model was built by dextran sodium sulfate,and an UCRCC mouse model by dextran sodium sulfate and 1,2-diformylhydrazine.RNAs were extracted from the colon,purified and hybridized with fluorescence-labeled miRNA oligonucleotide gene chip.Real-time fluorescence quantitative PCR was used to verity the expression variation of miRNA.SAM was employed for the data analysis.Results:The up-regulated miRNA in colon cancer included has-miR-194,hasmiR-215,has-miR-93,has-miR-192,has-miR-92a,has-miR-29b,and has-miR-20a(median false discovery rate<5%),while the down-regulated miRNAs were has-miR-1231,has-miR-195,has-miR-143,and has-miR-145(median false discovery rate<5%).Conclusions:Significant differential expression of miRNA was found between the UC mouse and UCRCC mouse,which may be related to the onset,erosion and transfer of colorectal cancer.
文摘Based on our clinical experience,we formulated Huo Xue Tong Luo Tang(活血通络汤HXTL Decoction),a prescription for treatment of lacunar cerebral infarction.Most of the ingredients are those in the prescriptions of Di Dang Tang(抵当汤)and Gui Gan Long Mu Tang(桂甘龙牡汤)described in the book Treatise of Febrile Diseases(伤寒论)in accordance with the compatible theory of principal,assistant,adjuvant and guiding drugs for improving blood circulation,removing stasis,dispelling endogenous wind and phlegm,inducing resuscitation,removing obstruction in the channels,and balancing the yin and yang.
