A simple and effective procedure for the enantioselective synthesis of (R)- and (S)-moprolol was described. The key step was the asymmetric synthesis of enantiopure (R)- and (S)-guaifenesin, which were synthesized fro...A simple and effective procedure for the enantioselective synthesis of (R)- and (S)-moprolol was described. The key step was the asymmetric synthesis of enantiopure (R)- and (S)-guaifenesin, which were synthesized from enantioenriched (R)-3-chloro-1,2-propanediol and (S)-epichlorohydrin via kinetics of hydrolysis resolution of racemic epichlorohydrin by chiral Salen-CoIII complex. The e.e. values of both the optical compounds were above 98%, and the chemical structures of the target compounds were confirmed by 1H NMR, 13C NMR, IR, and MS.展开更多
A new conformationally restricted cyclic analogue of muramyl dipeptide was designed and manually synthesized by our 揗eshed-Bag Gathered-Bunch?method with a combination of Fmoc, allyl and N-1-(4,4-dimethyl2,6-dioxocyc...A new conformationally restricted cyclic analogue of muramyl dipeptide was designed and manually synthesized by our 揗eshed-Bag Gathered-Bunch?method with a combination of Fmoc, allyl and N-1-(4,4-dimethyl2,6-dioxocyclo-hexylidene)ethyl chemical protection strategy.展开更多
文摘A simple and effective procedure for the enantioselective synthesis of (R)- and (S)-moprolol was described. The key step was the asymmetric synthesis of enantiopure (R)- and (S)-guaifenesin, which were synthesized from enantioenriched (R)-3-chloro-1,2-propanediol and (S)-epichlorohydrin via kinetics of hydrolysis resolution of racemic epichlorohydrin by chiral Salen-CoIII complex. The e.e. values of both the optical compounds were above 98%, and the chemical structures of the target compounds were confirmed by 1H NMR, 13C NMR, IR, and MS.
文摘A new conformationally restricted cyclic analogue of muramyl dipeptide was designed and manually synthesized by our 揗eshed-Bag Gathered-Bunch?method with a combination of Fmoc, allyl and N-1-(4,4-dimethyl2,6-dioxocyclo-hexylidene)ethyl chemical protection strategy.
