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MicroRNA expression profiles and functions in the brain
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作者 Yanting Qi Yu Zhao +4 位作者 Zhuyin Chen Xiaona Chen Marie C. Lin Xiangfu Kong Lihui Lai 《Neural Regeneration Research》 SCIE CAS CSCD 2008年第12期1380-1385,共6页
MicroRNAs are abundant in the brains of vertebrates and some show a brain-specific or brain-enriched expression pattern. Because microRNAs regulate the expression of hundreds of target genes, it is not surprising that... MicroRNAs are abundant in the brains of vertebrates and some show a brain-specific or brain-enriched expression pattern. Because microRNAs regulate the expression of hundreds of target genes, it is not surprising that they have profoundly important functions in brain development and pathological processes. For example, miR-124 plays an important role in inducing and maintaining neuronal identity through targeting at least two anti-neural factors. MicroRNAs have also been implicated in brain disorders, including brain tumors and neurodegenerative diseases. This review aims to present an overview of the expression profiles and functions of microRNAs in the developing brains of vertebrates. 展开更多
关键词 NEUROGENESIS neural cell specification synaptic plasticity posttranscriptional regulator epigenetic control
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