Bowen’s disease with multiple lesions of the penis and scrotum:A case report

Bowen’s disease is a rare squamous cell carcinoma in situ of the skin,the etiology and pathogenesis of which remain unclear.A 57-year-old man presented with the penis and scrotum erythema,with indistinct boundaries with the surrounding tissue.Pathology and histopathology of the biopsy specimen revealed Bowen’s disease.There are many clinical treatments for Bowen’s disease,including surgical excision,liquid nitrogen freezing,electrocautery,laser therapy,topical application of 5-fluorouracil ointment,and photodynamic therapy.Bowen’s disease mostly involves solitary lesions.This case involved multiple lesions,and its scope was extensive;therefore,surgical resection was performed.

Sensory neurons: unveiling the symphony of wound healing

In a recent paper published in Nature,Lu et al.reveal a pivotal role of Nav1.8+nociceptor-released neuropeptide calcitonin generelated peptide(CGRP)in modulating the activities of myeloid cells during skin and muscle injury repair.This study demonstrated the significant impact of sensory neurons on injuryinduced inflammation and wound healing.

Immunomodulatory Nanosystems:Advanced Delivery Tools for Treating Chronic Wounds

The increasingly aging society led to a rise in the prevalence of chronic wounds(CWs),posing a significant burden to public health on a global scale.One of the key features of CWs is the presence of a maladjusted immune microenvironment characterized by persistent and excessive(hyper)inflammation.A variety of immunomodulatory therapies have been proposed to address this condition.Yet,to date,current delivery systems for immunomodulatory therapy remain inadequate and lack efficiency.This highlights the need for new therapeutic delivery systems,such as nanosystems,to manage the pathological inflammatory imbalance and,ultimately,improve the treatment outcomes of CWs.While a plethora of immunomodulatory nanosystems modifying the immune microenvironment of CWs have shown promising therapeutic effects,the literature on the intersection of immunomodulatory nanosystems and CWs remains relatively scarce.Therefore,this review aims to provide a comprehensive overview of the pathogenesis and characteristics of the immune microenvironment in CWs,discuss important advancements in our understanding of CW healing,and delineate the versatility and applicability of immunomodulatory nanosystems-based therapies in the therapeutic management of CWs.In addition,we herein also shed light on the main challenges and future perspectives in this rapidly evolving research field.

Converting fibroblastic fates leads to wound healing without scar

In a recent paper published in Science,Mascharak et al.^(1) demonstrated that inhibiting Engrailed-1 activation in wound fibroblasts promotes scarless wound repair that phenocopies wound repair by regeneration seen in lower taxon groups and rarely in mammals.Many living species of chordates,including vertebrates,respond to injury by regenerating a perfect tissue replica.Mammals and humans on the other hand,with some rare exceptions,replaced true regeneration with scar tissue build-up in wounds.