Stable soft tissue integration around the implant abutment attenuates pathogen penetration,protects underlying bone tissue,prevents peri-implantitis and is essential in maintaining long-term implant stability.The desi...Stable soft tissue integration around the implant abutment attenuates pathogen penetration,protects underlying bone tissue,prevents peri-implantitis and is essential in maintaining long-term implant stability.The desire for“metal free”and“aesthetic restoration”has favored zirconia over titanium abutments,especially for implant restorations in the anterior region and for patients with thin gingival biotype.Soft tissue attachment to the zirconia abutment surface remains a challenge.A comprehensive review of advances in zirconia surface treatment(micro-design)and structural design(macro-design)affecting soft tissue attachment is presented and strategies and research directions are discussed.Soft tissue models for abutment research are described.Guidelines for development of zirconia abutment surfaces that promote soft tissue integration and evidence-based references to inform clinical choice of abutment structure and postoperative maintenance are presented.展开更多
In bone tissue engineering,scaffolds with excellent mechanical and bioactive properties play prominent roles in space maintaining and bone regeneration,attracting increasingly interests in clinical practice.In this st...In bone tissue engineering,scaffolds with excellent mechanical and bioactive properties play prominent roles in space maintaining and bone regeneration,attracting increasingly interests in clinical practice.In this study,strontium-incorporatedβ-tricalcium phosphate(β-TCP),named Sr-TCP,bioceramic triply periodic minimal surface(TPMS)structured scaffolds were successfully fabricated by digital light processing(DLP)-based 3D printing technique,achieving high porosity,enhanced strength,and excellent bioactivity.The Sr-TCP scaffolds were first characterized by element distribution,macrostructure and microstructure,and mechanical properties.Notably,the compressive strength of the scaffolds reached 1.44 MPa with porosity of 80%,bringing a great mechanical breakthrough to porous scaffolds.Furthermore,the Sr-TCP scaffolds also facilitated osteogenic differentiation of mouse osteoblastic cell line(MC3T3-E1)cells in both gene and protein aspects,verified by alkaline phosphatase(ALP)activity and polymerase chain reaction(PCR)assays.Overall,the 3D-printed Sr-TCP bioceramic TPMS structured scaffolds obtained high porosity,boosted strength,and superior bioactivity at the same time,serving as a promising approach for bone regeneration.展开更多
基金supported by the National Nature Science Foundation of China(grants 81720108011,82071169,82100971).
文摘Stable soft tissue integration around the implant abutment attenuates pathogen penetration,protects underlying bone tissue,prevents peri-implantitis and is essential in maintaining long-term implant stability.The desire for“metal free”and“aesthetic restoration”has favored zirconia over titanium abutments,especially for implant restorations in the anterior region and for patients with thin gingival biotype.Soft tissue attachment to the zirconia abutment surface remains a challenge.A comprehensive review of advances in zirconia surface treatment(micro-design)and structural design(macro-design)affecting soft tissue attachment is presented and strategies and research directions are discussed.Soft tissue models for abutment research are described.Guidelines for development of zirconia abutment surfaces that promote soft tissue integration and evidence-based references to inform clinical choice of abutment structure and postoperative maintenance are presented.
基金supported by the National Natural Science Foundation of China(Nos.51972339 and 51802350).
文摘In bone tissue engineering,scaffolds with excellent mechanical and bioactive properties play prominent roles in space maintaining and bone regeneration,attracting increasingly interests in clinical practice.In this study,strontium-incorporatedβ-tricalcium phosphate(β-TCP),named Sr-TCP,bioceramic triply periodic minimal surface(TPMS)structured scaffolds were successfully fabricated by digital light processing(DLP)-based 3D printing technique,achieving high porosity,enhanced strength,and excellent bioactivity.The Sr-TCP scaffolds were first characterized by element distribution,macrostructure and microstructure,and mechanical properties.Notably,the compressive strength of the scaffolds reached 1.44 MPa with porosity of 80%,bringing a great mechanical breakthrough to porous scaffolds.Furthermore,the Sr-TCP scaffolds also facilitated osteogenic differentiation of mouse osteoblastic cell line(MC3T3-E1)cells in both gene and protein aspects,verified by alkaline phosphatase(ALP)activity and polymerase chain reaction(PCR)assays.Overall,the 3D-printed Sr-TCP bioceramic TPMS structured scaffolds obtained high porosity,boosted strength,and superior bioactivity at the same time,serving as a promising approach for bone regeneration.
