期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Robustness Analysis of the IFN-γ Induced JAK-STAT Signaling Pathway 被引量:1
1
作者 资治科 孙之荣 《Journal of Computer Science & Technology》 SCIE EI CSCD 2005年第4期491-495,共5页
Here, the issue of robustness analysis of cell JAK-STAT signal transduction networks is addressed. This is investigated upon a mathematical model of IFN-γ induced JAK-STAT signaling pathway by applying robustness ana... Here, the issue of robustness analysis of cell JAK-STAT signal transduction networks is addressed. This is investigated upon a mathematical model of IFN-γ induced JAK-STAT signaling pathway by applying robustness analysis which is based on a broad range of simultaneous and systematical parameters variation. The effects of the variations of the initial signal proteins' concentrations on the output of this system are also studied. The study demonstrates that the JAK-STAT signaling pathway is robust with respect to its "signal time" and "signal duration", but sensitive with respect to its "signal amplitude". These analysis results can point to experimental designs that can further test how the pathway activity can be perturbed. 展开更多
关键词 JAK-STAT 信号分析 0DEs 数学模型
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部