tract,ranking second among the causes of cancer deaths worldwide,and nearly one million people die of CRC every year,which is a serious threat to human health[1].With the development of the economy and the improvement...tract,ranking second among the causes of cancer deaths worldwide,and nearly one million people die of CRC every year,which is a serious threat to human health[1].With the development of the economy and the improvement of living conditions,people's dietary structure is also quietly changing,and factors such as population aging,obesity,smoking,etc.all increase the risk of CRC[2],CRC morbidity and mortality under the influence of these conditions are showing a rising trend,and gradually younger[3].According to statistics,the incidence of CRC in men is second only to lung cancer and stomach cancer,while in women it is third only to breast cancer and cervical cancer[4–6].At present,there is still no special treatment plan for CRC,and surgery,radiotherapy,chemotherapy,and targeted therapy have long been used as the main treatment modalities.However,patients with malignant tumors often suffer from a variety of underlying diseases,low immunity or even malignant disease,and long-term radiotherapy will kill tumor cells while damaging normal cells,which is therefore difficult for patients to tolerate,and the quality of life of end-stage CRC patients is even more difficult.Therefore,it is often difficult for patients to tolerate it,and the quality of life of end-stage CRC patients is even more difficult to be guaranteed[7].展开更多
Migraine is a common chronic neurological disorder with a global disease burden second only to stroke among neurological disorders[1,2].Although some authors have suggested that prophylactic drugs should be recommende...Migraine is a common chronic neurological disorder with a global disease burden second only to stroke among neurological disorders[1,2].Although some authors have suggested that prophylactic drugs should be recommended for migraine patients who have at least four headache days per month,only 13%of patients reported current use of preventive drugs[3].Ineffectiveness of and/or contraindications to migraine medication affect 10%-15%of people with migraine[3].Hence,a need exists to investigate non-drug interventions.Acupuncture has emerged as a prophylactic treatment for migraine because of its potential efficacy[3,4].展开更多
Severe acute respiratory syndrome coronavirus 2(S ARS-CoV-2)has caused millions of deaths,and the development of COVID-19 v accines has achieved breakthroughs at an unprecedented speed.Since Aug 11,2020,at least 20 in...Severe acute respiratory syndrome coronavirus 2(S ARS-CoV-2)has caused millions of deaths,and the development of COVID-19 v accines has achieved breakthroughs at an unprecedented speed.Since Aug 11,2020,at least 20 intramuscular COVID-19 vaccines have been approved for use,including adenovirus type-5 vector-based COVID-19 vaccine(Ad5-nCoV)[1-4].Previous work in animal models has shown that a singlemucosal vaccination with Ad5-nCoV protects from wild-type SARS-CoV-2 replication in the upper respiratory tract.Interim analysis of data from a multicountry trial showed that Ad5-nCoV has an acceptable efficacy for preventing symptomatic COVID-19 cases[1-4].展开更多
文摘tract,ranking second among the causes of cancer deaths worldwide,and nearly one million people die of CRC every year,which is a serious threat to human health[1].With the development of the economy and the improvement of living conditions,people's dietary structure is also quietly changing,and factors such as population aging,obesity,smoking,etc.all increase the risk of CRC[2],CRC morbidity and mortality under the influence of these conditions are showing a rising trend,and gradually younger[3].According to statistics,the incidence of CRC in men is second only to lung cancer and stomach cancer,while in women it is third only to breast cancer and cervical cancer[4–6].At present,there is still no special treatment plan for CRC,and surgery,radiotherapy,chemotherapy,and targeted therapy have long been used as the main treatment modalities.However,patients with malignant tumors often suffer from a variety of underlying diseases,low immunity or even malignant disease,and long-term radiotherapy will kill tumor cells while damaging normal cells,which is therefore difficult for patients to tolerate,and the quality of life of end-stage CRC patients is even more difficult.Therefore,it is often difficult for patients to tolerate it,and the quality of life of end-stage CRC patients is even more difficult to be guaranteed[7].
文摘Migraine is a common chronic neurological disorder with a global disease burden second only to stroke among neurological disorders[1,2].Although some authors have suggested that prophylactic drugs should be recommended for migraine patients who have at least four headache days per month,only 13%of patients reported current use of preventive drugs[3].Ineffectiveness of and/or contraindications to migraine medication affect 10%-15%of people with migraine[3].Hence,a need exists to investigate non-drug interventions.Acupuncture has emerged as a prophylactic treatment for migraine because of its potential efficacy[3,4].
文摘Severe acute respiratory syndrome coronavirus 2(S ARS-CoV-2)has caused millions of deaths,and the development of COVID-19 v accines has achieved breakthroughs at an unprecedented speed.Since Aug 11,2020,at least 20 intramuscular COVID-19 vaccines have been approved for use,including adenovirus type-5 vector-based COVID-19 vaccine(Ad5-nCoV)[1-4].Previous work in animal models has shown that a singlemucosal vaccination with Ad5-nCoV protects from wild-type SARS-CoV-2 replication in the upper respiratory tract.Interim analysis of data from a multicountry trial showed that Ad5-nCoV has an acceptable efficacy for preventing symptomatic COVID-19 cases[1-4].
