Parkinson’s disease (P D) is a com plex neu rodegenerative disorder for which ra re and common genetic variants contribute to disease risk,onset,and progression.The genetic contribution to PD can be classified mainly...Parkinson’s disease (P D) is a com plex neu rodegenerative disorder for which ra re and common genetic variants contribute to disease risk,onset,and progression.The genetic contribution to PD can be classified mainly in,first,rare DNA variants that are highly penetrant and therefore causal,which are typically associated with monogenic PD;and second,more common risk polymorphic variants,which individually exert a small increase in the risk of the disease,which are usually identified in the most prevalent and apparently sporadic PD (Blauwendraat et al.,2020).展开更多
The basal ganglia （BG） assemble a series of deep gray matter structures forming recurrent loops that include the cortex and thalamus, and that participate in the regulation of a plethora of brain functions, includin...The basal ganglia （BG） assemble a series of deep gray matter structures forming recurrent loops that include the cortex and thalamus, and that participate in the regulation of a plethora of brain functions, including elicitation and learning of reward-and aversive stimuli-associated behaviors, motor activity control and sensorimotor gating （Brom- berg-Martin et al., 2010）.展开更多
基金supported by the intra mural funds of the National Institute in drug abuse (ZIA DA000493)(to SF)projects PID2019-109240RB-I00(to LP) and PID2020-118511RB-I00 (to FC) were founded by MCIN/AEI/10.13039/501100011033,"ERDF A way of making Europe"。
文摘Parkinson’s disease (P D) is a com plex neu rodegenerative disorder for which ra re and common genetic variants contribute to disease risk,onset,and progression.The genetic contribution to PD can be classified mainly in,first,rare DNA variants that are highly penetrant and therefore causal,which are typically associated with monogenic PD;and second,more common risk polymorphic variants,which individually exert a small increase in the risk of the disease,which are usually identified in the most prevalent and apparently sporadic PD (Blauwendraat et al.,2020).
基金supported by MINECO/ISCⅢ(SAF2014-55700-P and PIE14/00034)IWT(SBO-140028)+2 种基金Fundacióla Maratóde TV3(Grant 20152031)to FCFC and VFD belong to the“Neuropharmacology and Pain”accredited research group(Generalitat de Catalunya,2014 SGR 1251)the intramural funds of the National Institute on Drug Abuse to SF
文摘The basal ganglia （BG） assemble a series of deep gray matter structures forming recurrent loops that include the cortex and thalamus, and that participate in the regulation of a plethora of brain functions, including elicitation and learning of reward-and aversive stimuli-associated behaviors, motor activity control and sensorimotor gating （Brom- berg-Martin et al., 2010）.
