Scientific Value Weights more than Being Open or Toll Access:An analysis of the OA advantage in Nature and Science

Purpose:We attempt to find out whether OA or TA really affects the dissemination of scientific discoveries.Design/methodology/approach:We design the indicators,hot-degree,and R-index to indicate a topic OA or TA advantages.First,according to the OA classification of the Web of Science(WoS),we collect data from the WoS by downloading OA and TA articles,letters,and reviews published in Nature and Science during 2010–2019.These papers are divided into three broad disciplines,namely biomedicine,physics,and others.Then,taking a discipline in a journal and using the classical Latent Dirichlet Allocation(LDA)to cluster 100 topics of OA and TA papers respectively,we apply the Pearson correlation coefficient to match the topics of OA and TA,and calculate the hot-degree and R-index of every OA-TA topic pair.Finally,characteristics of the discipline can be presented.In qualitative comparison,we choose some high-quality papers which belong to Nature remarkable papers or Science breakthroughs,and analyze the relations between OA/TA and citation numbers.Findings:The result shows that OA hot-degree in biomedicine is significantly greater than that of TA,but significantly less than that of TA in physics.Based on the R-index,it is found that OA advantages exist in biomedicine and TA advantages do in physics.Therefore,the dissemination of average scientific discoveries in all fields is not necessarily affected by OA or TA.However,OA promotes the spread of important scientific discoveries in high-quality papers.Research limitations:We lost some citations by ignoring other open sources such as arXiv and bioArxiv.Another limitation came from that Nature employs some strong measures for access-promoting subscription-based articles,on which the boundary between OA and TA became fuzzy.Practical implications:It is useful to select hot topics in a set of publications by the hotdegree index.The finding comprehensively reflects the differences of OA and TA in different disciplines,which is a useful reference when researchers choose the publishing way as OA or TA.Originality/value:We propose a new method,including two indicators,to explore and measure OA or TA advantages.

CHDbase:A Comprehensive Knowledgebase for Congenital Heart Disease-related Genes and Clinical Manifestations

Congenital heart disease(CHD)is one of the most common causes of major birth defects,with a prevalence of 1%.Although an increasing number of studies have reported the etiology of CHD,the findings scattered throughout the literature are difficult to retrieve and utilize in research and clinical practice.We therefore developed CHDbase,an evidence-based knowledgebase of CHD-related genes and clinical manifestations manually curated from 1114 publications,linking 1124 susceptibility genes and 3591 variations to more than 300 CHD types and related syndromes.Metadata such as the information of each publication and the selected population and samples,the strategy of studies,and the major findings of studies were integrated with each item of the research record.We also integrated functional annotations through parsing50 databases/tools to facilitate the interpretation of these genes and variations in disease pathogenicity.We further prioritized the significance of these CHD-related genes with a gene interaction network approach and extracted a core CHD sub-network with 163 genes.The clear genetic landscape of CHD enables the phenotype classification based on the shared genetic origin.Overall,CHDbase provides a comprehensive and freely available resource to study CHD susceptibilities,supporting a wide range of users in the scientific and medical communities.CHDbase is accessible at http://chddb.fwgenetics.org.