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Microstructural morphology and visual acuity outcome in eyes with epiretinal membrane before,during,and after membrane peeling in intraoperative optical coherence tomography assisted macular surgery 被引量:2
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作者 Melanie Weschta Moritz Pettenkofer +3 位作者 Julian EKlaas Nikolaus Feucht Chris PLohmann Mathias Maier 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第5期748-754,共7页
AIM:To measure the difference of intraoperative central macular thickness(CMT)before,during,and after membrane peeling and investigate the influence of intraoperative macular stretching on postoperative best corrected... AIM:To measure the difference of intraoperative central macular thickness(CMT)before,during,and after membrane peeling and investigate the influence of intraoperative macular stretching on postoperative best corrected visual acuity(BCVA)outcome and postoperative CMT development.METHODS:A total of 59 eyes of 59 patients who underwent vitreoretinal surgery for epiretinal membrane was analyzed.Videos with intraoperative optical coherence tomography(OCT)were recorded.Difference of intraoperative CMT before,during,and after peeling was measured.Pre-and postoperatively obtained BCVA and spectral-domain OCT images were analyzed.RESULTS:Mean age of the patients was 70±8.13y(range 46-86y).Mean baseline BCVA was 0.49±0.27 log MAR(range 0.1-1.3).Three and six months postoperatively the mean BCVA was 0.36±0.25(P=0.01 vs baseline)and 0.38±0.35(P=0.08 vs baseline)log MAR respectively.Mean stretch of the macula during surgery was 29%from baseline(range 2%-159%).Intraoperative findings of macular stretching did not correlate with visual acuity outcome within 6mo after surgery(r=-0.06,P=0.72).However,extent of macular stretching during surgery significantly correlated with less reduction of CMT at the fovea centralis(r=-0.43,P<0.01)and 1 mm nasal and temporal from the fovea(r=-0.37,P=0.02 and r=-0.50,P<0.01 respectively)3mo postoperatively.CONCLUSION:The extent of retinal stretching during membrane peeling may predict the development of postoperative central retinal thickness,though there is no correlation with visual acuity development within the first 6mo postoperatively. 展开更多
关键词 retinal imaging treatment surgery intraoperative optical coherence tomography epiretinal membrane
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受呼吸运动影响的器官和血管结构螺旋式CT数据的三维重建 被引量:1
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作者 J.Gmeinwieser A.P.Wunderlich +2 位作者 P.Gerhardt M.Strotzer 刘建斌 《放射学实践》 北大核心 1993年第2期59-65,共7页
将新的CT技术螺旋式扫描与现代图像处理方法相结合,第一次得到了胸腹呼吸移动器官和血管结构三维重建的满意图像。这在MIPRON控制台(KONTRON,Eching bei Munchen)上已经实现。其临床应用范围主要是肝脏、胰腺和中上纵隔的肿瘤病变。
关键词 CT 螺旋式 呼吸器官 血管结构
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Different profiles of cytokine expression during mild and severe acute pancreatitis 被引量:50
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作者 Zilvinas Dambrauskas Nathalia Giese +5 位作者 Antanas Gulbinas Thomas Giese Pascal O Berberat Juozas Pundzius Giedrius Barauskas Helmut Friess 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第15期1845-1853,共9页
AIM:To study secretion patterns of proand anti-in-flammatory cytokines, and activation of various cellular subsets of leukocytes in peripheral blood.METHODS: We have conducted a prospective obser-vational study. One h... AIM:To study secretion patterns of proand anti-in-flammatory cytokines, and activation of various cellular subsets of leukocytes in peripheral blood.METHODS: We have conducted a prospective obser-vational study. One hundred and eight patients with a diagnosis of acute pancreatitis and onset of the disease within last 72 h were included in this study. The mRNA expression of 25 different types of cytokines in white blood cells was determined by quantitative real time polymerase chain reaction. Levels of 8 different cytokines in blood serum were measured by enzymelinked immunosorbent assay. Clinical data and cytokine expression results were subjected to statistical analysis.RESULTS: Severe and necrotizing acute pancreatitis (AP) is characterized by the significant depletion of circulating lymphocytes. Severe acute pancreatitis is as-sociated with a typical systemic inflammatory response syndrome and over-expression of pro-inflammatory cy-tokines [interleukin (IL)-6, IL-8, macrophage migration inhibitory factor (MIF)]. Serum IL-6 and MIF concentra-tions are the best discriminators of severe and necrotiz-ing AP as well as possible fatal outcome during the early course of the disease. CONCLUSION: Deregulation of cellular immune sys-tem is a key event leading to severe and necrotizing AP. IL-6 and MIF could be used as early predictors of complications. 展开更多
关键词 Acute pancreatitis CYTOKINES Prognostic factors
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脊柱旁肌水-脂肪MRI测量与等长肌力测量的关系 被引量:15
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作者 S.Schlaeger S.Inhuber +5 位作者 A.Rohrmeier M.Dieckmeyer F.Freitag E.Klupp 宋燕燕(译) 赵世华(校) 《国际医学放射学杂志》 北大核心 2019年第2期250-250,共1页
目的基于化学位移编码的水-脂肪MRI衍生的脊髓旁肌肉质子密度脂肪分数(PDFF)已成为肌肉减少、腰痛、损伤和神经肌肉疾病病人的替代标志物。本研究旨在探讨椎旁肌PDFF及横断面面积(CSA)对等长肌力的预测能力。
关键词 MRI 等长肌力
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常规胸腹部多层CT矢状重组影像在检测骨质疏松骨折和脊椎异常诊断中的价值 被引量:6
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作者 D. Müller J.S. Bauer +4 位作者 M. Zeile E.J. Rummeny T.M. Link 白荣杰(译) 唐光健(校) 《国际医学放射学杂志》 2008年第5期421-422,共2页
本研究的目的是评价骨质疏松椎骨骨折和其他椎骨损伤在常规多层CT(MDCT)胸腹部扫描获得的矢状重组影像上的表现,以及在检出这些病变时矢状重组影像与横断位影像的差异,并研究这些病变在放射科报告中漏报的频度。112例绝经后妇女接... 本研究的目的是评价骨质疏松椎骨骨折和其他椎骨损伤在常规多层CT(MDCT)胸腹部扫描获得的矢状重组影像上的表现,以及在检出这些病变时矢状重组影像与横断位影像的差异,并研究这些病变在放射科报告中漏报的频度。112例绝经后妇女接受标准参数的常规腹部或胸腹部MDCT检查。横断位和矢状重组影像由2位放射科医师分别进行分析比较,并达成一致意见.以评价这些异常被检出的频度。此外还评价了放射科的报告,明确有多少异常得以诊断。112例绝经妇女中,101例显示脊椎异常。 展开更多
关键词 常规多层CT 脊柱 骨质疏松 椎骨骨折 矢状 重组
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视频照像机和激光照像机系统
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作者 Paul Gerhardt Dieter Boltz +1 位作者 万忠诚 肖秋华 《放射学实践》 北大核心 1992年第1期1-7,共7页
视频照像机通常也被称为多幅照像机或CRT照像机(阴极射线管照像机)。视频照像机的曝光原理同所有照像机一样,即视频信号通过照像机内的阴极射线管转换成视频图像传送给监视器,然后通过反射镜和物镜系统而获得图像。反射镜和物镜系统使... 视频照像机通常也被称为多幅照像机或CRT照像机(阴极射线管照像机)。视频照像机的曝光原理同所有照像机一样,即视频信号通过照像机内的阴极射线管转换成视频图像传送给监视器,然后通过反射镜和物镜系统而获得图像。反射镜和物镜系统使图像质量得到保证。视频照像机依赖于视频信号所提供的扫描行数,而反射镜、物镜系统的质量却依赖于荧光屏上发光物质的涂层颗粒(磷)。 展开更多
关键词 视频照像机 激光照像机
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Pancreatic cancer–Molecular alterations 被引量:1
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作者 Günter Schneider Dieter Saur Roland M. Schmid1 《The Chinese-German Journal of Clinical Oncology》 CAS 2007年第2期102-106,共5页
Pancreatic ductal adenocarcinoma is a dismal disease with a median survival below 6 months and a 5 year survival rate below 1%. High mortality is due to early lymphatic and hematogenic dissemination. Effective therapi... Pancreatic ductal adenocarcinoma is a dismal disease with a median survival below 6 months and a 5 year survival rate below 1%. High mortality is due to early lymphatic and hematogenic dissemination. Effective therapies for local advanced or metastatic tumors are missing and curative resected patients relapse in over 80% of the cases. Together this findings reflects the aggressive biology of the disease. Here we describe molecular mechanisms leading to unrestrained proliferation, insensitivity to growth inhibitory signals, evasion of apoptosis, limitless replicative potential, tissue invasion, metastasis and sustained angiogenesis. 展开更多
关键词 pancreatic ductal adenocarcinoma INK4A K-RAS SMAD4 TP53
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继发性甲状旁腺功能亢进时锁骨外段下缘的韧带下骨质吸收
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作者 C.Kutschker K.Brandstetter 蔡培华 《放射学实践》 北大核心 1992年第4期177-178,共2页
除了罕见的骨肥厚和软组织钙化外,皮质内和骨膜下骨质吸收和骨质溶解,是甲状旁腺功能亢进的X线征象。X线片显示的不同表现有利于鉴别诊断。
关键词 继发性甲状旁腺功能亢进 锁骨外段下缘 韧带下 骨质吸收 X线
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纵隔肿瘤术后超声偶然发现无临床症状的下腔静脉血栓
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作者 K.Brandstetter B.Allgayer +1 位作者 K.Mühlbauer 乐桂蓉 《放射学实践》 北大核心 1993年第1期18-20,共3页
当疑有下腔静脉血栓形成时,超声、CT和磁共振是很好的检查方法。下腔静脉造影是显示侧支静脉的最重要手段。
关键词 纵隔肿瘤 下腔静脉 血栓 超声波
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上消化道的防癌措施
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作者 C.Lersch M.Classen 王天才 《德国医学》 CAS 1999年第3期141-143,共3页
所谓癌预防即排除有关的危险因素,如酒精、尼古丁、食物内的致癌物质等或摄入保护性因素,如维生素E、β-葫萝卜素或阿斯匹林。另外癌肿的预防还表示尽早识别上消化道的危险状况和病变,并通过对其进行治疗以阻止侵入性肿瘤的发生。这主... 所谓癌预防即排除有关的危险因素,如酒精、尼古丁、食物内的致癌物质等或摄入保护性因素,如维生素E、β-葫萝卜素或阿斯匹林。另外癌肿的预防还表示尽早识别上消化道的危险状况和病变,并通过对其进行治疗以阻止侵入性肿瘤的发生。这主要是指食管癌和胃癌,而不是指小肠癌(十二指肠除外)、胰腺癌和胆管癌。这类癌肿因临床症状少,多发现过晚。 展开更多
关键词 上消化道肿瘤 预防 癌前病变
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磁共振在临床常规中的应用心脏和大血管的检查
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作者 R.Bauer U.Busch +3 位作者 E.van de Flierdt G.Schrter H. Stern 王天才 《放射学实践》 北大核心 1992年第1期41-46,共6页
随着新诊断方法的发展,有可能减少损伤性检查所致的不可避免的并发症的发生率。这在磁共振检查方面尤为明显,对心脏疾病的诊断具有重要的价值。
关键词 心脏 血管 NMR
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气体作为造影剂在回旋肌鞘超声检查的应用(气体超声)——超声诊断的新观点
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作者 W.Hawe 乐桂蓉 《放射学实践》 北大核心 1992年第3期116-119,共4页
近年来超声对于运动创伤学的诊断价值越来越重要。尤其是对膝、肩关节以及肌肉、肌腱的诊断具有重要意义。超声脉冲在组织内被吸收、阻断、折射、散射和反射。肌腱组织内的反射有可能发生声阻抗的改变,肌腱组织的连续性断离或退行性变... 近年来超声对于运动创伤学的诊断价值越来越重要。尤其是对膝、肩关节以及肌肉、肌腱的诊断具有重要意义。超声脉冲在组织内被吸收、阻断、折射、散射和反射。肌腱组织内的反射有可能发生声阻抗的改变,肌腱组织的连续性断离或退行性变时可出现上述情况,并在超声图像上可显示出类似的回声图像。为了能有的放矢的采取治疗措施。 展开更多
关键词 气体 超声检查 造影剂
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距骨剥脱性骨软骨病和骨样骨瘤的罕见联合发病
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作者 H.Daschner W.Golder 蔡培华 《放射学实践》 北大核心 1992年第2期71-73,共3页
剥脱性骨软骨病属于原发的或创伤后引起的坏死剥脱,发生在有沉重负荷关节的软骨下.剥脱性骨软骨病发病年龄多在20~30岁,除膝、髋关节外,较多发生于踝关节,好发部位为距骨滑车内缘,病变有时呈双侧对称. 骨样骨瘤系指伴有中心病灶和环灶... 剥脱性骨软骨病属于原发的或创伤后引起的坏死剥脱,发生在有沉重负荷关节的软骨下.剥脱性骨软骨病发病年龄多在20~30岁,除膝、髋关节外,较多发生于踝关节,好发部位为距骨滑车内缘,病变有时呈双侧对称. 骨样骨瘤系指伴有中心病灶和环灶硬化的典型疼痛性良性新生物,其发病年龄同样主要在20~30岁,以股骨和胫骨最为多见,少见于指(趾)骨、掌骨和跖骨。 展开更多
关键词 骨软骨病 骨样骨瘤 诊断
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食管癌的CT和MRT放射学诊断的策略
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作者 K.Brandstetter St.Feuerbach +2 位作者 J.R.Siewert P.Gerhardt 徐霓霓 《放射学实践》 北大核心 1993年第1期32-37,共6页
传统X线技术和内窥镜检查在食管疾患的诊断中占主导地位。因为只有这两种方法能判断粘膜表面以及功能障碍。借助CT和MRT能确定食管疝、憩室和食管痉挛时的病理性扩张,并能较内窥镜和传统食管造影提供更多的信息。
关键词 食管肿瘤 X线诊断
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细菌性脑膜脑炎个案报道及鉴别诊断 被引量:2
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作者 W.Huber M.Seige +4 位作者 H.Stimmer K.Kamereck U.Schweigart M.Classen 彭小楚 《德国医学》 1999年第3期151-153,共3页
一例51岁的女性患者4天来因每日反复发作呕吐、与体位及运动有关的眩晕、轻微头痛及至38℃的低热被疑及胃肠道感染收院。除因左侧乳腺癌曾行胸部手术并予1990年及1992年作过假体置入外,其它病史不明显。3个月前进行的有关妇科对照检查... 一例51岁的女性患者4天来因每日反复发作呕吐、与体位及运动有关的眩晕、轻微头痛及至38℃的低热被疑及胃肠道感染收院。除因左侧乳腺癌曾行胸部手术并予1990年及1992年作过假体置入外,其它病史不明显。3个月前进行的有关妇科对照检查亦无明显异常,患者否认国外旅居及不洁饮食史。 展开更多
关键词 脑膜脑炎 细菌性 诊断 鉴别诊断
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腹腔镜胆囊切除术的失误和危险
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作者 J.R.Siewert H.Feussner +2 位作者 M.A.Scherer I.B.Brune 张应天 《德国医学》 1994年第3期170-171,共2页
腹腔镜胆囊切除术(LC),热潮一度来势迅猛,使人没有时间对其详细评估而列为常规。资料虽多来自积极应用 LC 有经验的医院,然迄今报道中有'报喜不报忧'的情况。资料和方法收集比较国外文献1986~1992年 LC 共25 644例、1988~199... 腹腔镜胆囊切除术(LC),热潮一度来势迅猛,使人没有时间对其详细评估而列为常规。资料虽多来自积极应用 LC 有经验的医院,然迄今报道中有'报喜不报忧'的情况。资料和方法收集比较国外文献1986~1992年 LC 共25 644例、1988~1992年剖腹胆囊切除术(OC)18 017例的并发症发生率和死亡率、德国(1990~1992年) 展开更多
关键词 腹腔镜检 胆囊切除 失误 危险
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肺炎性假瘤病例报告
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作者 M.Strotzer K.Lehner +1 位作者 K.Brandstetter 蒋培华 《放射学实践》 北大核心 1993年第1期21-22,共2页
鉴别诊断肺球形病灶时,必须将炎性假瘤考虑在内,因其可能被误诊为恶性肿瘤。
关键词 肺炎 肺炎性假瘤 诊断
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Kallikrein-related peptidases 6 and 10 are elevated in cerebrospinal fluid of patients with Alzheimer’s disease and associated with CSF-TAU and FDG-PET 被引量:3
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作者 Oliver Goldhardt Inanna Warnhoff +7 位作者 Igor Yakushev Ilijana Begcevic Hans Förstl Viktor Magdolen Antoninus Soosaipillai Eleftherios Diamandis Panagiotis Alexopoulos Timo Grimmer 《Translational Neurodegeneration》 SCIE CAS 2019年第1期304-316,共13页
Background:Alterations in the expression of human kallikrein-related peptidases(KLKs)have been described in patients with Alzheimer’s disease(AD).We elucidated the suitability of KLK6,KLK8 and KLK10 to distinguish AD... Background:Alterations in the expression of human kallikrein-related peptidases(KLKs)have been described in patients with Alzheimer’s disease(AD).We elucidated the suitability of KLK6,KLK8 and KLK10 to distinguish AD from NC and explored associations with established AD biomarkers.Methods:KLK levels in cerebrospinal fluid(CSF),as determined by ELISA,were compared between 32 AD patients stratified to A/T/(N)system with evidence for amyloid pathology and of 23 normal controls with normal AD biomarkers.Associations between KLK levels and clinical severity,CSF and positron emission tomography(PET)based AD biomarkers were tested for.Results:Levels of KLK6 and KLK10 were significantly increased in AD.KLK6 differed significantly between AD A+/T+/N+and AD A+/T−/N+or NC with an AUC of 0.922.CSF pTau and tTau levels were significantly associated with KLK6 in AD.Conclusions:KLK6 deserves further investigations as a potential biomarker of Tau pathology in AD. 展开更多
关键词 Alzheimer’s disease(AD) Kallikrein-like peptidase(KLK) KLK6 KLK8 KLK10 Cerebral amyloid load Cerebrospinal fluid(CSF) Amyloid 1-42 Aβ1-42 Aβ42 Tau protein Total tau tTau Phospho tau pTau Positron emission tomography(PET)
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Association between Taenia solium infection and HIV/AIDS in northern Tanzania: a matched cross sectional-study 被引量:1
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作者 Veronika Schmidt Christian Kositz +7 位作者 Karl-Heinz Herbinger Hélène Carabin Bernard Ngowi Ezra Naman Patricia P.Wilkins John Noh William Matuja Andrea Sylvia Winkler 《Infectious Diseases of Poverty》 SCIE 2016年第1期1022-1036,共15页
Background:The frequency of Taenia solium,a zoonotic helminth,is increasing in many countries of sub-Saharan Africa,where the prevalence of the human immunodeficiency virus(HIV)is also high.However,little is known abo... Background:The frequency of Taenia solium,a zoonotic helminth,is increasing in many countries of sub-Saharan Africa,where the prevalence of the human immunodeficiency virus(HIV)is also high.However,little is known about how these two infections interact.The aim of this study was to compare the proportion of HIV positive(+)and negative(−)individuals who are infected with Taenia solium(TSOL)and who present with clinical and neurological manifestations of cysticercosis(CC).Methods:In northern Tanzania,170 HIV+individuals and 170 HIV–controls matched for gender,age and village of origin were recruited.HIV staging and serological tests for TSOL antibodies(Ab)and antigen(Ag)were performed.Neurocysticercosis(NCC)was determined by computed tomography(CT)using standard diagnostic criteria.Neurological manifestations were confirmed by a standard neurological examination.In addition,demographic,clinical and neuroimaging data were collected.Further,CD4^(+)cell counts as well as information on highly active antiretroviral treatment(HAART)were noted.Results:No significant differences between HIV+and HIV–individuals regarding the sero-prevalence of taeniosis-Ab(0.6%vs 1.2%),CC-Ab(2.4%vs 2.4%)and CC-Ag(0.6%vs 0.0%)were detected.A total of six NCC cases(3 HIV+and 3 HIV–)were detected in the group of matched participants.Two individuals(1 HIV+and 1 HIV–)presented with headaches as the main symptom for NCC,and four with asymptomatic NCC.Among the HIV+group,TSOL was not associated with CD4+cell counts,HAART duration or HIV stage.Conclusions:This study found lower prevalence of taeniosis,CC and NCC than had been reported in the region to date.This low level of infection may have resulted in an inability to find cross-sectional associations between HIV status and TSOL infection or NCC.Larger sample sizes will be required in future studies conducted in that area to conclude if HIV influences the way NCC manifests itself. 展开更多
关键词 Taenia solium Taeniosis CYSTICERCOSIS NEUROCYSTICERCOSIS HIV AIDS CO-INFECTION HELMINTH TAPEWORM Prevalence
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Artificial Intelligence in Neuro-oncology:Friend or Foe of Neurosurgeons?
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作者 Zhenyu GONG Maximilian SCHWENDNER Tao XU 《Clinical Cancer Bulletin》 2022年第1期39-46,共8页
As one of the tumors with substantial treatment difficulties,brain tumors have a high mortality rate and high treatment costs.Furthermore,surgical rection of deep-seated tumors or tumors involving eloquent areas is st... As one of the tumors with substantial treatment difficulties,brain tumors have a high mortality rate and high treatment costs.Furthermore,surgical rection of deep-seated tumors or tumors involving eloquent areas is still a challenge for neurosurgeons.Therefore,accurate and early tumor diagnosis,selection of treatment options,and prediction of prognosis are important to improve patients’outcomes.Recently,with the rapid development of computational technology,the frequency of its application in clinical work has increased enormously and the acquisition of medical data has become more convenient and efficient.Furthermore,with the advancement of artificial intelligence(AI)—particularly,machine and deep learning—the applications of AI in medicine and especially neuro-oncology have enhanced diagnosis,treatment,and prognosis prediction of brain tumors topreviously unachievable levels.This article presents an overview of the applications of AI in neuro-oncology for diagnosis,prognosis,surgical treatment,and education.Furthermore,the advantages,perspectives,and challenges of AI for clinical applications in neuro-oncology are discussed. 展开更多
关键词 artificial intelligence deep learning machine learning NEURO-ONCOLOGY
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