The discovery of chirped pulse amplification has led to great improvements in laser technology,enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few micrometer...The discovery of chirped pulse amplification has led to great improvements in laser technology,enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few micrometers.Protons with energies of tens of MeV can be accelerated using,for instance,target normal sheath acceleration and focused on secondary targets.Under such conditions,nuclear reactions can occur,with the production of radioisotopes suitable for medical application.The use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on accelerators.In this paper,we study the production of^(67)Cu,^(63)Zn,^(18)F,and^(11)C,which are currently used in positron emission tomography and other applications.At the same time,we study the reactions^(10)B(p,α)^(7)Be and^(70)Zn(p,4n)^(67)Ga to put further constraints on the proton distributions at different angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy production.The experiment was performed at the 1 PW laser facility at VegaⅢin Salamanca,Spain.Angular distributions of radioisotopes in the forward(with respect to the laser direction)and backward directions were measured using a high purity germanium detector.Our results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera[Nucl.Instrum.Methods Phys.Res.,Sect.A 637,164–170(2011)].展开更多
In this paper we provide evidence that the Cassie-to-Wenzel transition, despite its detrimental effects on the wetting properties of superhydrophobic surfaces, can be exploited as an effective micro-fabrication strate...In this paper we provide evidence that the Cassie-to-Wenzel transition, despite its detrimental effects on the wetting properties of superhydrophobic surfaces, can be exploited as an effective micro-fabrication strategy to obtain highly ordered arrays of biological objects. To this purpose we fabricated a patterned surface wetted in the Cassie state, where we deposited a droplet containing genomic DNA. We observed that, when the droplet wets the surface in the Cassie state, an array of DNA filaments pinned on the top edges between pillars is formed. Conversely, when the Cassie-to-Wenzel transition occurs, DNA can be pinned at different height between pillars. These results open the way to the realization of tridimensional arrays of biological objects.展开更多
Active galactic nuclei(AGNs) can be divided into two major classes, namely radio-loud and radio-quiet AGNs. A small subset of the radio-loud AGNs is called blazars, which are believed to be unified with Fanaroff-Riley...Active galactic nuclei(AGNs) can be divided into two major classes, namely radio-loud and radio-quiet AGNs. A small subset of the radio-loud AGNs is called blazars, which are believed to be unified with Fanaroff-Riley type Ⅰ/Ⅱ(FRI/Ⅱ) radio galaxies. Following our previous work(Fan et al.), we present a sample of 2400 sources with measured radio flux densities of the core and extended components. The sample contains 250 BL Lacs, 520 quasars, 175 Seyferts, 1178 galaxies, 153 FRI or FRⅡ galaxies and 104 unidentified sources. We then calculate the radio core-dominance parameters and spectral indices, and study their relationship. Our analysis shows that the core-dominance parameters and spectral indices are quite different for different types of sources. We also confirm that the correlation between core-dominance parameter and spectral index exists for a large sample presented in this work.展开更多
The time-of-flight enhanced diagnostics(TOFED)neutron spectrometer has been installed in TOFED house,which is a newly-built neutron diagnostic lab outside the EAST experimental hall.The line of sight(LOS)of TOFED is d...The time-of-flight enhanced diagnostics(TOFED)neutron spectrometer has been installed in TOFED house,which is a newly-built neutron diagnostic lab outside the EAST experimental hall.The line of sight(LOS)of TOFED is defined by the collimator going through the 150 cm biological shielding wall,which can reduce background neutrons very effectively for the neutron spectral measurements.The Monte Carlo code MCNP5 is used in the simulations to characterize collimation effects and the radiation safety of the new house.The collimator makes neutron flux almost fully perpendicular to S 1 detectors.In addition,the proportion of scattered neutrons in the LOS of the TOFED is obtained for the measured spectral data interpretation.The simulation results show that the TOFED house satisfies the requirement for the TOFED operations at EAST and gives a safe environment for personnel access during the EAST operation.展开更多
The excitation functions of dissipative products have been measured in the reaction 27Al+27Al at incident energies from 114 to 127MeV in steps of 200keV. Detection angles vary continuously from 10.4° to 57.4°...The excitation functions of dissipative products have been measured in the reaction 27Al+27Al at incident energies from 114 to 127MeV in steps of 200keV. Detection angles vary continuously from 10.4° to 57.4° in laboratory system. An angular coherent width more than 40° in center of mass is obtained. The results from the analysis of excitation functions with nonself-averaging are characterized by a quasi-periodic long-range energy structure embedded in the disorder Ericson fluctuation.展开更多
Active galactic nuclei(AGNs) can be divided into two major classes,namely radio-loud and radio-quiet AGNs.A small subset of the radio-loud AGNs is called blazars,which are believed to be unified with Fanaroff-Riley ty...Active galactic nuclei(AGNs) can be divided into two major classes,namely radio-loud and radio-quiet AGNs.A small subset of the radio-loud AGNs is called blazars,which are believed to be unified with Fanaroff-Riley type Ⅰ and type Ⅱ(FRI&Ⅱ) radio galaxies.Following our previous work,we present a latest sample of 966 sources with measured radio flux densities of the core and extended components.The sample includes 83 BL Lacs,473 flat spectrum radio quasars,101 Seyferts,245 galaxies,52 FRIs&Ⅱs and12 unidentified sources.We then calculate the radio core-dominance parameters and spectral indices and study their relationship.Our analysis shows that the core-dominance parameters and spectral indices are quite different for different types of sources.We also confirm that the correlation between core-dominance parameter and radio spectral index extends over all the sources in a large sample presented.展开更多
Synchrotron radiation sources, whose number is steadily increasing, are undoubtedly the most powerful and brilliant sources in the X-ray range. Although the synchrotron emission covers with high brilliance also the in...Synchrotron radiation sources, whose number is steadily increasing, are undoubtedly the most powerful and brilliant sources in the X-ray range. Although the synchrotron emission covers with high brilliance also the infrared region, its use in this energy range has developed at a much slower rate. Nowadays, after a couple of decades of attempts, the aim of extending the unique performances of the synchrotron source to the infrared domain is achieved by several dedicated beamlines in different countries. With their high-brilliance, polarized and broad-band radiation one may perform experiments that are out of the range of conventional sources from the near-IR up to the far-IR range.展开更多
We show how the star formation activity of galaxies is progressively inhibited from the outer region to the center of the massive cluster A2142.From an extended spectroscopic redshift survey of 2239 galaxies covering ...We show how the star formation activity of galaxies is progressively inhibited from the outer region to the center of the massive cluster A2142.From an extended spectroscopic redshift survey of 2239 galaxies covering a circular area of radius~11 Mpc from the cluster center,we extract a sample of 333 galaxies with known stellar mass,star formation rate,and spectral index D_(n)4000.We use the Blooming Tree algorithm to identify the substructures of the cluster and separate the galaxy sample into substructure galaxies,halo galaxies,and outskirt galaxies.The substructure and halo galaxies are cluster members,whereas the outskirt galaxies are only weakly gravitationally bound to the cluster.For the cluster members,the star formation rate per stellar mass decreases with decreasing distance R from the cluster center.Similarly,the spectral index D_(n)4000 increases with R,indicating an increasing average age of the stellar population in galaxies closer to the cluster center.In addition,star formation in substructure galaxies is generally more active than in halo galaxies and less active than in outskirt galaxies,proving that substructures tend to slow down the transition between field galaxies and cluster galaxies.We finally show that most actively star-forming galaxies are within the cluster infall region,whereas most galaxies in the central region are quiescent.展开更多
“A Craftsman Must Sharpen His Tools to Do His Job,”said Confucius.Nuclear detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the...“A Craftsman Must Sharpen His Tools to Do His Job,”said Confucius.Nuclear detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the universe.Also,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,etc.The article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition Radiation Detector,and Readout Techniques.By explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community.展开更多
Radiative decays D((s))*→D((s))γare revisited in light of new experimental data from the BaBar and BESⅢCollaborations.The radiative couplings gD*Dγencoding nonperturbative QCD effects are calculated in the framewo...Radiative decays D((s))*→D((s))γare revisited in light of new experimental data from the BaBar and BESⅢCollaborations.The radiative couplings gD*Dγencoding nonperturbative QCD effects are calculated in the framework of the covariant confined quark model developed by us.We compare our results with other theoretical studies and experimental data.The couplings(in GeV-1)|g(D*+D+γ)|=0.45(9)and|g(D*0D0γ)|=1.72(34)calculated in our model agree with the corresponding experimental data|g(D*+D+γ)|=0.47(7)and|g(D*0D0γ)|=1.77(16).The most interesting case is the decay Ds*→Dsγ,for which a recent prediction based on light-cone sum rules at next-to-leading order|gDs*Dsγ|=0.60(19)deviates from the first(and only to date)lattice QCD result|gDs*Dsγ|=0.11(2)at nearly3σ.Our calculation yields|gDs*Dsγ|=0.29(6),which falls somehow between the two mentioned results,although it is larger than those predicted in other studies using quark models or QCD sum rules.展开更多
We discuss a novel window to probe the origin of our universe via the mass functions of primordial black holes(PBHs).The mass functions of PBHs are simply estimated using the conventional Press-Schechter formalism for...We discuss a novel window to probe the origin of our universe via the mass functions of primordial black holes(PBHs).The mass functions of PBHs are simply estimated using the conventional Press-Schechter formalism for two paradigms of cosmic origin,including inflationaryΛCDM and bounce cosmology.The standard inflationaryΛCDM model cannot generate an appreciable number of massive PBHs;however,non-trivial inflation models with blue-tilted power spectra at small scales and matter bounce cosmology provide formation mechanisms for heavy PBHs,which in turn,may seed the observed supermassive black holes(SMBHs).By fitting the SMBH mass functions at high redshift(z~6)derived from Sloan Digital Sky Survey(SDSS)and Canada-France High-z Quasar Survey(CFHQS)quasars,for two paradigms of cosmic origin,we derive constraints on the PBH density fraction fPBHat z~6 and the characteristic mass M_(★),with the prior assumption that all SMBHs stem from PBHs.We demonstrate that this newly proposed procedure,relying on astronomical measurements that utilize deep-field surveys of SMBHs at high redshift,can be used to constrain models of cosmic origin.Additionally,although not the main focus of this paper,we evolve the mass function from z~6 to z~0 through an assumption of 3×10^(8)-year Eddington’s accretion,and give a rough estimation of fPBHat z~0.展开更多
Colorectal cancer(CRC) development represents a multistep process starting with specific mutations that affect proto-oncogenes and tumour suppressor genes.These mutations confer a selective growth advantage to colonic...Colorectal cancer(CRC) development represents a multistep process starting with specific mutations that affect proto-oncogenes and tumour suppressor genes.These mutations confer a selective growth advantage to colonic epithelial cells that form first dysplastic crypts, and then malignant tumours and metastases. All these steps are accompanied by deep mechanical changes at the cellular and the tissue level. A growing consensus is emerging that such modifications are not merely a byproduct of the malignant progression, but they could play a relevant role in the cancer onset and accelerate its progression. In this review, we focus on recent studies investigating the role of the biomechanical signals in the initiation and the development of CRC. We show that mechanical cues might contribute to early phases of the tumour initiation by controlling the Wnt pathway, one of most important regulators of cell proliferation in various systems. We highlight how physical stimuli may be involved in the differentiation of non-invasive cells into metastatic variants and how metastatic cells modify their mechanical properties, both stiffness and adhesion, to survive the mechanical stress associated with intravasation, circulation and extravasation. A deep comprehension of these mechanical modifications may help scientist to define novel molecular targets for the cure of CRC.展开更多
Observing GeV gamma-rays is an important goal of the DArk Matter Particle Explorer(DAMPE)for indirect dark matter searching and high energy astrophysics. In this work, we present a set of accurate instrument response ...Observing GeV gamma-rays is an important goal of the DArk Matter Particle Explorer(DAMPE)for indirect dark matter searching and high energy astrophysics. In this work, we present a set of accurate instrument response functions for DAMPE(DmpIRFs) including the effective area, point-spread function and energy dispersion, which are crucial for gamma-ray data analysis based on statistics from simulation data. A dedicated software named DmpST is developed to facilitate the scientific analyses of DAMPE gamma-ray data. Considering the limited number of photons and angular resolution of DAMPE, the maximum likelihood method is adopted in DmpST to better disentangle different source components. The basic mathematics and framework regarding this software are also introduced in this paper.展开更多
文摘The discovery of chirped pulse amplification has led to great improvements in laser technology,enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few micrometers.Protons with energies of tens of MeV can be accelerated using,for instance,target normal sheath acceleration and focused on secondary targets.Under such conditions,nuclear reactions can occur,with the production of radioisotopes suitable for medical application.The use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on accelerators.In this paper,we study the production of^(67)Cu,^(63)Zn,^(18)F,and^(11)C,which are currently used in positron emission tomography and other applications.At the same time,we study the reactions^(10)B(p,α)^(7)Be and^(70)Zn(p,4n)^(67)Ga to put further constraints on the proton distributions at different angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy production.The experiment was performed at the 1 PW laser facility at VegaⅢin Salamanca,Spain.Angular distributions of radioisotopes in the forward(with respect to the laser direction)and backward directions were measured using a high purity germanium detector.Our results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera[Nucl.Instrum.Methods Phys.Res.,Sect.A 637,164–170(2011)].
文摘In this paper we provide evidence that the Cassie-to-Wenzel transition, despite its detrimental effects on the wetting properties of superhydrophobic surfaces, can be exploited as an effective micro-fabrication strategy to obtain highly ordered arrays of biological objects. To this purpose we fabricated a patterned surface wetted in the Cassie state, where we deposited a droplet containing genomic DNA. We observed that, when the droplet wets the surface in the Cassie state, an array of DNA filaments pinned on the top edges between pillars is formed. Conversely, when the Cassie-to-Wenzel transition occurs, DNA can be pinned at different height between pillars. These results open the way to the realization of tridimensional arrays of biological objects.
基金partially supported by the National Natural Science Foundation of China (11733001, U1531245, 10633010 and 11173009)Natural Science Foundation of Guangdong Province (2017A030313011)Astrophysics Key Subjects of Guangdong Province and Guangzhou City
文摘Active galactic nuclei(AGNs) can be divided into two major classes, namely radio-loud and radio-quiet AGNs. A small subset of the radio-loud AGNs is called blazars, which are believed to be unified with Fanaroff-Riley type Ⅰ/Ⅱ(FRI/Ⅱ) radio galaxies. Following our previous work(Fan et al.), we present a sample of 2400 sources with measured radio flux densities of the core and extended components. The sample contains 250 BL Lacs, 520 quasars, 175 Seyferts, 1178 galaxies, 153 FRI or FRⅡ galaxies and 104 unidentified sources. We then calculate the radio core-dominance parameters and spectral indices, and study their relationship. Our analysis shows that the core-dominance parameters and spectral indices are quite different for different types of sources. We also confirm that the correlation between core-dominance parameter and spectral index exists for a large sample presented in this work.
基金National Key Research and Development Program of China(Nos.2016YY0200805 and 2017YFF0206205)Major Program of National Natural Science Foundation of China(No.11790324)National Magnetic Confinement Fusion Science Program of China(Nos.2013GB106004 and 2012GB101003).
文摘The time-of-flight enhanced diagnostics(TOFED)neutron spectrometer has been installed in TOFED house,which is a newly-built neutron diagnostic lab outside the EAST experimental hall.The line of sight(LOS)of TOFED is defined by the collimator going through the 150 cm biological shielding wall,which can reduce background neutrons very effectively for the neutron spectral measurements.The Monte Carlo code MCNP5 is used in the simulations to characterize collimation effects and the radiation safety of the new house.The collimator makes neutron flux almost fully perpendicular to S 1 detectors.In addition,the proportion of scattered neutrons in the LOS of the TOFED is obtained for the measured spectral data interpretation.The simulation results show that the TOFED house satisfies the requirement for the TOFED operations at EAST and gives a safe environment for personnel access during the EAST operation.
基金the National Natural Science Foundation of China under Grant No.19775057the Chinese Academy of Sciences(No.KJ95T-03).
文摘The excitation functions of dissipative products have been measured in the reaction 27Al+27Al at incident energies from 114 to 127MeV in steps of 200keV. Detection angles vary continuously from 10.4° to 57.4° in laboratory system. An angular coherent width more than 40° in center of mass is obtained. The results from the analysis of excitation functions with nonself-averaging are characterized by a quasi-periodic long-range energy structure embedded in the disorder Ericson fluctuation.
基金ongoing support from Guangzhou University,ChinaIstituto Nazionale di Fisica Nucleare,Sezione di Padova,Italy+2 种基金partially supported by the National Natural Science Foundation of China(Grant Nos.11733001and U1531245)the Natural Science Foundation of Guangdong Province(2017A030313011)supports for Astrophysics Key Subjects of Guangdong Province and Guangzhou City
文摘Active galactic nuclei(AGNs) can be divided into two major classes,namely radio-loud and radio-quiet AGNs.A small subset of the radio-loud AGNs is called blazars,which are believed to be unified with Fanaroff-Riley type Ⅰ and type Ⅱ(FRI&Ⅱ) radio galaxies.Following our previous work,we present a latest sample of 966 sources with measured radio flux densities of the core and extended components.The sample includes 83 BL Lacs,473 flat spectrum radio quasars,101 Seyferts,245 galaxies,52 FRIs&Ⅱs and12 unidentified sources.We then calculate the radio core-dominance parameters and spectral indices and study their relationship.Our analysis shows that the core-dominance parameters and spectral indices are quite different for different types of sources.We also confirm that the correlation between core-dominance parameter and radio spectral index extends over all the sources in a large sample presented.
文摘Synchrotron radiation sources, whose number is steadily increasing, are undoubtedly the most powerful and brilliant sources in the X-ray range. Although the synchrotron emission covers with high brilliance also the infrared region, its use in this energy range has developed at a much slower rate. Nowadays, after a couple of decades of attempts, the aim of extending the unique performances of the synchrotron source to the infrared domain is achieved by several dedicated beamlines in different countries. With their high-brilliance, polarized and broad-band radiation one may perform experiments that are out of the range of conventional sources from the near-IR up to the far-IR range.
基金supported by Bureau of International Cooperation,Chinese Academy of Sciences GJHZ1864partial support from the INFN grant InDark。
文摘We show how the star formation activity of galaxies is progressively inhibited from the outer region to the center of the massive cluster A2142.From an extended spectroscopic redshift survey of 2239 galaxies covering a circular area of radius~11 Mpc from the cluster center,we extract a sample of 333 galaxies with known stellar mass,star formation rate,and spectral index D_(n)4000.We use the Blooming Tree algorithm to identify the substructures of the cluster and separate the galaxy sample into substructure galaxies,halo galaxies,and outskirt galaxies.The substructure and halo galaxies are cluster members,whereas the outskirt galaxies are only weakly gravitationally bound to the cluster.For the cluster members,the star formation rate per stellar mass decreases with decreasing distance R from the cluster center.Similarly,the spectral index D_(n)4000 increases with R,indicating an increasing average age of the stellar population in galaxies closer to the cluster center.In addition,star formation in substructure galaxies is generally more active than in halo galaxies and less active than in outskirt galaxies,proving that substructures tend to slow down the transition between field galaxies and cluster galaxies.We finally show that most actively star-forming galaxies are within the cluster infall region,whereas most galaxies in the central region are quiescent.
基金supported by the National Natural Science Foundation of China(No.12222512,U2032209,12075045,12335011,1875097,11975257,62074146,11975115,12205374,12305210,11975292,12005276,12005278,12375193,12227805,12235012,12375191,12005279)the National Key Research and Development Program of China(2021YFA1601300)+13 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(XDB34000000)the CAS Pioneer Hundred Talent Programthe CAS“Light of West China”Programthe Natural Science Foundation of Liaoning Province(No.101300261)the Dalian Science and Technology Innovation Fund(2023JJ12GX013)the Special Projects of the Central Government in Guidance of Local Science and Technology Development(Research and development of three-dimensional prospecting technology based on Cosmic-ray muons)(YDZX20216200001297)the Science and Technology Planning Project of Gansu(20JR10RA645)the Lanzhou University Talent Cooperation Research Funds sponsored by both Lanzhou City(561121203)the Gansu provincial science and technology plan projects for talents(054000029)the Beijing Natural Science Foundation(No.1232033)the Beijing Hope Run Special Fund of Cancer Foundation of China(No.LC2021B23)the Guangdong Major Project of Basic and Applied Basic Research(No.2020B0301030008)the Scientific Instrument Developing Project of the Chinese Academy of Sciences(No.GJJSTD20210009)the Youth Innovation Promotion Association CAS(2021450)。
文摘“A Craftsman Must Sharpen His Tools to Do His Job,”said Confucius.Nuclear detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the universe.Also,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,etc.The article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition Radiation Detector,and Readout Techniques.By explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community.
基金Supported by Ho Chi Minh City University of Technology and Education(T2022-26)。
文摘Radiative decays D((s))*→D((s))γare revisited in light of new experimental data from the BaBar and BESⅢCollaborations.The radiative couplings gD*Dγencoding nonperturbative QCD effects are calculated in the framework of the covariant confined quark model developed by us.We compare our results with other theoretical studies and experimental data.The couplings(in GeV-1)|g(D*+D+γ)|=0.45(9)and|g(D*0D0γ)|=1.72(34)calculated in our model agree with the corresponding experimental data|g(D*+D+γ)|=0.47(7)and|g(D*0D0γ)|=1.77(16).The most interesting case is the decay Ds*→Dsγ,for which a recent prediction based on light-cone sum rules at next-to-leading order|gDs*Dsγ|=0.60(19)deviates from the first(and only to date)lattice QCD result|gDs*Dsγ|=0.11(2)at nearly3σ.Our calculation yields|gDs*Dsγ|=0.29(6),which falls somehow between the two mentioned results,although it is larger than those predicted in other studies using quark models or QCD sum rules.
基金supported in part by the National Key R&D Program of China(Grant No.2021YFC2203100)CAS Young Interdisciplinary Innovation Team(Grant No.JCTD-2022-20)+11 种基金National Natural Science Foundation of China(Grant Nos.11875113,11961131007,12261131497,12003029,11833005,and 12192224)111 Project for“Observational and Theoretical Research on Dark Matter and Dark Energy”(Grant No.B23042)Fundamental Research Funds for Central UniversitiesCSC Innovation Talent FundsUSTC Fellowship for International CooperationUSTC Research Funds of the Double First-Class InitiativeCAS project for young scientists in basic research(Grant No.YSBR-006)Shanghai Municipality Science and Technology Commission(Grant No.KBH1512299)supported by the Disposizione del Presidente INFN n.24433 in INFN Sezione di Milanosupported in part by the U.S.Department of Energy,Office of High Energy Physics(Grant No.DE-SC0019470)the Foundational Questions Institute(Grant No.FQXi-MGB-1927)the use of the computing cluster LINDA&JUDY in the particle cosmology group at USTC。
文摘We discuss a novel window to probe the origin of our universe via the mass functions of primordial black holes(PBHs).The mass functions of PBHs are simply estimated using the conventional Press-Schechter formalism for two paradigms of cosmic origin,including inflationaryΛCDM and bounce cosmology.The standard inflationaryΛCDM model cannot generate an appreciable number of massive PBHs;however,non-trivial inflation models with blue-tilted power spectra at small scales and matter bounce cosmology provide formation mechanisms for heavy PBHs,which in turn,may seed the observed supermassive black holes(SMBHs).By fitting the SMBH mass functions at high redshift(z~6)derived from Sloan Digital Sky Survey(SDSS)and Canada-France High-z Quasar Survey(CFHQS)quasars,for two paradigms of cosmic origin,we derive constraints on the PBH density fraction fPBHat z~6 and the characteristic mass M_(★),with the prior assumption that all SMBHs stem from PBHs.We demonstrate that this newly proposed procedure,relying on astronomical measurements that utilize deep-field surveys of SMBHs at high redshift,can be used to constrain models of cosmic origin.Additionally,although not the main focus of this paper,we evolve the mass function from z~6 to z~0 through an assumption of 3×10^(8)-year Eddington’s accretion,and give a rough estimation of fPBHat z~0.
基金National Natural Science Foundation of China(61575212)Key Research Project of the Frontier Science of the Chinese Academy of Sciences(QYZDB-SSW-JSC022)
文摘Colorectal cancer(CRC) development represents a multistep process starting with specific mutations that affect proto-oncogenes and tumour suppressor genes.These mutations confer a selective growth advantage to colonic epithelial cells that form first dysplastic crypts, and then malignant tumours and metastases. All these steps are accompanied by deep mechanical changes at the cellular and the tissue level. A growing consensus is emerging that such modifications are not merely a byproduct of the malignant progression, but they could play a relevant role in the cancer onset and accelerate its progression. In this review, we focus on recent studies investigating the role of the biomechanical signals in the initiation and the development of CRC. We show that mechanical cues might contribute to early phases of the tumour initiation by controlling the Wnt pathway, one of most important regulators of cell proliferation in various systems. We highlight how physical stimuli may be involved in the differentiation of non-invasive cells into metastatic variants and how metastatic cells modify their mechanical properties, both stiffness and adhesion, to survive the mechanical stress associated with intravasation, circulation and extravasation. A deep comprehension of these mechanical modifications may help scientist to define novel molecular targets for the cure of CRC.
基金supported in part by the National Key Program for Research and Development (2016YFA0400200)the Strategic Priority Research Program of Chinese Academy of Sciences (XDB23040000)+3 种基金the 13th Five-year Informatization Plan of Chinese Academy of Sciences (XXH13506)the National Natural Science Foundation of China (Nos. U1631111, U1738123, U1738136 and U1738210)Youth Innovation Promotion Association of Chinese Academy of Sciencesthe Young Elite Scientists Sponsorship Program
文摘Observing GeV gamma-rays is an important goal of the DArk Matter Particle Explorer(DAMPE)for indirect dark matter searching and high energy astrophysics. In this work, we present a set of accurate instrument response functions for DAMPE(DmpIRFs) including the effective area, point-spread function and energy dispersion, which are crucial for gamma-ray data analysis based on statistics from simulation data. A dedicated software named DmpST is developed to facilitate the scientific analyses of DAMPE gamma-ray data. Considering the limited number of photons and angular resolution of DAMPE, the maximum likelihood method is adopted in DmpST to better disentangle different source components. The basic mathematics and framework regarding this software are also introduced in this paper.