Site condition and bedrock depth play important roles in the determination of peak surface acceleration(PSA)values by earthquake motions.The soil parameters of shear wave velocity(Vs)and standard penetration test-numb...Site condition and bedrock depth play important roles in the determination of peak surface acceleration(PSA)values by earthquake motions.The soil parameters of shear wave velocity(Vs)and standard penetration test-number(N)value for Jakarta city are available up to 100 m below the Earth’s surface even though the typical depths to bedrock are in excess of 100 m.This study referred to the base motion peak ground acceleration(PGA)values of 0.100 g,0.218 g and 0.378 g to predict the PSA values using the Nonlinear Earthquake site Response Analysis(NERA)to analyse a simulated dataset for the bedrock depths of 100 m,200 m,300 m,400 m and 500 m with conditioned by clayey and sandy soils.A new empirical equation of Vs=102.48 N0.297(m/s)was proposed to calculate the values of Vsused as an input parameter in the NERA programme for the prediction of seismic wave propagation.The results showed that the PSA values are dependent on the amplitude of seismic waves,depths of bedrock and the local site conditions.Changes in the PSA values from 41.0%to 51.5%and from 46.1%to 79.8%for the bedrocks overlain by sand,from 20.0%to 42.1%and from 45.9%to 58.8%for the bedrocks overlain by clay with increasing of bedrock depths from 200 m to 300 m and from 400 m to 500 m,respectively,were predicted for a 2500-year return period earthquake.Decreases in the PSA values by 41.0%,51.5%,46.1%,79.8%for the bedrocks overlain by sand and by 20.0%,42.1%,45.9%,58.8%for the bedrocks overlain by clay were predicted for a 2500-year return period earthquake due to the bedrock depth changes of 200 m,300 m,400 m,500 m.Large-magnitude earthquake of Jakarta city has a significant effect on an increase or a decrease of the PSA value with depth of bedrock and may cause the vibration damage to buildings and other constructions on the ground.The analysis of the PSA value and PSA ratio influenced by the PGA value,bedrock depth and local soil conditions will make a contribution to the design of earthquake-safe building for Jakarta city in the future.展开更多
Background: DHF (dengue hemorrhagic fever) is an infectious disease that is caused by dengue virus. To date no specific medicine is available for this disease. Jakarta Province ranks 5th in the incidence of DHF. In...Background: DHF (dengue hemorrhagic fever) is an infectious disease that is caused by dengue virus. To date no specific medicine is available for this disease. Jakarta Province ranks 5th in the incidence of DHF. In 2014, the CI (cumulative incidence) of DHF was 48.7 cases/100,000. In Cipayung sub district (East Jakarta), there were 136 new cases of DHF (CI = 52.1/100,000) in 2015. This study aimed to investigate the determinants of DHF outbreak in Cipayung, East Jakarta. Subjects and Method: This was a cross-sectional study, conducted in Cipayung, East Jakarta. A sample of 594 households were selected at random for this study. The dependent variable was DHF. The independent variables were dweller density, water container drainage, container supervision. The data were collected using questionnaire and observation. The data were analyzed by multiple logistic regression. Results: DHF incidence was affected by container supervision 〈 1 time per week (OR (Odd ratio) = 2.45; 95% CI = 1.57 to 3.84; p 〈 0.001), container drainage 〈 4 times/month (OR = 1.82; 95% CI = 1.19 to 2.79; p = 0.006), dweller density 〈 4 (OR = 0.61; 95% CI = 0.42 to 0.87; p = 0.007). Conclusion: DHF incidence is affected by container supervision 〈 1 time per week, container drainage 〈 4 times/month, dweller density 〈 4.展开更多
Menteng Atas is a sub district (Kelurahan) in Southern Jakarta - Indonesia, under the district (Kecamatan) of Setiabudi. As a common crowded settlement in urban area, this location facing multi problems related to...Menteng Atas is a sub district (Kelurahan) in Southern Jakarta - Indonesia, under the district (Kecamatan) of Setiabudi. As a common crowded settlement in urban area, this location facing multi problems related to physical environment. Built environment with very high density and not well-arranged of fronts and position, also do not meet standards of healthy construction and environment are the main problems of Menteng Atas that brings to disasters such as flooding and fire. This paper explored how members of Menteng Atas community perceive their everyday surroundings within the context of an environment that has rapidly changed, primarily due to urban development. This paper also discuss how far they aware about their environment, the disasters prevention, and what they wants for the future of their environment. The study was start from the inside of the local community. Symbolic communication varies from one situation to the next were founded by studying the accounts, explanations, and social action that are meaningful to a group of people. This paper is trying to present and identify perception of host community on their own environment especially related to disasters prevention, and end up with some recommendations to achieve sustainable housing and settlement at this area.展开更多
Multi-storey housing for low income society is a concept of redevelopment from many alternatives of housing development for slum in Jakarta. However, redevelopment directly or indirectly leads to displacement of low-i...Multi-storey housing for low income society is a concept of redevelopment from many alternatives of housing development for slum in Jakarta. However, redevelopment directly or indirectly leads to displacement of low-income residents. The new residents would be of a higher socio-economic status than the previous occupants. For controlling this phenomenon, a study about the influence of displacement to the successful of sustainable multi-storey housing development for low-income society has been done with descriptive method, observation and literature study. The result of this study give knowledge that displacement always happened when the quality of building and environment is increase, the location of multi-storey housing is near city center and commercial area. Low income society voluntary displaced their units to middle or high income society, because they are not affordable for paying operational and maintenance costs. The government has to make regulations for controlling displacement on multi-storey housing for low-income society and for the successful of sustainable multi-storey housing development in urban area.展开更多
Objective:To elucidate the relationship among knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status among women with infertility.Methods:This questionnaire-based c...Objective:To elucidate the relationship among knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status among women with infertility.Methods:This questionnaire-based cross-sectional study was performed online and offline among women with infertility who visited an infertility clinic in Jakarta,Indonesia.We assessed the patient’s knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status and sociodemographic profile.Results:A total of 178 subjects participated in this study,and most participants(92.6%)had received booster Covid-19 vaccines.From the questionnaire,74.2%had good knowledge,and 99.4%had good attitudes regarding Covid-19;however,only 57.9%of patients had good practices.A weak positive correlation existed between knowledge and attitudes(r=0.11,P=0.13)and a moderate negative correlation between attitudes and practices(r=-0.44,P=0.56).Participants’knowledge about vaccines and infertility was correlated with booster vaccination status(P=0.04).Academic background(P=0.01)and attitudes(P=0.01)were also correlated with booster vaccination status.The significant determinants of hesitance of receiving Covid-19 booster vaccines were high school education or below(OR=0.08,95%CI 0.02-0.36)and poor practices(OR=0.21,95%CI 0.05-0.95).Conclusions:The majority of the participants had received the Covid-19 booster vaccine and had good knowledge and attitudes but poor practices regarding Covid-19.Most participants had poor knowledge about the relationship between infertility and the Covid-19 vaccine.The general population should be more informed and reminded about practices to prevent Covid-19 and the relationship between vaccination and fertility to increase the number of people who receive Covid-19 booster vaccines.展开更多
Problems with clean water in coastal areas alongside an increase in population and community economic activities have diversified community activities.Coastal settlements bordering the high seas are characterized as a...Problems with clean water in coastal areas alongside an increase in population and community economic activities have diversified community activities.Coastal settlements bordering the high seas are characterized as arid areas with a lack of clean water.Here,the use of the range groundwater supply against seawater intrusion means that the water consumed by the community tastes salty and brackish.The availability of abundant seawater,processed through desalination technology,can be used to meet the daily clean water needs of coastal communities.Sustainable development goal(SDG)6 Water and Sanitation is concerned with ensuring that everyone has access to clean water and sanitation.In this regard,desalination technology is considered viable to achieve the SDGs in the environmental sector.Some countries have focused on using desalination technology to achieve target 6.4 by 2030.This goal aims to improve the efficiency of water use to reduce the number of people experiencing clean water scarcity by ensuring a sustainable supply of fresh water.The objective of this study is to examine the application of seawater desalination technology for clean water in the Kingdom of Saudi Arabia(KSA)and Indonesia,and identify the implications of desalination policies in these countries.Comparative studies were conducted using secondary data and literature studies on transforming seawater into clean water with technology.KSA applies seawater desalination technology to meet water needs.However,in Indonesia,policymaking has not holistically examined the potential of using seawater desalination technology for clean water.Until now,unlike in the KSA,Indonesia has not addressed the importance of the use of desalination technology in state policy.展开更多
In this review article,we explore the interplay between obstructive sleep apnea(OSA)and type 2 diabetes mellitus(T2DM),highlighting a significant yet often overlooked comorbidity.We delve into the pathophysiological l...In this review article,we explore the interplay between obstructive sleep apnea(OSA)and type 2 diabetes mellitus(T2DM),highlighting a significant yet often overlooked comorbidity.We delve into the pathophysiological links between OSA and diabetes,specifically how OSA exacerbates insulin resistance and disrupts glucose metabolism.The research examines the prevalence of OSA in diabetic patients and its role in worsening diabetes-related complications.Emphasizing the importance of comprehensive management,including weight control and positive airway pressure therapy,the study advocates integrated approaches to improve outcomes for patients with T2DM and OSA.This review underscores the necessity of recognizing and addressing OSA in diabetes care to ensure more effective treatment and better patient outcomes.展开更多
Yu et al’s study in the World Journal of Gastroenterology(2023)introduced a novel regimen of Vonoprazan-amoxicillin dual therapy combined with Saccharomyces boulardii(S.boulardii)for the rescue therapy against Helico...Yu et al’s study in the World Journal of Gastroenterology(2023)introduced a novel regimen of Vonoprazan-amoxicillin dual therapy combined with Saccharomyces boulardii(S.boulardii)for the rescue therapy against Helicobacter pylori(H.pylori),a pathogen responsible for peptic ulcers and gastric cancer.Vonoprazan is a potassium-competitive acid blocker renowned for its rapid and long-lasting acid suppression,which is minimally affected by mealtime.Compared to proton pump inhibitors,which bind irreversibly to cysteine residues in the H+/K+-ATPase pump,Vonoprazan competes with the K+ions,prevents the ions from binding to the pump and blocks acid secretion.Concerns with increasing antibiotic resistance,effects on the gut microbiota,patient compliance,and side effects have led to the advent of a dual regimen for H.pylori.Previous studies suggested that S.boulardii plays a role in stabilizing the gut barrier which improves H.pylori eradication rate.With an acceptable safety profile,the dual-adjunct regimen was effective regardless of prior treatment failure and antibiotic resistance profile,thereby strengthening the applicability in clinical settings.Nonetheless,S.boulardii comes in various formulations and dosages,warranting further exploration into the optimal dosage for supplementation in rescue therapy.Additionally,larger,randomized,double-blinded controlled trials are warranted to confirm these promising results.展开更多
Objective:To investigate the environmental and social aspects of poverty contributing to malaria incidence in Indonesia from 2016 to 2020.Methods:Random forest regression was used to analyse the independent variables ...Objective:To investigate the environmental and social aspects of poverty contributing to malaria incidence in Indonesia from 2016 to 2020.Methods:Random forest regression was used to analyse the independent variables contributing to malaria incidence.Environmental conditions were extracted from remotely sensed data,including vegetation,land temperature,soil moisture,precipitation,and elevation.In contrast,the social aspects of poverty were obtained from government statistical reports.Results:From 2016 to 2020,the contribution of each environmental and social aspect of poverty to malaria incidence fluctuated annually.Generally,the top three essential variables were people aged 15 years and above,experiencing poverty(variable importance/VI=32.0%),people experiencing poverty who work in the agricultural sector(VI=14.4%),and precipitation(VI=9.8%).It was followed by people experiencing poverty who are unemployed(VI=9.2%),land temperature(VI=5.2%),people experiencing poverty who have low education(VI=8.0%),soil moisture(VI=7.4%),elevation(VI=6.0%),and vegetation(VI=3.8%).Conclusions:Poverty and variables related to climate have become the crucial determinants of malaria in Indonesia.The government must strengthen malaria surveillance through climate change mitigation and adaptation programs and accelerate poverty alleviation programs to support malaria elimination.展开更多
BACKGROUND Adolescent idiopathic scoliosis remains a major problem due to its high incidence,high risk,and high cost.One of the aims of the management in scoliosis is to correct the deformity.Many techniques are avail...BACKGROUND Adolescent idiopathic scoliosis remains a major problem due to its high incidence,high risk,and high cost.One of the aims of the management in scoliosis is to correct the deformity.Many techniques are available to correct scoliosis deformity;however,they are all far from ideal to achieve three-dimensional correction in scoliosis.AIM To develop a set of tools named Scoliocorrector Fatma-UI(SCFUI)to aid threedimensional correction and to evaluate the efficacy,safety,and functional outcome.METHODS This study consists of two stages.In the first stage,we developed the SCFUI and tested it in finite element and biomechanical tests.The second stage was a single-blinded randomized clinical trial to evaluate the SCFUI compared to direct vertebral rotation(DVR).Forty-four subjects with adolescent idiopathic scoliosis were randomly allocated into the DVR group(n=23)and SCFUI group(n=21).Radiological,neurological,and functional outcome was compared between the groups.RESULTS Finite element revealed the maximum stress of the SCFUI components to be between 31.2-252 MPa.Biomechanical analysis revealed the modulus elasticity of SCFUI was 9561324±633277 MPa.Both groups showed improvement in Cobb angle and sagittal profile,however the rotation angle was lower in the SCFUI group(11.59±7.46 vs 18.23±6.39,P=0.001).Neurological and functional outcome were comparable in both groups.CONCLUSION We concluded that SCFUI developed in this study resulted in similar coronal and sagittal but better rotational correction compared to DVR.The safety and functional outcomes were also similar to DVR.展开更多
Objective:The secretome,comprising bioactive chemicals released by mesenchymal stem cells(MSCs),holds therapeutic promise in regenerative medicine.This review aimed to explore the therapeutic potential of the MSC secr...Objective:The secretome,comprising bioactive chemicals released by mesenchymal stem cells(MSCs),holds therapeutic promise in regenerative medicine.This review aimed to explore the therapeutic potential of the MSC secretome in regenerative urology,particularly for treating erectile dysfunction(ED),and to provide an overview of preclinical and clinical research on MSCs in ED treatment and subsequently to highlight the rationales,mechanisms,preclinical investigations,and therapeutic potential of the MSC secretome in this context.Methods:The review incorporated an analysis of preclinical and clinical research involving MSCs in the treatment of ED.Subsequently,it delved into the existing knowledge regarding the MSC secretome,exploring its therapeutic potential.The methods included a comprehensive examination of relevant literature to discern the processes underlying the therapeutic efficacy of the MSC secretome.展开更多
Objective:To comprehensively explore hematopoietic stem cells(HSCs)in human milk,understanding their molecular markers,isolation methods,benefits for infants,and potential medical applications.Methods:We conducted a s...Objective:To comprehensively explore hematopoietic stem cells(HSCs)in human milk,understanding their molecular markers,isolation methods,benefits for infants,and potential medical applications.Methods:We conducted a scoping literature review following the PRISMA-ScR guidelines.This review included studies investigating HSCs in human milk,utilizing molecular markers such as CD34^(+),CD113^(+),and CD117^(+)for characterization.Both in vitro and in vivo studies exploring the morphology,function,and clinical implications of these cells were considered.The diverse range of papers reviewed were indexed in PubMed,Science Direct,Scopus,Sage Journals,and Google Scholar,published between 2010 and 2023.Results:This scoping review explored 577 articles and selected 13 studies based on our inclusion criteria,focusing on HSCs in human milk.Most studies dilute samples prior to HSC isolation,followed by detection using markers such as CD34^(+),CD113^(+),and CD117^(+),with flow cytometry serving as the primary analysis tool,focusing on their isolation and detection methods.While no definitive benefits have been conclusively established,there is a strong belief in the potential of HSCs to positively impact infant immunity,growth,and tissue repair.Conclusions:This review presents significant evidence supporting the presence of HSCs in human milk,identified by markers such as CD34^(+),CD113^(+),and CD117^(+).These cells show considerable potential in enhancing infant health,including immunity,tissue repair,cognitive development,and gastrointestinal health.Despite methodological variations in isolation and detection techniques,the collective findings underscore the potential clinical relevance of HSCs in human milk.Moreover,this review highlights the noninvasive accessibility of human milk as a source of HSCs and emphasizes the need for further research to unlock their therapeutic potential.展开更多
Triassic-Jurassic carbonates widely distributed in Eastern Indonesia are believed as oils source rock. The Mesozoic Tokala Formation exhibit source rock potential, as evidenced by high contents of organic matter. Rece...Triassic-Jurassic carbonates widely distributed in Eastern Indonesia are believed as oils source rock. The Mesozoic Tokala Formation exhibit source rock potential, as evidenced by high contents of organic matter. Recent exploration has been conducted in southeastern Sulawesi, targeting the Mesozoic intervals. Therefore, in this study, we attempted to determine source rock potential of Tokala Formation outcropped in southeastern Sulawesi area and its capability to generate hydrocarbon. Five distinct lithofacies were delineated, emphasizing lithological and mineralogical features: foraminifera wackestone (FW), lime mudstone (LM), massive bioturbated calcareous-argillaceous shale (MBCAS), weakly laminated argillaceous-calcareous shale (WLACS), and strongly laminated calcareous-argillaceous shale (SLCAS). Subsequent analyses showed that carbonate-rich samples (FW and LM facies, >50% CaO) had poor source rock potential. Conversely, shale facies with moderate carbonate content (WLACS, MBCAS, and SLCAS, 15% - 50% CaO) had good to excellent source rock characteristics, qualifying them as preferable source rock. In addition, levels of SiO2 and Al2O3 should not be neglected, as these constituents play important roles in clay mineral adsorption. Laminated shale facies with moderate CaO content tended to be more promising as source rock than bioturbated facies. The shale facies of Tokala Formation indicate prospective source rock horizon.展开更多
This study explored the thermo-chemical properties of industrial hemp hurd with different provenances,maturity stages,and retting protocols.The findings were then compared to hemp hurd used in the fabrication of citri...This study explored the thermo-chemical properties of industrial hemp hurd with different provenances,maturity stages,and retting protocols.The findings were then compared to hemp hurd used in the fabrication of citric acid-bonded ultra-low-density hemp hurd particleboard.Pyrolysis-gas chromatography-mass spectrometry(Py-GC/MS),Fourier-transform infrared spectroscopy(FTIR),and thermogravimetric analysis(TGA)were employed to document the variability of the hurd and comprehend the potential impact on biobased composite applications.The choice of cultivar,maturity stage,and processing modality significantly influenced the chemical composition,presence of functional groups,and thermal stability of the hurd.Py-GC/MS revealed substantial variations in the lignin-to-carbohydrate(L/C)ratio,along with the absence of fatty acids in certain cultivars.While FTIR signals confirmed consistent functional groups,differences in peak intensities were indicative of carbohydrate variations associated with maturity and retting duration,impacting the availability of hydroxyl groups for,i.e.,interparticle bonding in citric acid-based bio-composites.Furthermore,it was observed that shorter retting durations initially enhanced the thermal resistance,but prolonged retting led to accelerated degradation,significantly reducing the hurd’s residual mass.The findings indicated notable differences among the samples,emphasizing the importance of investigating variables such as provenance/cultivar,maturity,and processing modality.This assessment is essential to ensure effective agronomic practices that align the raw material characteristics with the specific requirements of intended applications,such as the fabrication of biobased hemp hurd composites.展开更多
Hepatitis B virus(HBV)infection is a major player in chronic hepatitis B that may lead to the development of hepatocellular carcinoma(HCC).HBV genetics are diverse where it is classified into at least 9 genotypes(A to...Hepatitis B virus(HBV)infection is a major player in chronic hepatitis B that may lead to the development of hepatocellular carcinoma(HCC).HBV genetics are diverse where it is classified into at least 9 genotypes(A to I)and 1 putative genotype(J),each with specific geographical distribution and possible different clinical outcomes in the patient.This diversity may be associated with the precision medicine for HBV-related HCC and the success of therapeutical approaches against HCC,related to different pathogenicity of the virus and host response.This Editorial discusses recent updates on whether the classification of HBV genetic diversity is still valid in terms of viral oncogenicity to the HCC and its precision medicine,in addition to the recent advances in cellular and molecular biology technologies.展开更多
On February 6,2023,two earthquakes with magnitudes of M_(W) 7.8 and M_(W) 7.5 struck southeastern Turkey,causing significant casualties and economic losses.These seismic events occurred along the East Anatolian Fault ...On February 6,2023,two earthquakes with magnitudes of M_(W) 7.8 and M_(W) 7.5 struck southeastern Turkey,causing significant casualties and economic losses.These seismic events occurred along the East Anatolian Fault Zone,a convergent boundary between the Arabian Plate and the Anatolian Subplate.In this study,we analyze the M_(W) 7.8 and M_(W) 7.5 earthquakes by comparing their aftershock relocations,tomographic images,and stress field inversions.The earthquakes were localized in the upper crust and exhibited steep dip angles.Furthermore,the aftershocks occurred either close to the boundaries of low and high P-wave velocity anomaly zones or within the low P-wave velocity anomaly zones.The East Anatolia Fault,associated with the M_(W) 7.8 earthquake,and the SürgüFault,related to the M_(W) 7.5 earthquake,predominantly experienced shear stress.However,their western sections experienced a combination of strike-slip and tensile stresses in addition to shear stress.The ruptures of the M_(W) 7.8 and M_(W) 7.5 earthquakes appear to have bridged a seismic gap that had seen sparse seismicity over the past 200 years prior to the 2023 Turkey earthquake sequence.展开更多
基金the financial support from the Universitas Syiah Kuala and Ministry of Research,Technology and Higher Education,Indonesia,for Professors Research Scheme Grant No.268/UN11/SPK/PNBP/2020 awarded to MMTon Duc Thang University,Vietnam,for Research Funding Contract No.551/2019/TDT-HDLV-NCV awarded to MAF
文摘Site condition and bedrock depth play important roles in the determination of peak surface acceleration(PSA)values by earthquake motions.The soil parameters of shear wave velocity(Vs)and standard penetration test-number(N)value for Jakarta city are available up to 100 m below the Earth’s surface even though the typical depths to bedrock are in excess of 100 m.This study referred to the base motion peak ground acceleration(PGA)values of 0.100 g,0.218 g and 0.378 g to predict the PSA values using the Nonlinear Earthquake site Response Analysis(NERA)to analyse a simulated dataset for the bedrock depths of 100 m,200 m,300 m,400 m and 500 m with conditioned by clayey and sandy soils.A new empirical equation of Vs=102.48 N0.297(m/s)was proposed to calculate the values of Vsused as an input parameter in the NERA programme for the prediction of seismic wave propagation.The results showed that the PSA values are dependent on the amplitude of seismic waves,depths of bedrock and the local site conditions.Changes in the PSA values from 41.0%to 51.5%and from 46.1%to 79.8%for the bedrocks overlain by sand,from 20.0%to 42.1%and from 45.9%to 58.8%for the bedrocks overlain by clay with increasing of bedrock depths from 200 m to 300 m and from 400 m to 500 m,respectively,were predicted for a 2500-year return period earthquake.Decreases in the PSA values by 41.0%,51.5%,46.1%,79.8%for the bedrocks overlain by sand and by 20.0%,42.1%,45.9%,58.8%for the bedrocks overlain by clay were predicted for a 2500-year return period earthquake due to the bedrock depth changes of 200 m,300 m,400 m,500 m.Large-magnitude earthquake of Jakarta city has a significant effect on an increase or a decrease of the PSA value with depth of bedrock and may cause the vibration damage to buildings and other constructions on the ground.The analysis of the PSA value and PSA ratio influenced by the PGA value,bedrock depth and local soil conditions will make a contribution to the design of earthquake-safe building for Jakarta city in the future.
文摘Background: DHF (dengue hemorrhagic fever) is an infectious disease that is caused by dengue virus. To date no specific medicine is available for this disease. Jakarta Province ranks 5th in the incidence of DHF. In 2014, the CI (cumulative incidence) of DHF was 48.7 cases/100,000. In Cipayung sub district (East Jakarta), there were 136 new cases of DHF (CI = 52.1/100,000) in 2015. This study aimed to investigate the determinants of DHF outbreak in Cipayung, East Jakarta. Subjects and Method: This was a cross-sectional study, conducted in Cipayung, East Jakarta. A sample of 594 households were selected at random for this study. The dependent variable was DHF. The independent variables were dweller density, water container drainage, container supervision. The data were collected using questionnaire and observation. The data were analyzed by multiple logistic regression. Results: DHF incidence was affected by container supervision 〈 1 time per week (OR (Odd ratio) = 2.45; 95% CI = 1.57 to 3.84; p 〈 0.001), container drainage 〈 4 times/month (OR = 1.82; 95% CI = 1.19 to 2.79; p = 0.006), dweller density 〈 4 (OR = 0.61; 95% CI = 0.42 to 0.87; p = 0.007). Conclusion: DHF incidence is affected by container supervision 〈 1 time per week, container drainage 〈 4 times/month, dweller density 〈 4.
文摘Menteng Atas is a sub district (Kelurahan) in Southern Jakarta - Indonesia, under the district (Kecamatan) of Setiabudi. As a common crowded settlement in urban area, this location facing multi problems related to physical environment. Built environment with very high density and not well-arranged of fronts and position, also do not meet standards of healthy construction and environment are the main problems of Menteng Atas that brings to disasters such as flooding and fire. This paper explored how members of Menteng Atas community perceive their everyday surroundings within the context of an environment that has rapidly changed, primarily due to urban development. This paper also discuss how far they aware about their environment, the disasters prevention, and what they wants for the future of their environment. The study was start from the inside of the local community. Symbolic communication varies from one situation to the next were founded by studying the accounts, explanations, and social action that are meaningful to a group of people. This paper is trying to present and identify perception of host community on their own environment especially related to disasters prevention, and end up with some recommendations to achieve sustainable housing and settlement at this area.
文摘Multi-storey housing for low income society is a concept of redevelopment from many alternatives of housing development for slum in Jakarta. However, redevelopment directly or indirectly leads to displacement of low-income residents. The new residents would be of a higher socio-economic status than the previous occupants. For controlling this phenomenon, a study about the influence of displacement to the successful of sustainable multi-storey housing development for low-income society has been done with descriptive method, observation and literature study. The result of this study give knowledge that displacement always happened when the quality of building and environment is increase, the location of multi-storey housing is near city center and commercial area. Low income society voluntary displaced their units to middle or high income society, because they are not affordable for paying operational and maintenance costs. The government has to make regulations for controlling displacement on multi-storey housing for low-income society and for the successful of sustainable multi-storey housing development in urban area.
文摘Objective:To elucidate the relationship among knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status among women with infertility.Methods:This questionnaire-based cross-sectional study was performed online and offline among women with infertility who visited an infertility clinic in Jakarta,Indonesia.We assessed the patient’s knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status and sociodemographic profile.Results:A total of 178 subjects participated in this study,and most participants(92.6%)had received booster Covid-19 vaccines.From the questionnaire,74.2%had good knowledge,and 99.4%had good attitudes regarding Covid-19;however,only 57.9%of patients had good practices.A weak positive correlation existed between knowledge and attitudes(r=0.11,P=0.13)and a moderate negative correlation between attitudes and practices(r=-0.44,P=0.56).Participants’knowledge about vaccines and infertility was correlated with booster vaccination status(P=0.04).Academic background(P=0.01)and attitudes(P=0.01)were also correlated with booster vaccination status.The significant determinants of hesitance of receiving Covid-19 booster vaccines were high school education or below(OR=0.08,95%CI 0.02-0.36)and poor practices(OR=0.21,95%CI 0.05-0.95).Conclusions:The majority of the participants had received the Covid-19 booster vaccine and had good knowledge and attitudes but poor practices regarding Covid-19.Most participants had poor knowledge about the relationship between infertility and the Covid-19 vaccine.The general population should be more informed and reminded about practices to prevent Covid-19 and the relationship between vaccination and fertility to increase the number of people who receive Covid-19 booster vaccines.
文摘Problems with clean water in coastal areas alongside an increase in population and community economic activities have diversified community activities.Coastal settlements bordering the high seas are characterized as arid areas with a lack of clean water.Here,the use of the range groundwater supply against seawater intrusion means that the water consumed by the community tastes salty and brackish.The availability of abundant seawater,processed through desalination technology,can be used to meet the daily clean water needs of coastal communities.Sustainable development goal(SDG)6 Water and Sanitation is concerned with ensuring that everyone has access to clean water and sanitation.In this regard,desalination technology is considered viable to achieve the SDGs in the environmental sector.Some countries have focused on using desalination technology to achieve target 6.4 by 2030.This goal aims to improve the efficiency of water use to reduce the number of people experiencing clean water scarcity by ensuring a sustainable supply of fresh water.The objective of this study is to examine the application of seawater desalination technology for clean water in the Kingdom of Saudi Arabia(KSA)and Indonesia,and identify the implications of desalination policies in these countries.Comparative studies were conducted using secondary data and literature studies on transforming seawater into clean water with technology.KSA applies seawater desalination technology to meet water needs.However,in Indonesia,policymaking has not holistically examined the potential of using seawater desalination technology for clean water.Until now,unlike in the KSA,Indonesia has not addressed the importance of the use of desalination technology in state policy.
文摘In this review article,we explore the interplay between obstructive sleep apnea(OSA)and type 2 diabetes mellitus(T2DM),highlighting a significant yet often overlooked comorbidity.We delve into the pathophysiological links between OSA and diabetes,specifically how OSA exacerbates insulin resistance and disrupts glucose metabolism.The research examines the prevalence of OSA in diabetic patients and its role in worsening diabetes-related complications.Emphasizing the importance of comprehensive management,including weight control and positive airway pressure therapy,the study advocates integrated approaches to improve outcomes for patients with T2DM and OSA.This review underscores the necessity of recognizing and addressing OSA in diabetes care to ensure more effective treatment and better patient outcomes.
文摘Yu et al’s study in the World Journal of Gastroenterology(2023)introduced a novel regimen of Vonoprazan-amoxicillin dual therapy combined with Saccharomyces boulardii(S.boulardii)for the rescue therapy against Helicobacter pylori(H.pylori),a pathogen responsible for peptic ulcers and gastric cancer.Vonoprazan is a potassium-competitive acid blocker renowned for its rapid and long-lasting acid suppression,which is minimally affected by mealtime.Compared to proton pump inhibitors,which bind irreversibly to cysteine residues in the H+/K+-ATPase pump,Vonoprazan competes with the K+ions,prevents the ions from binding to the pump and blocks acid secretion.Concerns with increasing antibiotic resistance,effects on the gut microbiota,patient compliance,and side effects have led to the advent of a dual regimen for H.pylori.Previous studies suggested that S.boulardii plays a role in stabilizing the gut barrier which improves H.pylori eradication rate.With an acceptable safety profile,the dual-adjunct regimen was effective regardless of prior treatment failure and antibiotic resistance profile,thereby strengthening the applicability in clinical settings.Nonetheless,S.boulardii comes in various formulations and dosages,warranting further exploration into the optimal dosage for supplementation in rescue therapy.Additionally,larger,randomized,double-blinded controlled trials are warranted to confirm these promising results.
文摘Objective:To investigate the environmental and social aspects of poverty contributing to malaria incidence in Indonesia from 2016 to 2020.Methods:Random forest regression was used to analyse the independent variables contributing to malaria incidence.Environmental conditions were extracted from remotely sensed data,including vegetation,land temperature,soil moisture,precipitation,and elevation.In contrast,the social aspects of poverty were obtained from government statistical reports.Results:From 2016 to 2020,the contribution of each environmental and social aspect of poverty to malaria incidence fluctuated annually.Generally,the top three essential variables were people aged 15 years and above,experiencing poverty(variable importance/VI=32.0%),people experiencing poverty who work in the agricultural sector(VI=14.4%),and precipitation(VI=9.8%).It was followed by people experiencing poverty who are unemployed(VI=9.2%),land temperature(VI=5.2%),people experiencing poverty who have low education(VI=8.0%),soil moisture(VI=7.4%),elevation(VI=6.0%),and vegetation(VI=3.8%).Conclusions:Poverty and variables related to climate have become the crucial determinants of malaria in Indonesia.The government must strengthen malaria surveillance through climate change mitigation and adaptation programs and accelerate poverty alleviation programs to support malaria elimination.
基金The study was reviewed and approved by the Ethical Committee Faculty of Medicine,University of Indonesia(Approval No.KET-615/UN2.F1/ETIK/PPM.00.02/2020)Ethical Committee of Fatmawati General Hospital(Approval No.DM 01.01/VIII.2/1294/2020).
文摘BACKGROUND Adolescent idiopathic scoliosis remains a major problem due to its high incidence,high risk,and high cost.One of the aims of the management in scoliosis is to correct the deformity.Many techniques are available to correct scoliosis deformity;however,they are all far from ideal to achieve three-dimensional correction in scoliosis.AIM To develop a set of tools named Scoliocorrector Fatma-UI(SCFUI)to aid threedimensional correction and to evaluate the efficacy,safety,and functional outcome.METHODS This study consists of two stages.In the first stage,we developed the SCFUI and tested it in finite element and biomechanical tests.The second stage was a single-blinded randomized clinical trial to evaluate the SCFUI compared to direct vertebral rotation(DVR).Forty-four subjects with adolescent idiopathic scoliosis were randomly allocated into the DVR group(n=23)and SCFUI group(n=21).Radiological,neurological,and functional outcome was compared between the groups.RESULTS Finite element revealed the maximum stress of the SCFUI components to be between 31.2-252 MPa.Biomechanical analysis revealed the modulus elasticity of SCFUI was 9561324±633277 MPa.Both groups showed improvement in Cobb angle and sagittal profile,however the rotation angle was lower in the SCFUI group(11.59±7.46 vs 18.23±6.39,P=0.001).Neurological and functional outcome were comparable in both groups.CONCLUSION We concluded that SCFUI developed in this study resulted in similar coronal and sagittal but better rotational correction compared to DVR.The safety and functional outcomes were also similar to DVR.
文摘Objective:The secretome,comprising bioactive chemicals released by mesenchymal stem cells(MSCs),holds therapeutic promise in regenerative medicine.This review aimed to explore the therapeutic potential of the MSC secretome in regenerative urology,particularly for treating erectile dysfunction(ED),and to provide an overview of preclinical and clinical research on MSCs in ED treatment and subsequently to highlight the rationales,mechanisms,preclinical investigations,and therapeutic potential of the MSC secretome in this context.Methods:The review incorporated an analysis of preclinical and clinical research involving MSCs in the treatment of ED.Subsequently,it delved into the existing knowledge regarding the MSC secretome,exploring its therapeutic potential.The methods included a comprehensive examination of relevant literature to discern the processes underlying the therapeutic efficacy of the MSC secretome.
基金supported by the National Research and Innovation Agency of Republic of Indonesia(BRIN)-RIIM Batch-22022 research grants and the Institute of Education Fund Management(Lembaga Pengelola Dana Pendidikan-LPDP).
文摘Objective:To comprehensively explore hematopoietic stem cells(HSCs)in human milk,understanding their molecular markers,isolation methods,benefits for infants,and potential medical applications.Methods:We conducted a scoping literature review following the PRISMA-ScR guidelines.This review included studies investigating HSCs in human milk,utilizing molecular markers such as CD34^(+),CD113^(+),and CD117^(+)for characterization.Both in vitro and in vivo studies exploring the morphology,function,and clinical implications of these cells were considered.The diverse range of papers reviewed were indexed in PubMed,Science Direct,Scopus,Sage Journals,and Google Scholar,published between 2010 and 2023.Results:This scoping review explored 577 articles and selected 13 studies based on our inclusion criteria,focusing on HSCs in human milk.Most studies dilute samples prior to HSC isolation,followed by detection using markers such as CD34^(+),CD113^(+),and CD117^(+),with flow cytometry serving as the primary analysis tool,focusing on their isolation and detection methods.While no definitive benefits have been conclusively established,there is a strong belief in the potential of HSCs to positively impact infant immunity,growth,and tissue repair.Conclusions:This review presents significant evidence supporting the presence of HSCs in human milk,identified by markers such as CD34^(+),CD113^(+),and CD117^(+).These cells show considerable potential in enhancing infant health,including immunity,tissue repair,cognitive development,and gastrointestinal health.Despite methodological variations in isolation and detection techniques,the collective findings underscore the potential clinical relevance of HSCs in human milk.Moreover,this review highlights the noninvasive accessibility of human milk as a source of HSCs and emphasizes the need for further research to unlock their therapeutic potential.
文摘Triassic-Jurassic carbonates widely distributed in Eastern Indonesia are believed as oils source rock. The Mesozoic Tokala Formation exhibit source rock potential, as evidenced by high contents of organic matter. Recent exploration has been conducted in southeastern Sulawesi, targeting the Mesozoic intervals. Therefore, in this study, we attempted to determine source rock potential of Tokala Formation outcropped in southeastern Sulawesi area and its capability to generate hydrocarbon. Five distinct lithofacies were delineated, emphasizing lithological and mineralogical features: foraminifera wackestone (FW), lime mudstone (LM), massive bioturbated calcareous-argillaceous shale (MBCAS), weakly laminated argillaceous-calcareous shale (WLACS), and strongly laminated calcareous-argillaceous shale (SLCAS). Subsequent analyses showed that carbonate-rich samples (FW and LM facies, >50% CaO) had poor source rock potential. Conversely, shale facies with moderate carbonate content (WLACS, MBCAS, and SLCAS, 15% - 50% CaO) had good to excellent source rock characteristics, qualifying them as preferable source rock. In addition, levels of SiO2 and Al2O3 should not be neglected, as these constituents play important roles in clay mineral adsorption. Laminated shale facies with moderate CaO content tended to be more promising as source rock than bioturbated facies. The shale facies of Tokala Formation indicate prospective source rock horizon.
文摘This study explored the thermo-chemical properties of industrial hemp hurd with different provenances,maturity stages,and retting protocols.The findings were then compared to hemp hurd used in the fabrication of citric acid-bonded ultra-low-density hemp hurd particleboard.Pyrolysis-gas chromatography-mass spectrometry(Py-GC/MS),Fourier-transform infrared spectroscopy(FTIR),and thermogravimetric analysis(TGA)were employed to document the variability of the hurd and comprehend the potential impact on biobased composite applications.The choice of cultivar,maturity stage,and processing modality significantly influenced the chemical composition,presence of functional groups,and thermal stability of the hurd.Py-GC/MS revealed substantial variations in the lignin-to-carbohydrate(L/C)ratio,along with the absence of fatty acids in certain cultivars.While FTIR signals confirmed consistent functional groups,differences in peak intensities were indicative of carbohydrate variations associated with maturity and retting duration,impacting the availability of hydroxyl groups for,i.e.,interparticle bonding in citric acid-based bio-composites.Furthermore,it was observed that shorter retting durations initially enhanced the thermal resistance,but prolonged retting led to accelerated degradation,significantly reducing the hurd’s residual mass.The findings indicated notable differences among the samples,emphasizing the importance of investigating variables such as provenance/cultivar,maturity,and processing modality.This assessment is essential to ensure effective agronomic practices that align the raw material characteristics with the specific requirements of intended applications,such as the fabrication of biobased hemp hurd composites.
基金Supported by Rumah Program 2024 of Research Organization for Health,National Research and Innovation Agency of Indonesia2023 Grant of The Fondazione Veronesi,Milan,Italy(Caecilia H C Sukowati)2023/2024 Postdoctoral Fellowship of The Manajemen Talenta,Badan Riset dan Inovasi Nasional,Indonesia(Sri Jayanti).
文摘Hepatitis B virus(HBV)infection is a major player in chronic hepatitis B that may lead to the development of hepatocellular carcinoma(HCC).HBV genetics are diverse where it is classified into at least 9 genotypes(A to I)and 1 putative genotype(J),each with specific geographical distribution and possible different clinical outcomes in the patient.This diversity may be associated with the precision medicine for HBV-related HCC and the success of therapeutical approaches against HCC,related to different pathogenicity of the virus and host response.This Editorial discusses recent updates on whether the classification of HBV genetic diversity is still valid in terms of viral oncogenicity to the HCC and its precision medicine,in addition to the recent advances in cellular and molecular biology technologies.
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.42130312 and 4198810101)the Second Tibetan Plateau Scientific Expedition and Research Program(Grant No.2019QZKK07)
文摘On February 6,2023,two earthquakes with magnitudes of M_(W) 7.8 and M_(W) 7.5 struck southeastern Turkey,causing significant casualties and economic losses.These seismic events occurred along the East Anatolian Fault Zone,a convergent boundary between the Arabian Plate and the Anatolian Subplate.In this study,we analyze the M_(W) 7.8 and M_(W) 7.5 earthquakes by comparing their aftershock relocations,tomographic images,and stress field inversions.The earthquakes were localized in the upper crust and exhibited steep dip angles.Furthermore,the aftershocks occurred either close to the boundaries of low and high P-wave velocity anomaly zones or within the low P-wave velocity anomaly zones.The East Anatolia Fault,associated with the M_(W) 7.8 earthquake,and the SürgüFault,related to the M_(W) 7.5 earthquake,predominantly experienced shear stress.However,their western sections experienced a combination of strike-slip and tensile stresses in addition to shear stress.The ruptures of the M_(W) 7.8 and M_(W) 7.5 earthquakes appear to have bridged a seismic gap that had seen sparse seismicity over the past 200 years prior to the 2023 Turkey earthquake sequence.