Background: Crohns disease is common in highly industrialised Western countries where helminths are rare and uncommon in less developed areas of the world where most people carry worms. Helminths diminish immune res...Background: Crohns disease is common in highly industrialised Western countries where helminths are rare and uncommon in less developed areas of the world where most people carry worms. Helminths diminish immune responsiveness in naturally colonised humans and reduce inflammation in experimental colitis. Thus exposure to helminths may help prevent or even ameliorate Crohns disease. Aims: The aim of the study was to determine the safety and possible efficacy of the intestinal helminth Trichuris suis in the treatment of patients with active Crohns disease. Patients: Twenty nine patients with active Crohns disease, defined by a Crohns disease activity index (CDAI) ≥220 were enrolled in this open label study. Methods: All patients ingested 2500 live T suis ova every three weeks for 24 weeks, and disease activity was monitored by CDAI. Remission was defined as a decrease in CDAI to less than 150 while a response was defined as a decrease in CDAI of greater than 100. Results: At week 24, 23 patients (79.3%) responded (decrease in CDAI >100 points or CDAI < 150) and 21/29 (72.4%) remitted (CDAI < 150). Mean CDAI of responders decreased 177.1 points below baseline. Analysis at week 12 yielded similar results. There were no adverse events. Conclusions: This new therapy may offer a unique, safe, and efficacious alternative for Crohns disease management. These findings also support the premise that natural exposure to helminths such as T suis affords protection from immunological diseases like Crohns disease.展开更多
文摘Background: Crohns disease is common in highly industrialised Western countries where helminths are rare and uncommon in less developed areas of the world where most people carry worms. Helminths diminish immune responsiveness in naturally colonised humans and reduce inflammation in experimental colitis. Thus exposure to helminths may help prevent or even ameliorate Crohns disease. Aims: The aim of the study was to determine the safety and possible efficacy of the intestinal helminth Trichuris suis in the treatment of patients with active Crohns disease. Patients: Twenty nine patients with active Crohns disease, defined by a Crohns disease activity index (CDAI) ≥220 were enrolled in this open label study. Methods: All patients ingested 2500 live T suis ova every three weeks for 24 weeks, and disease activity was monitored by CDAI. Remission was defined as a decrease in CDAI to less than 150 while a response was defined as a decrease in CDAI of greater than 100. Results: At week 24, 23 patients (79.3%) responded (decrease in CDAI >100 points or CDAI < 150) and 21/29 (72.4%) remitted (CDAI < 150). Mean CDAI of responders decreased 177.1 points below baseline. Analysis at week 12 yielded similar results. There were no adverse events. Conclusions: This new therapy may offer a unique, safe, and efficacious alternative for Crohns disease management. These findings also support the premise that natural exposure to helminths such as T suis affords protection from immunological diseases like Crohns disease.
