Leveraging React Components in Business Process Management (BPM) Applications

As organizations increasingly embrace digital transformation, the integration of modern web technologies like React.js with Business Process Management (BPM) applications has become essential. React components offer flexibility, reusability, and scalability, making them ideal for enhancing user interfaces and driving user engagement within BPM environments. This article explores the benefits, challenges, and best practices of leveraging React components in BPM applications, along with real-world examples of successful implementations.

α1 and β1 integrins enhance the homing and differentiation of cultured prostate cancer stem cells

CD133＋ prostate cancer stem cells （PCSCs） have recently been identified in human prostate cancer tissues. The present study reports the integrin profile of prostate cancer progenitor cells and the role of α1 and β1 integrins in the homing and differentiation of PCSCs in vitro. PCSCs were isolated from the tissue specimens of patients with prostate cancer and the expression of surface integrins and adhesion patterns were determined. Our analysis of the expression of surface integrins and their adhesion patterns of prostate cancer stem cells derived from prostate cancer tissues revealed that the levels of β1 and α2β1 integrins were significantly higher （P 〈 0.05） than those of the other integrins. By contrast, peripheral blood-derived CD 133＋ cells from prostate cancer patients showed a high level of expression （P 〈 0.01） of α2β1,αvβ3, αvβ5, β1 and α1 integrins and a minimal expression of α4β1 integrins. Moreover, CD 133＋ cells derived from both prostate cancer tissues and peripheral blood exhibited an increased degree of attachment to extraceUular matrix proteins （P 〈 0.001） and a high expression level of α2β1 integrin. In vitro experiments using blocking antibodies indicated that α1 and β1 integrins have a role in the homing and differentiation of PCSCs. This is the first report to suggest the importance of integrins in mediating the homing and differentiation of PCSCs.

Preparation and Characterization of Nano-Sized (Mg_(x)Fe_(1–x)O/SiO₂) (x = 0.1) Core-Shell Nanoparticles by Chemical Precipitation Method

Magnetic core-shell nanoparticles have been widely studied because of their excellent and convenient magnetic and electrical properties.In this present work core-shell magneticnanoparticles (MNPs) were synthesized by simple chemical precipitation method. Firstly Mg(x)Fe(1–x)O (magnesiwuestite) nano powder samples were synthesised by low temperature chemical combustion method. Secondly the as synthesised Mg(x)Fe(1–x)O nanoparticles are used to synthesis magnetic core-shell Nano particles byusing 2-propanol, poly ethylene glycol (PEG), ammonia solution 30 wt%, tetraethyl orthosilicate (TEOS). Separation of the core-shell magnetic nanoparticles from the aqueous suspension using a centrifuge. The synthesised MNPs and core shell MNP were characterized by X-ray diffraction (XRD), Thermal gravimetric-differential thermal analyzer (TG-DTA), Transmission electron microscopy (TEM), scanning electron microscopy (SEM), (EDAX) for structural, thermal and morphological respectively. It is observed that the particle size of spherical sampleis 32.5 nm.

Separation of Enantiomers of Clopidogrel on Chiral Stationary Phases by Packed Column Supercritical Fluid Chromatography

A packed column supercritical fluid chromatography (SFC) method for the separation of clopidogrel enantiomers on a chiral stationary phase and CO2 with modifier as mobile phase has been developed at an analytical scale. Among 11 different 2 stationary phases the Chiral cel OD-H column showed by far the best separation properties. The influence of different modifiers, injection solvents, temperature, and pressure, and density of the fluid, respectively, on the separation behaviour has been studied. It was found that the separation behaviour strongly depends on the type of modifier and the modifier content. Temperature and pressure are of less influence.

Isolation and Characterization of R-Enantiomer in Ezetimibe

A simple and rapid Supercritical Fluid Chromatography (SFC) method has been developed to isolate and characterize R-Isomer of Ezetimi be by using normal phase Chiral Cel OD-H with 250 mm × 30 mm, 5 microns column using a mobile phase system containing super critical fluid carbondi oxide (Co2) and the percentage of 2-Propanol as a mobile phase (85:15) and detection at 230 nm. The isolated R-Isomer is characterized by using UV-vis, FT-IR, ESI-MS, HPLC1H and 13C NMR. The purity of isolated R-Isomer is about 98%.

Protective effect of Luffa acutangula extracts on gastric ulceration in NIDDM rats:Role of gastric mucosal glycoproteins and antioxidants

Objective:To study the comparative gastroprotective effect of Luffa acutangula methanolic extract(LAM) and aqueous extract(LAW) on typeⅡdiabetes rats.Methods:Streptozotocin(65 mg/kg,Lp.) along with nicotinamide(120 mg/kg,Lp.) was used to induce non insulin dependent diabetes mellitus(NIDDM) in rats.A daily oral dose of aspirin(200 mg/kg,Lp.) was administered for initial seven days to induce gastric ulcerations in the diabetic rats.LAM and LAW were administered orally in the doses of 100,200 and 400 mg/kg once daily for 21 days.Clibenclamide and ranitidine were used as standards for comparing the antidiabetic and antiulcer effect respectively.Results:LAM significantly(P【0.01) increased mucosal glycoprotein and antioxidant enzyme level in gastric mucosa of diabetic rats than LAW(P 【0.05).LAM was efficient in reversing the delayed healing of gastric ulcer in diabetic rats close to the normal level.LAM exhibited better ulcer healing effect than glibenclamide and LAW,because of its both antihyperglycemic and mucosal defensive actions.Conclusions:Thus,LAM is proved to be a better alternative for treating gastric ulcers co-occurring with diabetes.

X-Ray Analysis by Williamson-Hall and Size-Strain Plot Methods of ZnO Nanoparticles with Fuel Variation

In this paper, a simple and facile surfactant assisted combustion synthesis is reported for the ZnO nanoparticles. The synthesis of ZnO-NPs has been done with the assistance of non-ionic surfactant TWEEN 80. The effect of fuel variations and comparative study of fuel urea and glycine have been studied by using characterization techniques like X-ray diffraction (XRD), transmission electron microscope (TEM) and particle size analyzer. From XRD, it indicates the presence of hexagonal wurtzite structure for ZnO-NPs. Using X-ray broadening, crystallite sizes and lattice strain on the peak broadening of ZnO-NPs were studied by using Williamson-Hall (W-H) analysis and size-strain plot. Strain, stress and energy density parameters were calculated for the XRD peaks of all the samples using (UDM), uniform stress deformation model (USDM), uniform deformation energy density model (UDEDM) and by the size-strain plot method (SSP). The results of mean particle size showed an inter correlation with W-H analysis, SSP, particle analyzer and TEM results.

Development and Validation of a Stability-Indicating RP-HPLC Method for Determination of Darifenacin Hydrobromide in Bulk Drugs

An isocratic stability-indicating reversed phase high performance liquid chromatographic method (RP-HPLC) was developed for determination of process related impurities and assay of darifenacin hydrobromide (DRF) in bulk drugs. DRF was subjected to various stress conditions such as hydrolysis (acid, base, and neutral), oxidation, photolysis and thermal degradation as per International Conference on Harmonization (ICH Q1A(R2) and Q1B) prescribed conditions to investigate the stability-indicating ability of the method. Significant degradation was observed during acidic hydrolysis and oxidative stress conditions. The chromatographic separation was accomplished on a Prodigy C8 column (250 × 4.6 mm, 5 μm) with mobile phase consisting of 0.05 M ammonium acetate (pH adjusted to 7.2 by using ammonia solution) and methanol (36% acetonitrile) in 35:65 v/v ratio in an isocratic elution mode at a flow rate of 1.0 mL/min at 25°C. Detection of analytes was carried out using photo diode array detector at a wavelength of 215 nm. The developed LC method was validated with respect to accuracy, linearity, precision, limits of detection and quantitation and robustness as per ICH guidelines.

Analysis of Multi-Component Non-Stationary Signals Using Fourier-Bessel Series and Wigner-Hough Transform

We presented a novel Fourier-Bessel（FB）series and Wigner-Hough transform（WHT） method for the analysis of multi-component non-stationary signals.The FB series decomposed multi-component nonstationary signals into mono-component signals. The Wigner-Ville distribution（WVD） was applied to each mono-component signal to analyze its time-frequency distribution（TFD）. Summing up the WVDs of the individual components resulted in TFDs of the multicomponent signals, where the cross terms and noise were significantly reduced. The Hough transform（HT）was applied on the TFD of the multi-component signal（obtained from FB-WVD）. The HT provides an important tool for mapping the signals onto a parameter space where the detection and estimation problems are made easier. This mapping can be used in the detection and parameter estimation of signals which are unknown and embedded in noise.

Isolation and Characterization of S-Enantiomer in Montelukast

A simple and rapid Supercritical Fluid Chromatography (SFC) Method has been developed to isolate and characterize the S-Isomer of Montelukast by using normal phase Amylose based AS-H with 250 mm × 30 mm, 5 microns column using a mobile phase system containing super critical fluid carbon dioxide (CO2) and the percentage of 2-Propanol as a mobile phase (85:15) and detection at 230 nm. The isolated S-Isomer was characterized by using FT-IR, ESI-MS, HPLC and 1H NMR. The purity of isolated S-Isomer is about 98%.

Simultaneous and Trace Level Quantification of Five Potential Genotoxic Impurities in Ranolazine Active Pharmaceutical Ingredient Using LC-MS/MS

Highly sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed for the simultaneous determination of five potential genotoxic impurities in ranolazine active pharmaceutical ingredient. Chromatographic separation achieved using Poroshell C18 PFP 150 × 3.0 mm 2.7 μ column and 0.1% formic acid in water as Mobile phase A and 0.1% formic acid in methanol as mobile phase B using gradient elution and a flow rate of 0.4 ml/min with a run time of 18 minutes. Mass spectrometric conditions were optimized using electrospray ionization in positive mode. Method shows excellent linearity from 0.05 - 5.0 ppm of the ranolazine test concentration for all the five impurities. The correlation coefficient was observed greater than 0.99. Satisfactory recoveries were observed for all the five impurities within the range of 102.9% - 112.3%. Method has been validated as per ICH recommended guidelines with a LOQ of 0.15 ppm achieved. The developed method was able to quantify all the five impurities at a concentration level of 1 ng/ml (0.5 ppm with respect to 2 mg/ml ranolazine).

Ultra-Sensitive LC-MS/MS Method for the Trace Level Quantification of Six Potential Genotoxic Nitrosamine Impurities in Telmisartan

Nitrosamine impurities are potentially genotoxic which are considered under cohort of concern as per ICH M7 guidelines and need to be controlled at trace levels during quantification in drug substances and drug products for safe human consumption. Recent regulatory requirements also suggest the need to have highly sensitive analytical methods for the accurate quantification of Nitrosamine impurities. In this paper we have presented simple, rapid and ultra-sensitive LC-MS/MS method for six potential genotoxic nitrosamine impurities: N-Nitroso dimethyl amine (NDMA), N-Nitroso diethyl amine (NDEA), N-Nitroso Ethyl Iso propylamine (NEIPA), N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) N-Nitroso diisopropylamino (NDIPA) and N-Nitroso dibutyl amine (NDBA) with a LOQ of 0.004 ppm. Chromatographic separation is achieved using Zorbax SB C18 150 × 3.0 mm, 3.5 μ column with 0.1% formic acid in water as mobile phase A and 0.1% formic acid in methanol as mobile phase B at a flow rate of 0.3 ml/min using gradient mode of elution at a total run time of 18 minutes. Six nitrosamine impurities are successfully ionized and quantified in positive mode of atmospheric pressure chemical ionization (APCI) using multiple reaction monitoring (MRM). Method validation is performed as per ICH guidelines evaluating the limit of quantification and detection and found to give good S/N ratios with good linearity range of 0.002 - 2 ppm with regression coefficient >0.99 for all the six nitrosamine impurities. Method recoveries are established using three-step sample preparation protocol and are found to be satisfactory within 80% - 120%. The method can be used routinely applied for the detection of Nitrosamines in Telmisartan at a concentration of 1.5 ng/ml (0.03 ppm with respect to telmisartan concentration of 50 mg/ml).

Synthesis of ZnO Nanoparticles by a Novel Surfactant Assisted Amine Combustion Method

The as precursor, HMTA as fuel material and non-ionic surfactant (Triton-X 100). The X-Ray diffraction (XRD) analysis revealed that the synthesized ZnO nanopowder has the pure wurtzite structure. The ZnO powder shows polycrystalline nature having the crystallite size 21.25 nm. Crystallite size is calculated using Debye-Scherrer’s and Williamson-Hall equations. Porosity, Cell Volume, Micro strain, Morphology Index, Lorentz factor and Lorentz Polarization factor are also studied. From differential thermal analysis (DTA) & thermo gravimetric (TGA) it has been confirmed that nano powder has the phase purity. The weight loss percentage of the sample is 2.8385%. The particle size obtained 29 nm is in good agreement with the crystallite size calculated from X-Ray Diffraction pattern with the Particle Size Analyzer. The morphology of as prepared Zinc oxide nanopowders are characterized by scanning electron microscope (SEM). From specific area electron diffraction (SAED) pattern has specified the d-spacing and corresponding planes which coincide with the XRD d-spacing and planes.

Structural and Electrical Conductivity Studies in Nickel-Zinc Ferrite

The magnetic particles of nickel-zinc ferrite with chemical composition Ni1-xZnxFe2O4 were synthesized successfully by citrate precursor auto-combustion method using high purity nitrates and citric acid as chelating agent. The prepared powder of nickel-zinc ferrites was sintered at 1000℃ for 1 hr to obtain good crystalline phase and was used for further study. The X-ray diffraction technique was employed to confirm the single phase formation of nickel ferrite. The X-ray diffraction pattern shows the Bragg’s peak which belongs to cubic spinel structure. The values of lattice constant, X-ray density, bulk density, and porosity were calculated. The temperature dependence of the electrical conductivity plot shows the kink, which can be attributed to ferromagnetic-paramagnetic transition. The activation energy obtained from resistivity plots in paramagnetic region is found to be more than that in ferrimagnetic region. The conduction mechanism in nickel-zinc ferrite particles has been discussed on the basis of hopping of electrons.

Impact of Cyclone Nilam on Tropical Lower Atmospheric Dynamics

A deep depression formed over the Bay of Bengal on 28 October 2012, and developed into a cyclonic storm. After landfall near the south coast of Chennai, cyclone Nilam moved north-northwestwards. Coordinated experiments were conducted from the Indian stations of Gadanki（13.5？N, 79.2？E） and Hyderabad（17.4？N, 78.5？E） to study the modification of gravity-wave activity and turbulence by cyclone Nilam, using GPS radiosonde and mesosphere–stratosphere–troposphere radar data. The horizontal velocities underwent large changes during the closest approach of the storm to the experimental sites. Hodograph analysis revealed that inertia gravity waves（IGWs） associated with the cyclone changed their directions from northeast（control time） to northwest following the path of the cyclone. The momentum flux of IGWs and short-period gravity waves（1–8 h） enhanced prior to, and during, the passage of the storm（±0.05 m2s-2and ±0.3 m2s-2, respectively）, compared to the flux after its passage. The corresponding body forces underwent similar changes, with values ranging between ±2–4m s-1d-1and ±12–15 m s-1d-1. The turbulence refractivity structure constant（C2n） showed large values below 10 km before the passage of the cyclone when humidity in the region was very high. Turbulence and humidity reduced during the passage of the storm when a turbulent layer at ～17 km became more intense. Turbulence in the lower troposphere and near the tropopause became weak after the passage of the cyclone.

Oscillatory-Plus-Transient Signal Decomposition Using TQWT and MCA

This paper describes a method for decomposing a signal into the sum of an oscillatory component and a transient component. The process uses the tunable Q-factor wavelet transform (TQWT): The oscillatory component is modeled as a signal that can be sparsely denoted by high Q-factor TQWT;similarly, the transient component is modeled as a piecewise smooth signal that can be sparsely denoted using low Q-factor TQWT. Since the low and high Q-factor TQWT has low coherence, the morphological component analysis (MCA) can effectively decompose the signal into oscillatory and transient components. The corresponding optimization problem of MCA is resolved by the split augmented Lagrangian shrinkage algorithm (SALSA). The applications of the proposed method to speech, electroencephalo-graph (EEG), and electrocardiograph (ECG) signals are included.

TEC and Instrumental Bias Estimation of GAGAN Station Using Kalman Filter and SCORE Algorithm

The standalone Global Positioning System (GPS) does not meet the higher accuracy requirements needed for approach and landing phase of an aircraft. To meet the Category-I Precision Approach (CAT-I PA) requirements of civil aviation, satellite based augmentation system (SBAS) has been planned by various countries including USA, Europe, Japan and India. The Indian SBAS is named as GPS Aided Geo Augmented Navigation (GAGAN). The GAGAN network consists of several dual frequency GPS receivers located at various airports around the Indian subcontinent. The ionospheric delay, which is a function of the total electron content (TEC), is one of the main sources of error affecting GPS/SBAS accuracy. A dual frequency GPS receiver can be used to estimate the TEC. However, line-of-sight TEC derived from dual frequency GPS data is corrupted by the instrumental biases of the GPS receiver and satellites. The estimation of receiver instrumental bias is particularly important for obtaining accurate estimates of ionospheric delay. In this paper, two prominent techniques based on Kalman filter and Self-Calibration Of pseudo Range Error (SCORE) algorithm are used for estimation of instrumental biases. The estimated instrumental bias and TEC results for the GPS Aided Geo Augmented Navigation (GAGAN) station at Hyderabad (78.47°E, 17.45°N), India are presented.

Study of the Dielectric Behaviour of Cr-Doped Zinc Nano Ferrites Synthesized by Sol-Gel Method

The series of Cr-Zn nano ferrites having the general composition CrxZnFe2-xO4 (0 ≤ x ≤ 0.5) have been synthesized successfully in the nanocrystalline form using the sol-gel method. The samples were sintered at 900°C for 3 hours. The effect of chromium substitution on dielectric properties of Zn-ferrites is reported in this paper. The analysis of XRD patterns revealed the formation of single phase cubic spinel structure for all the Cr-Zn ferrite samples. The FTIR spectra show two strong absorption bands in the range of 400 - 600 cm-1, which corroborate the spinel structure of the samples. The average grain size was found to be in the nanometer range and of the order of 43 - 63 nm obtained using TEM images. The lattice parameter and crystallite size decrease with increase in Cr concentration (x). The investigation on dielectric constant (ε'), dissipation factor (D) and ac conductivity (σac) was carried out at a fixed frequency 1 kHz and in the frequency range of 100 Hz to 1 MHz at room temperature using LCR meter. The plots of dielectric constant (ε') versus frequency show the normal dielectric behavior of spinel ferrites. The value of ac conductivity (σac) increases with increase in frequency for all the compositions. The appearance of the peak for each composition in the dissipation factor versus frequency curve suggests the presence of relaxing dipoles in the Cr-Zn nano ferrite samples. It is also found that the shifting of the relaxation peak towards lower frequency side with an increase in chromium content (x) is due to the strengthening of dipole-dipole interactions. The composition and frequency dependence of the dielectric constant, dielectric loss and ac-conductivity are explained based on the Koop’s two-layer model, Maxwell-Wagner polarization process, and Debye relaxation theory.

Carobomer Based Controlled Release Designs of Atorvastatin Calcium Tablets Evaluated Using Quality by Design (QbD) Approach

The study carried out here was focused on developing conventional monolithic controlled release matrix tablet of Atorvastatin calcium using carbomer as release controlling polymer. This system ensures the drug release at the alkaline pH region where the drug has got maximum solubility. Further the study was concentrated on comparing the impact of gelling agent polyvinyl pyrrolidone on drug release. Quality by design tools were considered during formulation development and the polymer concentrations were optimized adopting the statistical tool, design of experiments (DoE). The optimized formulation of present study exhibited desired controlled drug release characteristics in the alkaline pH conditions and at acidic environment the drug dissolution was minimal as intended.

Particle Swarm Optimized Optimal Threshold Value Selection for Clustering based on Correlation Fractal Dimension

The work on the paper is focused on the use of Fractal Dimension in clustering for evolving data streams. Recently Anuradha et al. proposed a new approach based on Relative Change in Fractal Dimension (RCFD) and damped window model for clustering evolving data streams. Through observations on the aforementioned referred paper, this paper reveals that the formation of quality cluster is heavily predominant on the suitable selection of threshold value. In the above-mentionedpaper Anuradha et al. have used a heuristic approach for fixing the threshold value. Although the outcome of the approach is acceptable, however, the approach is purely based on random selection and has no basis to claim the acceptability in general. In this paper a novel method is proposed to optimally compute threshold value using a population based randomized approach known as particle swarm optimization (PSO). Simulations are done on two huge data sets KDD Cup 1999 data set and the Forest Covertype data set and the results of the cluster quality are compared with the fixed approach. The comparison reveals that the chosen value of threshold by Anuradha et al., is robust and can be used with confidence.