Peptide hydrogels have been widely used for diverse biomedical applications. However, our current understanding of the physical principles underlying the self-assembly process is still limited. In this review, we summ...Peptide hydrogels have been widely used for diverse biomedical applications. However, our current understanding of the physical principles underlying the self-assembly process is still limited. In this review, we summarize our current understanding on the physical chemistry principles from the basic interactions that drive the self-assembly process to the energy landscapes that dictate the thermodynamics and kinetics of the process. We discuss the effect of different factors that affect the kinetics of the self-assembly of peptide fibrils and how this is related to the macroscopic gelation process. We provide our understanding on the molecular origin of the complex and rugged energy landscape for the self-assembly of peptide hydrogels. The hierarchical self-assembled structures and the diverse self-assembling mechanism make it difficult and challenging to rationally design the physical and chemical properties of peptide hydrogels at the molecular revel. We also give our personal perspective to the potential future directions in this field.展开更多
It remains challenging to develop methods that can precisely control the self-assembling kinetics and thermodynamics of peptide hydrogelators to achieve hydrogels with optimal properties.Here we report the hydrogelati...It remains challenging to develop methods that can precisely control the self-assembling kinetics and thermodynamics of peptide hydrogelators to achieve hydrogels with optimal properties.Here we report the hydrogelation of peptide hydrogelators by an enzymatically induced pH switch,which involves the combination of glucose oxidase and catalase with D-glucose as the substrate,in which both the gelation kinetics and thermodynamics can be controlled by the concentrations of D-glucose.This novel hydrogelation method could result in hydrogels with higher mechanical stability and lower hydrogelation concentrations.We further illustrate the application of this hydrogelation method to differentiate different D-glucose levels.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos.21522402 and 11304156)the Fundamental Research Funds for the Central Universities(Nos.020414380070,020414380050 and 020414380058)
文摘Peptide hydrogels have been widely used for diverse biomedical applications. However, our current understanding of the physical principles underlying the self-assembly process is still limited. In this review, we summarize our current understanding on the physical chemistry principles from the basic interactions that drive the self-assembly process to the energy landscapes that dictate the thermodynamics and kinetics of the process. We discuss the effect of different factors that affect the kinetics of the self-assembly of peptide fibrils and how this is related to the macroscopic gelation process. We provide our understanding on the molecular origin of the complex and rugged energy landscape for the self-assembly of peptide hydrogels. The hierarchical self-assembled structures and the diverse self-assembling mechanism make it difficult and challenging to rationally design the physical and chemical properties of peptide hydrogels at the molecular revel. We also give our personal perspective to the potential future directions in this field.
基金supported by the National Natural Science Foundation of China(Grant No.11304156)the Priority Academic Program Development of Jiangsu Higher Education,Jiangsu PhD Gathering Scheme,the Technology Foundation for Selected Overseas Chinese Scholar,and the Scientific Research Foundationfor the Returned Overseas Chinese Scholars,State Education Ministry,China
文摘It remains challenging to develop methods that can precisely control the self-assembling kinetics and thermodynamics of peptide hydrogelators to achieve hydrogels with optimal properties.Here we report the hydrogelation of peptide hydrogelators by an enzymatically induced pH switch,which involves the combination of glucose oxidase and catalase with D-glucose as the substrate,in which both the gelation kinetics and thermodynamics can be controlled by the concentrations of D-glucose.This novel hydrogelation method could result in hydrogels with higher mechanical stability and lower hydrogelation concentrations.We further illustrate the application of this hydrogelation method to differentiate different D-glucose levels.
