Objective To investigate the effect of clonal hematopoiesis (CH) in remission on hematopoiesis recovery in patients with NPM1 mutated acute myeloid leukemia (AML) after chemotherapy.Methods Retrospective analysis was ...Objective To investigate the effect of clonal hematopoiesis (CH) in remission on hematopoiesis recovery in patients with NPM1 mutated acute myeloid leukemia (AML) after chemotherapy.Methods Retrospective analysis was performed on 86 patients with NPM1^(mut) AML newly diagnosed and treated in the First Affiliated Hospital of Soochow University between July2016 and June 2019.Their clinical data and NGS test results at diagnosis were analyzed.展开更多
Objective To explore the efficacy and safety of Venetoclax combined with multidrug chemotherapy in patients with relapsed or refractory early T-cell precursor acute lymphoblastic leukemia(R/R ETP-ALL).Methods This stu...Objective To explore the efficacy and safety of Venetoclax combined with multidrug chemotherapy in patients with relapsed or refractory early T-cell precursor acute lymphoblastic leukemia(R/R ETP-ALL).Methods This study retrospectively analyzed 15 patients with R/R ETP-ALL who received Venetoclax combined with multidrug chemotherapy from December 2018 to February 2022.展开更多
Objective To assess the clinical characteristics and prognosis of patients with SIL-TAL1-positive T-cell acute lymphoblastic leukemia(T-ALL).Methods The clinical data of 19 SIL-TAL1-positive T-ALL patients admitted to...Objective To assess the clinical characteristics and prognosis of patients with SIL-TAL1-positive T-cell acute lymphoblastic leukemia(T-ALL).Methods The clinical data of 19 SIL-TAL1-positive T-ALL patients admitted to the First Affiliated Hospital of Soochow University between January 2014 and February 2022 were retrospectively computed and contrasted with SIL-TAL1-negative T-ALL patients.Results The median age of the19 SIL-TAL1-positive T-ALL patients was 15(7 to41 years),including 16 males(84.2%).SIL-TAL1-positive T-ALL patients had younger age,higher WBC,and hemoglobin compared with SIL-TAL1-negative TALL patients.There was no discrepancy in gender distribution,PLT,chromosome abnormality distribution,immunophenotyping,and complete remission(CR)rate.The 3-year overall survival(OS) was 60.9% and74.4%,respectively(HR=2.070,P=0.071).The3-year relapse-free survival(RFS) was 49.2% and70.6%,respectively(HR=2.275,P=0.040).展开更多
Objective To find out the distributed characteristics of KIR2DL1 alleles frequencies and the recognition HLAC ligand in the Chinese Han population.Methods The111 patients and 116 donors from CMDP were performed the KI...Objective To find out the distributed characteristics of KIR2DL1 alleles frequencies and the recognition HLAC ligand in the Chinese Han population.Methods The111 patients and 116 donors from CMDP were performed the KIR2DL1 high-resoluction typing and KIR genotyping using sequence-based testing(SBT)and PCR-SSP methods.Results A total of展开更多
Objective To explore the influence of the killer cell immunoglobulin like receptor(KIR)gene polymorphism on cytomegalovirus(CMV)infection and pathogenesis after hematopoietic stem cell transplantation(HSCT)
Objective To evaluate the efficacy of auto-HSCT and allo-HSCT in the treatment of high risk peripheral T cell lymphoma(PTCL).Methods From July 2007 to July 2014,60 cases of high risk PTCL were analyzed retrospectively...Objective To evaluate the efficacy of auto-HSCT and allo-HSCT in the treatment of high risk peripheral T cell lymphoma(PTCL).Methods From July 2007 to July 2014,60 cases of high risk PTCL were analyzed retrospectively.Results All 60 patients were at high risk group(carried with IPI≥3),with a median age of展开更多
Objective To evaluate the prognostic significance of minimal residual disease(MRD)monitoring by 10-color flow cytometry in multiple myeloma(MM)patients after treatment.Methods 150 patients with MM who were admitted to...Objective To evaluate the prognostic significance of minimal residual disease(MRD)monitoring by 10-color flow cytometry in multiple myeloma(MM)patients after treatment.Methods 150 patients with MM who were admitted to the First Affiliated Hospital of Soochow University from July 2015 to July 2017 were retrospectively analyzed.展开更多
Objective To investigate EVI1 expression and its associated clinical and cytogenetic characteristics in 447acute myeloid leukemia(AML)patients.Methods EVI1expressions were measured in 447 AML cases from Jan.2007 to Ap...Objective To investigate EVI1 expression and its associated clinical and cytogenetic characteristics in 447acute myeloid leukemia(AML)patients.Methods EVI1expressions were measured in 447 AML cases from Jan.2007 to Apr.2015 to couple with clinical。展开更多
Objective By analyzing the risk factors for occurrence of differentiation syndrome(DS)during induction therapy in newly-diagnosed acute promyelocytic leukemia(APL)patients,a prediction nomogram for DS was established ...Objective By analyzing the risk factors for occurrence of differentiation syndrome(DS)during induction therapy in newly-diagnosed acute promyelocytic leukemia(APL)patients,a prediction nomogram for DS was established and the accuracy of this nomogram was validated.Methods The modeling group was made up of 130classical APL patients during the period of 1st。展开更多
文摘Objective To investigate the effect of clonal hematopoiesis (CH) in remission on hematopoiesis recovery in patients with NPM1 mutated acute myeloid leukemia (AML) after chemotherapy.Methods Retrospective analysis was performed on 86 patients with NPM1^(mut) AML newly diagnosed and treated in the First Affiliated Hospital of Soochow University between July2016 and June 2019.Their clinical data and NGS test results at diagnosis were analyzed.
文摘Objective To explore the efficacy and safety of Venetoclax combined with multidrug chemotherapy in patients with relapsed or refractory early T-cell precursor acute lymphoblastic leukemia(R/R ETP-ALL).Methods This study retrospectively analyzed 15 patients with R/R ETP-ALL who received Venetoclax combined with multidrug chemotherapy from December 2018 to February 2022.
文摘Objective To assess the clinical characteristics and prognosis of patients with SIL-TAL1-positive T-cell acute lymphoblastic leukemia(T-ALL).Methods The clinical data of 19 SIL-TAL1-positive T-ALL patients admitted to the First Affiliated Hospital of Soochow University between January 2014 and February 2022 were retrospectively computed and contrasted with SIL-TAL1-negative T-ALL patients.Results The median age of the19 SIL-TAL1-positive T-ALL patients was 15(7 to41 years),including 16 males(84.2%).SIL-TAL1-positive T-ALL patients had younger age,higher WBC,and hemoglobin compared with SIL-TAL1-negative TALL patients.There was no discrepancy in gender distribution,PLT,chromosome abnormality distribution,immunophenotyping,and complete remission(CR)rate.The 3-year overall survival(OS) was 60.9% and74.4%,respectively(HR=2.070,P=0.071).The3-year relapse-free survival(RFS) was 49.2% and70.6%,respectively(HR=2.275,P=0.040).
文摘Objective To find out the distributed characteristics of KIR2DL1 alleles frequencies and the recognition HLAC ligand in the Chinese Han population.Methods The111 patients and 116 donors from CMDP were performed the KIR2DL1 high-resoluction typing and KIR genotyping using sequence-based testing(SBT)and PCR-SSP methods.Results A total of
文摘Objective To explore the influence of the killer cell immunoglobulin like receptor(KIR)gene polymorphism on cytomegalovirus(CMV)infection and pathogenesis after hematopoietic stem cell transplantation(HSCT)
文摘Objective To evaluate the efficacy of auto-HSCT and allo-HSCT in the treatment of high risk peripheral T cell lymphoma(PTCL).Methods From July 2007 to July 2014,60 cases of high risk PTCL were analyzed retrospectively.Results All 60 patients were at high risk group(carried with IPI≥3),with a median age of
文摘Objective To evaluate the prognostic significance of minimal residual disease(MRD)monitoring by 10-color flow cytometry in multiple myeloma(MM)patients after treatment.Methods 150 patients with MM who were admitted to the First Affiliated Hospital of Soochow University from July 2015 to July 2017 were retrospectively analyzed.
文摘Objective To investigate EVI1 expression and its associated clinical and cytogenetic characteristics in 447acute myeloid leukemia(AML)patients.Methods EVI1expressions were measured in 447 AML cases from Jan.2007 to Apr.2015 to couple with clinical。
文摘Objective By analyzing the risk factors for occurrence of differentiation syndrome(DS)during induction therapy in newly-diagnosed acute promyelocytic leukemia(APL)patients,a prediction nomogram for DS was established and the accuracy of this nomogram was validated.Methods The modeling group was made up of 130classical APL patients during the period of 1st。
