Effects of westward shoaling pycnocline on characteristics and energetics of internal solitary wave in the Luzon Strait by numerical simulations

An internal gravity wave model was employed to simulate the generation of internal solitary waves(ISWs)over a sill by tidal flows.A westward shoaling pycnocline parameterization scheme derived from a three-parameter model was adopted,and then 14 numerical experiments were designed to investigate the influence of the pycnocline thickness,density difference across the pycnocline,westward shoaling isopycnal slope angle and pycnocline depth on the ISWs.When the pycnocline thickness on both sides of the sill increases,the total barotropic kinetic energy,total baroclinic energy and ratio of baroclinic kinetic energy(KE)to available potential energy(APE)decrease,whilst the depth of isopycnal undergoing maximum displacement and ratio of baroclinic energy to barotropic energy increase.When the density difference on both sides of the sill decreases synchronously,the total barotropic kinetic energy,ratio of baroclinic energy to barotropic energy and total baroclinic energy decrease,whilst the depth of isopycnal undergoing maximum displacement increases.When the westward shoaling isopycnal slope angle increases,the total baroclinic energy increases whilst the depth of turning point almost remains unchanged.When the depth of westward shoaling pycnocline on both sides of the sill reduces,the ratio of baroclinic energy to barotropic energy and total baroclinic energy decrease,whilst the total barotropic kinetic energy and ratio of KE to APE increase.When one of the above four different influencing factors was increased by 10%while the other factors keep unchanged,the amplitude of the leading soliton in ISW Packet A was decreased by 2.80%,7.47%,3.21%and 6.42%respectively.The density difference across the pycnocline and the pycnocline depth are the two most important factors in affecting the characteristics and energetics of ISWs.

Aeromonas sobria regulates proinflammatory immune response in mouse macrophages via activating the MAPK,AKT,and NF-κB pathways

Aeromonas sobria,a Gram-negative bacterium that can colonize both humans and animals,is found in a variety of environments,including water,seafood,meat,and vegetables(Cahill,1990;Galindo et al.,2004;Song et al,2019).Aeromonas spp.are conditionally pathogenic bacteria in aquaculture,which can rapidly proliferate,causing disease and even death in fish,especially when the environment is degraded(Neamat-Allah et al,2020,2021a,2021b).In developing countries,Aeromonas spp.have been associated with a wide spectrum of infections in humans,including gastroen-teritis,wound infections,septicemia,and lung infections(San Joaquin and Pickett,1988;Wang et al,2009;Su et al,2013).Infections caused by Aeromonas spp.are usually more severe in immunocompromised individuals(Miyamoto et al,2017).