Two new terpenoids from fruits of Ziziphus jujuba

One new ceanothane-type triterpene and one new sesquiterpene, together with two known triterpenes were isolated from the fruits of Ziziphusjujuba Mill. （Rhamnaceae）. Based on the spectral analyses, the structures of two new compounds were elucidated as 2α-aldehydo-A（1）-norlup-20（29）-en-27,28-dioic acid （zizyberanal acid） （1）, and zizyberanone （2）. While the two known triterpenes were identified as zizyberanalic acid （3） and ursolic acid （4）.

Trifolirhizin induces autophagy-dependent apoptosis in colon cancer via AMPK/mTOR signaling

Dear Editor,Colorectal cancer(CRC)is one of the most frequent diseases with high mortality around the world.Conventional treatments of CRC remain unsatisfactory due to the increasing recurrence rate and adverse reactions including neutropenia,drug resistance,etc.Recently,autophagy has been shown to be involved in regulating cancer development and progression by regulating apoptosis through pro-apoptosis proteins including caspases,in addition to being a potential target for cancer therapeutic intervention.1 Trifolirhizin(Supplementary Fig.S1a)is a natural flavonoid glycosides isolated from Sophora flavescens as well as a bioactive constituent of Xian-Lian-Ke-Li,a commercial traditional Chinese medicine for the cancer prevention.Numerous evidence manifested that trifolirhizin inhibited proliferative activity in melanoma B16 cell,lung cancer H23 cell,human ovarian A2780 cell,and human gastric cancer cell MKN45.2 However,its pharmacological effect and mechanism on CRC remain elusive.Herein,we evaluated the effect of trifolirhizin on autophagy and apoptosis on CRC as well as its related mechanisms,in order to provide evidence to develop a potential agent with less adverse effect in treating CRC.

Synthetic studies on the construction of 7-O-methylquercetin through regioselective protection and alkylation of quercetin

在从在在四个步骤的36%产量的橡黄素的 7-O-methylquercetin 的构造的合成研究被报导，在另一方面，这策略作为溶剂用 dephenyl 醚与 dichlorodiphenylmethane 一方面依靠儿茶酚组的选择保护在有本甲基溴化物的3氢氧根组的选择保护上，这二个不同保护组能在一样的加氢下面被移开。