[Objectives]To explore the effects of injection of oregano oil submicron emulsion on lipopolysaccharide-induced pneumonia in rats.[Methods]Rats induced by lipopolysaccharide were used as animal models of acute pneumon...[Objectives]To explore the effects of injection of oregano oil submicron emulsion on lipopolysaccharide-induced pneumonia in rats.[Methods]Rats induced by lipopolysaccharide were used as animal models of acute pneumonia.The experiment was divided into blank group,model group,administration group and positive drug control group.The morphology of lung tissue and the changes of cells and inflammatory factors in each group were observed,and the anti-inflammatory effects of injection of oregano oil submicron emulsion.[Results]The injection of oregano oil submicron emulsion can improve the pathological injury of rat lung tissue,inhibit the release of IL-6,IL-10,TNF-αcytokines induced by lipopolysaccharide,and significantly reduce the value of CRP.[Conclusions]Oregano oil submicron emulsion has a certain therapeutic effect on lipopolysaccharide-induced pneumonia in rats,and its mechanism may be related to reducing the release of cytoinflammatory factor IL-6,IL-10,and TNF-αand alleviating the injury to tissues and organs.展开更多
基金Supported by National Natural Science Foundation of China(81860771)Science and Technology Project of the Education Department of Jiangxi Province(GJJ201219,GJJ170722)+2 种基金Students Innovative Entrepreneurial Training Plan Program of Jiangxi University of Traditional Chinese Medicine(202010412006,202010412143)Program of Key Discipline Training of Young Teachers of Jiangxi University of Traditional Chinese Medicine(2017jzzdxk001)Scientific Research Foundation of Jiangxi University of Traditional Chinese Medicine(2018WBZR011).
文摘[Objectives]To explore the effects of injection of oregano oil submicron emulsion on lipopolysaccharide-induced pneumonia in rats.[Methods]Rats induced by lipopolysaccharide were used as animal models of acute pneumonia.The experiment was divided into blank group,model group,administration group and positive drug control group.The morphology of lung tissue and the changes of cells and inflammatory factors in each group were observed,and the anti-inflammatory effects of injection of oregano oil submicron emulsion.[Results]The injection of oregano oil submicron emulsion can improve the pathological injury of rat lung tissue,inhibit the release of IL-6,IL-10,TNF-αcytokines induced by lipopolysaccharide,and significantly reduce the value of CRP.[Conclusions]Oregano oil submicron emulsion has a certain therapeutic effect on lipopolysaccharide-induced pneumonia in rats,and its mechanism may be related to reducing the release of cytoinflammatory factor IL-6,IL-10,and TNF-αand alleviating the injury to tissues and organs.
