期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
Identifying the geographical origin and processing technology of Moyao(Myrrh)on the basis of near-infrared spectroscopy combined with chemometrics
1
作者 XU Ningning YAN Ganming +4 位作者 XU Fengjie DENG Linfeng QIAO Xinjiang LU Changzheng CHENG Shaomin 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2024年第3期505-514,共10页
OBJECTIVE:To evaluate the quality of Moyao(Myrrh)in the identification of the geographical origin and processing of the products.METHODS:Raw Moyao(Myrrh)and two kinds of Moyao(Myrrh)processed with vinegar from three c... OBJECTIVE:To evaluate the quality of Moyao(Myrrh)in the identification of the geographical origin and processing of the products.METHODS:Raw Moyao(Myrrh)and two kinds of Moyao(Myrrh)processed with vinegar from three countries were identified using near-infrared(NIR)spectroscopy combined with chemometric techniques.Principal component analysis(PCA)was used to reduce the dimensionality of the data and visualize the clustering of samples from different categories.A classical chemometric algorithm(PLS-DA)and two machine learning algorithms[K-nearest neighbor(KNN)and support vector machine]were used to conduct a classification analysis of the near-infrared spectra of the Moyao(Myrrh)samples,and their discriminative performance was evaluated.RESULTS:Based on the accuracy,precision,recall rate,and F1 value in each model,the results showed that the classical chemometric algorithm and the machine learning algorithm obtained positive results.In all of the chemometric analyses,the NIR spectrum of Moyao(Myrrh)preprocessed by standard normal variation or Multivariate scattering correction combined with KNN achieved the highest accuracy in identifying the geographical origins,and the accuracy of identifying the processing technology established by the KNN method after first-order derivative pretreatment was the best.The best accuracy of geographical origin discrimination and processing technology discrimination were 0.9853 and 0.9706 respectively.CONCLUSIONS:NIR spectroscopy combined with chemometric technology can be an important tool for tracking the origin and processing technology of Moyao(Myrrh)and can also provide a reference for evaluations of its quality and the clinical use. 展开更多
关键词 Moyao(Myrrh) near-infrared spectroscopy geographical origin processing technology
原文传递
Design,synthesis and SAR study of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors
2
作者 Dandan Liu Huan Ge +6 位作者 Fangling Xu Yufang Xu Wenjun Liu Honglin Li Lili Zhu Yanyan Diao Zhenjiang Zhao 《Chinese Chemical Letters》 SCIE CAS CSCD 2022年第6期2969-2974,共6页
The abnormal activation of JAK2 kinase is closely related to the occurrence and progression of myeloproliferative neoplasms(MPNs).At present,there is still an obvious unmet medical need for selective JAK2 inhibitors i... The abnormal activation of JAK2 kinase is closely related to the occurrence and progression of myeloproliferative neoplasms(MPNs).At present,there is still an obvious unmet medical need for selective JAK2 inhibitors in clinic.In this paper,a class of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors was obtained by combining drug design,synthesis and structure-activity relationship studies based on the previously identified lead Crizotinib.Among them,21 b exhibited high inhibitory activity against JAK2 with an IC_(50)of 9 nmol/L,moreover,it showed 276-and 184-fold selectivity over JAK1 and JAK3,respectively.Besides,21 b had a significant antiproliferative activity against HEL cells,and also inhibited the phosphorylation of JAK2 and its down-stream signaling pathway.These results indicated that2-aminopyridine compound 21 b had the potential to be developed as a selective JAK2 inhibitor for further study. 展开更多
关键词 JAK2 SELECTIVITY INHIBITORS Cancer Structure-activity relationships
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部