Polypeptides are one kind of promising biodegradable and biocompatible biomedical polymers with the structural units of various a-amino acids.Polypeptides were first polymerized by the ring-opening polymerization(ROP)...Polypeptides are one kind of promising biodegradable and biocompatible biomedical polymers with the structural units of various a-amino acids.Polypeptides were first polymerized by the ring-opening polymerization(ROP)of α-amino acid N-carboxyanhydrides(NCAs)by Leuchs and Hermann in 1906.In the past decades,several effective strategies,including the selection of initiators,the adjustment of reaction conditions,and the introduction of catalysts,have been reported to improve the controllability of the ROP of various a-amino acid NCAs to synthesize different polypeptides with precise chemical structures and low polydispersity indexes.In this Review,the strategies,mechanisms,challenges,and opportunities for controlled synthesis of polypeptides by the ROP of differentα-amino acid NCAs have been declared.展开更多
基金the financial support from the National Natural Science Foundation of China(Nos.51973216,51873207,51803006,51833010,51673190 and 51520105004)the Science and Technology Development Program of Jilin Province(No.20190201068JC)+2 种基金the National Key Research and Development Program of China(No.2016YFC1100701)the Youth Talents Promotion Project of Jilin Province(No.181909)the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2019005)。
文摘Polypeptides are one kind of promising biodegradable and biocompatible biomedical polymers with the structural units of various a-amino acids.Polypeptides were first polymerized by the ring-opening polymerization(ROP)of α-amino acid N-carboxyanhydrides(NCAs)by Leuchs and Hermann in 1906.In the past decades,several effective strategies,including the selection of initiators,the adjustment of reaction conditions,and the introduction of catalysts,have been reported to improve the controllability of the ROP of various a-amino acid NCAs to synthesize different polypeptides with precise chemical structures and low polydispersity indexes.In this Review,the strategies,mechanisms,challenges,and opportunities for controlled synthesis of polypeptides by the ROP of differentα-amino acid NCAs have been declared.
