Emerging data indicate that the nervous system plays an important role in carcinogenesis. However, more studies are required to help further elucidate the mechanisms involved in the neural regulation of carcinogenesis...Emerging data indicate that the nervous system plays an important role in carcinogenesis. However, more studies are required to help further elucidate the mechanisms involved in the neural regulation of carcinogenesis. Some recent findings describing the neural regulatory mechanisms of action in prostate cancer, pancreatic cancer and hepatocellular carcinoma are discussed, with a focus on the sympathetic, parasympathetic, and sensory neuronal elements of the nervous system. Norepinephrine, which is released by the sympathetic nervous system and binds to the beta-adrenergic receptor, regulates cellular responses in both normal and tumor cells. It has also been shown that the destruction of sensory neurons can prevent or at least slow pancreatic cancer. Cortisol, the main stress hormone, is also discussed and how it could potentially be involved in hepatocellular carcinoma development. The importance of studying other signaling molecules in the nervous system, such as oxytocin and its receptor, the oxytocin receptor, and how they might be involved in carcinogenesis when aberrantly expressed is highlighted. This is an area of study which clearly needs further investigation. A clearer understanding of the detailed mechanisms of how the nervous system is involved in carcinogenesis could potentially aid in the identification of novel biomarkers and development of novel preventative and therapeutic strategies in various cancers.展开更多
Dietary oversupply of triglycerides represent the hallmark of obesity and connected complications in the liver such as non-alcoholic fatty liver disease and non-alcoholic steatohepatitis,which eventually progress to c...Dietary oversupply of triglycerides represent the hallmark of obesity and connected complications in the liver such as non-alcoholic fatty liver disease and non-alcoholic steatohepatitis,which eventually progress to cirrhosis and hepatocellular carcinoma.Monoacylglycerol lipase is the last enzymatic step in the hydrolysis of triglycerides,generating glycerol and fatty acids(FAs),which are signaling precursors in physiology and disease.Notably,monoacylglycerol lipase(MGL)also hydrolyzes 2-arachidonoylglycerol,which is a potent ligand within the endocannabinoid system,into arachidonic acid-a precursor for prostaglandin synthesis;thus representing a pivotal substrates provider in multiple organs for several intersecting biological pathways ranging from FA metabolism to inflammation,pain and appetite.MGL inhibition has been shown protective in limiting several liver diseases as FAs may drive hepatocyte injury,fibrogenesis and de-activate immune cells,however the complexity of MGL network system still needs further and deeper understanding.The present review will focus on MGL function and FA partitioning in the horizons of liver disease.展开更多
基金Supported by the National Cancer Institute of United States,No.U54CA221704
文摘Emerging data indicate that the nervous system plays an important role in carcinogenesis. However, more studies are required to help further elucidate the mechanisms involved in the neural regulation of carcinogenesis. Some recent findings describing the neural regulatory mechanisms of action in prostate cancer, pancreatic cancer and hepatocellular carcinoma are discussed, with a focus on the sympathetic, parasympathetic, and sensory neuronal elements of the nervous system. Norepinephrine, which is released by the sympathetic nervous system and binds to the beta-adrenergic receptor, regulates cellular responses in both normal and tumor cells. It has also been shown that the destruction of sensory neurons can prevent or at least slow pancreatic cancer. Cortisol, the main stress hormone, is also discussed and how it could potentially be involved in hepatocellular carcinoma development. The importance of studying other signaling molecules in the nervous system, such as oxytocin and its receptor, the oxytocin receptor, and how they might be involved in carcinogenesis when aberrantly expressed is highlighted. This is an area of study which clearly needs further investigation. A clearer understanding of the detailed mechanisms of how the nervous system is involved in carcinogenesis could potentially aid in the identification of novel biomarkers and development of novel preventative and therapeutic strategies in various cancers.
文摘Dietary oversupply of triglycerides represent the hallmark of obesity and connected complications in the liver such as non-alcoholic fatty liver disease and non-alcoholic steatohepatitis,which eventually progress to cirrhosis and hepatocellular carcinoma.Monoacylglycerol lipase is the last enzymatic step in the hydrolysis of triglycerides,generating glycerol and fatty acids(FAs),which are signaling precursors in physiology and disease.Notably,monoacylglycerol lipase(MGL)also hydrolyzes 2-arachidonoylglycerol,which is a potent ligand within the endocannabinoid system,into arachidonic acid-a precursor for prostaglandin synthesis;thus representing a pivotal substrates provider in multiple organs for several intersecting biological pathways ranging from FA metabolism to inflammation,pain and appetite.MGL inhibition has been shown protective in limiting several liver diseases as FAs may drive hepatocyte injury,fibrogenesis and de-activate immune cells,however the complexity of MGL network system still needs further and deeper understanding.The present review will focus on MGL function and FA partitioning in the horizons of liver disease.
