Since December 2019,the outbreak of infection caused by 2019 novel coronavirus(2019-nCoV)has become a major public health emergency worldwide.Approximately 40%of the confirmed cases of 2019-nCoV infection(judged by po...Since December 2019,the outbreak of infection caused by 2019 novel coronavirus(2019-nCoV)has become a major public health emergency worldwide.Approximately 40%of the confirmed cases of 2019-nCoV infection(judged by positivity of viral RNA testing)were initially asymptomatic but later developed overt clinical symptoms of coronavirus disease-2019(COVID-19).[1]A presumed asymptomatic carrier of 2019-nCoV was also reported.[2]But her infection of 2019-nCoV was not fully confirmed.As far as we know,confirmed 2019-nCoV carriers but without overt clinical symptoms have been not yet reported.展开更多
Dear Editor,In January 2020,a widespread outbreak of coronavirus disease 2019(COVID-19)occurred after the beginning of the largest annual migration in China,which is known as the Spring Festival migration.Starting in ...Dear Editor,In January 2020,a widespread outbreak of coronavirus disease 2019(COVID-19)occurred after the beginning of the largest annual migration in China,which is known as the Spring Festival migration.Starting in January 20,2020,the Chinese government took a series of unprecedented measures to contain the spread of COVID-19.Because of the role of Wuhan as a central transportation hub.展开更多
Dear editor,The 2019 novel coronavirus(later renamed as SARS-CoV-2 in February 2020)infected over 12 million people globally by early July 2020,causing mild to severe COVID-19 in millions.Monitoring the levels of anti...Dear editor,The 2019 novel coronavirus(later renamed as SARS-CoV-2 in February 2020)infected over 12 million people globally by early July 2020,causing mild to severe COVID-19 in millions.Monitoring the levels of antibodies such as immunoglobin(Ig)G,M and A that are specific to SARS-CoV-2 and present in the blood provides not only an alternative method for diagnosing SARS-CoV-2 infection(including asymptomatic carriers),but also a simple way to monitor immune responses in convalescent patients or after vaccination.A high and persistent level of antibodies specific to SARS-CoV-2,especially those that can bind to and neutralize the virus,would be a strong indication that an immunized host could resist to SRAS-CoV-2 infection.Currently,there are no effective drugs to specifically prevent or cure SARS-CoV-2 infection;therefore,host immune responses and antibody-based therapeutics will continue to play important roles in combating and later preventing COVID-19.展开更多
基金This work was supported by grants from the Fundamental Research Funds for the Central Universities"Emergency response to new coronavirus infection scientific and technological project"(Nos.YD9110004001,YD9110002002)Anhui Provincial Department of Science and Technology,Anhui Provincial Health Commission Emergency Research Project"Epidemiological and clinical characteristics of new coronavirus pneumonia"(No.202004a07020002)。
文摘Since December 2019,the outbreak of infection caused by 2019 novel coronavirus(2019-nCoV)has become a major public health emergency worldwide.Approximately 40%of the confirmed cases of 2019-nCoV infection(judged by positivity of viral RNA testing)were initially asymptomatic but later developed overt clinical symptoms of coronavirus disease-2019(COVID-19).[1]A presumed asymptomatic carrier of 2019-nCoV was also reported.[2]But her infection of 2019-nCoV was not fully confirmed.As far as we know,confirmed 2019-nCoV carriers but without overt clinical symptoms have been not yet reported.
基金the Fundamental Research Funds for the Central Universities (YD9110004001 to JW, YD9110002002 to XY)Emergency Research Project of Novel Coronavirus Infection of Anhui Province (202004a07020002 to ZRL202004a07020004 to ZRL)。
文摘Dear Editor,In January 2020,a widespread outbreak of coronavirus disease 2019(COVID-19)occurred after the beginning of the largest annual migration in China,which is known as the Spring Festival migration.Starting in January 20,2020,the Chinese government took a series of unprecedented measures to contain the spread of COVID-19.Because of the role of Wuhan as a central transportation hub.
基金T.J.is supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29030104)National Natural Science Foundation of China(31870731 and U1732109)+3 种基金the Fundamental Research Funds for the Central Universities(WK2070000108)a COVID-19 special task grant supported by Chinese Academy of Sciences Clinical Research Hospital(Hefei)with Grant No.YD2070002017M.H.is supported by the new medical science fund of University of Science and Technology of China(WK2070000130)J.W.and X.Y.are supported by the Fundamental Research Funds for the Central Universities with Grant Nos.YD9110004001 and YD9110002002,respectively.
文摘Dear editor,The 2019 novel coronavirus(later renamed as SARS-CoV-2 in February 2020)infected over 12 million people globally by early July 2020,causing mild to severe COVID-19 in millions.Monitoring the levels of antibodies such as immunoglobin(Ig)G,M and A that are specific to SARS-CoV-2 and present in the blood provides not only an alternative method for diagnosing SARS-CoV-2 infection(including asymptomatic carriers),but also a simple way to monitor immune responses in convalescent patients or after vaccination.A high and persistent level of antibodies specific to SARS-CoV-2,especially those that can bind to and neutralize the virus,would be a strong indication that an immunized host could resist to SRAS-CoV-2 infection.Currently,there are no effective drugs to specifically prevent or cure SARS-CoV-2 infection;therefore,host immune responses and antibody-based therapeutics will continue to play important roles in combating and later preventing COVID-19.
