A new impurity was detected during high performance liquid chromatographic （HPLC） analysis of eslicarbazepine acetate active pharmaceutical ingredient. The structure of unknown impurity was postulated based on liqui...A new impurity was detected during high performance liquid chromatographic （HPLC） analysis of eslicarbazepine acetate active pharmaceutical ingredient. The structure of unknown impurity was postulated based on liquid chromatography mass spectrometry using electrospray ionization and ion trap analyzer （LC/ESI-IT/MS） analysis. Proposed structure of impurity was unambiguously confirmed by synthesis followed by characterization using 1H, 13C nuclear magnetic resonance spectrometry （NMR）, 1H-1H correlation spectro-scopy （COSY） and infrared spectroscopy （IR）. Based on the spectroscopic and spectrometric data, unknown impurity was characterized as 5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl propionate.展开更多
A highly sensitive, selective, and precise ultra-performance liquid chromatography tandem mass spectrometry method was developed and validated for simultaneous quantification of itraconazole and hydroxy itraconazole i...A highly sensitive, selective, and precise ultra-performance liquid chromatography tandem mass spectrometry method was developed and validated for simultaneous quantification of itraconazole and hydroxy itraconazole in human plasma by a single liquid-liquid extraction step. The precursor to product ion transitions of m/z 705.3/392.3, m/z 721.2/408.3 and m/z 708.2/435.4 were used to detect and quantify itraconazole, hydroxy itraconazole and itraconazole-d3 respectively. The lower limit of quantitation was found to be 0.500 ng/mL for itraconazole and 1.00 ng/mL for hydroxy itraconazole. The mean recoveries for itraconazole and hydroxy itraconazole were found to be 100.045% and 100.021%, respectively. This developed method with a chromatographic run time of 2.0 min was successfully applied to a bioequivalence study of 100 mg itraconazole capsule.展开更多
Ricinine(3-cyano-4-methoxy-N-methyl-2-pyridone)is an alkaloid present in leaves and seeds of castor plant i.e.Ricinus communis.It can cause vomiting,convulsions,hypotension,liver and kidney damage and several other co...Ricinine(3-cyano-4-methoxy-N-methyl-2-pyridone)is an alkaloid present in leaves and seeds of castor plant i.e.Ricinus communis.It can cause vomiting,convulsions,hypotension,liver and kidney damage and several other complications in human.Ricinine presents mainly in young plant and it is the only cyano-substituted pyridine compounds occurred naturally.Ricinine also found in some other plants such as Piper nigrum,Discocleidion rufescens,Aparisthmium cordatum and Nicotiana tabacum.Accidental and intended Ricinus communis intoxications in humans and animals have been known for centuries.In the present review,we summarize the information regarding its medicinal uses,pharmacological activities,analytical techniques and intended and unintended poisoning cases in humans and animals.This review will be beneficial for the researcher in the field of herbal medicine and other allied sciences.展开更多
Herbal plant materials have huge potential in the field of medicine,nutraceuticals,perfumery,beverages,fragrances,cosmetics and dyeing industry.Centella asiatica(L.)Urban(family:Apiaceae)(C.asiatica)is a very popular ...Herbal plant materials have huge potential in the field of medicine,nutraceuticals,perfumery,beverages,fragrances,cosmetics and dyeing industry.Centella asiatica(L.)Urban(family:Apiaceae)(C.asiatica)is a very popular medicinal herb in Sri Lanka,Madagascar,India and other parts of Asia.Gotu kola,Brahmi and Mandukparniin are the synonyms of C.asiatica which is mainly used for improving memory power.The pharmacological importance of C.asiatica is mainly because of triterpenes such as asiatic acid,asiaticoside,madecassoside and madecassic acid,etc.C.asiatica is mainly used for the treatment of mental fatigue,anxiety,epidermal wound,eczema,leprosy,asthma,psoriasis,ulcers and vein diseases.Asiaticoside is a pentacyclic triterpenoid saponin having anti-depression,anti-tumor,anti-inflammatory,antioxidant properties and further it also possesses wound healing,antiulcer and anti-hepatofibrotic activities.It improved cognitive impairment in diabetic condition because of the decreased oxidative stress.Quantification of asiaticoside in C.asiatica has been done by several methods which were mainly based on high performance liquid chromatography methods using different compositions of mobile phase sand detection systems.In these days scientists are trying to discover novel medicine from natural sources for the development of better drugs.In this review we have collected information of asiaticoside in respect to its medicinal values,pharmacological activities,extraction,isolation,and other analytical aspects.So the present review will be supportive to the scientists who are trying to develop some novel medicines from asiaticoside for the better health prospects.展开更多
文摘A new impurity was detected during high performance liquid chromatographic （HPLC） analysis of eslicarbazepine acetate active pharmaceutical ingredient. The structure of unknown impurity was postulated based on liquid chromatography mass spectrometry using electrospray ionization and ion trap analyzer （LC/ESI-IT/MS） analysis. Proposed structure of impurity was unambiguously confirmed by synthesis followed by characterization using 1H, 13C nuclear magnetic resonance spectrometry （NMR）, 1H-1H correlation spectro-scopy （COSY） and infrared spectroscopy （IR）. Based on the spectroscopic and spectrometric data, unknown impurity was characterized as 5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl propionate.
文摘A highly sensitive, selective, and precise ultra-performance liquid chromatography tandem mass spectrometry method was developed and validated for simultaneous quantification of itraconazole and hydroxy itraconazole in human plasma by a single liquid-liquid extraction step. The precursor to product ion transitions of m/z 705.3/392.3, m/z 721.2/408.3 and m/z 708.2/435.4 were used to detect and quantify itraconazole, hydroxy itraconazole and itraconazole-d3 respectively. The lower limit of quantitation was found to be 0.500 ng/mL for itraconazole and 1.00 ng/mL for hydroxy itraconazole. The mean recoveries for itraconazole and hydroxy itraconazole were found to be 100.045% and 100.021%, respectively. This developed method with a chromatographic run time of 2.0 min was successfully applied to a bioequivalence study of 100 mg itraconazole capsule.
基金Supported by University Grant Commision,New Delhi,India with grant No.:IT/DEV/08-09/3252/L.
文摘Ricinine(3-cyano-4-methoxy-N-methyl-2-pyridone)is an alkaloid present in leaves and seeds of castor plant i.e.Ricinus communis.It can cause vomiting,convulsions,hypotension,liver and kidney damage and several other complications in human.Ricinine presents mainly in young plant and it is the only cyano-substituted pyridine compounds occurred naturally.Ricinine also found in some other plants such as Piper nigrum,Discocleidion rufescens,Aparisthmium cordatum and Nicotiana tabacum.Accidental and intended Ricinus communis intoxications in humans and animals have been known for centuries.In the present review,we summarize the information regarding its medicinal uses,pharmacological activities,analytical techniques and intended and unintended poisoning cases in humans and animals.This review will be beneficial for the researcher in the field of herbal medicine and other allied sciences.
文摘Herbal plant materials have huge potential in the field of medicine,nutraceuticals,perfumery,beverages,fragrances,cosmetics and dyeing industry.Centella asiatica(L.)Urban(family:Apiaceae)(C.asiatica)is a very popular medicinal herb in Sri Lanka,Madagascar,India and other parts of Asia.Gotu kola,Brahmi and Mandukparniin are the synonyms of C.asiatica which is mainly used for improving memory power.The pharmacological importance of C.asiatica is mainly because of triterpenes such as asiatic acid,asiaticoside,madecassoside and madecassic acid,etc.C.asiatica is mainly used for the treatment of mental fatigue,anxiety,epidermal wound,eczema,leprosy,asthma,psoriasis,ulcers and vein diseases.Asiaticoside is a pentacyclic triterpenoid saponin having anti-depression,anti-tumor,anti-inflammatory,antioxidant properties and further it also possesses wound healing,antiulcer and anti-hepatofibrotic activities.It improved cognitive impairment in diabetic condition because of the decreased oxidative stress.Quantification of asiaticoside in C.asiatica has been done by several methods which were mainly based on high performance liquid chromatography methods using different compositions of mobile phase sand detection systems.In these days scientists are trying to discover novel medicine from natural sources for the development of better drugs.In this review we have collected information of asiaticoside in respect to its medicinal values,pharmacological activities,extraction,isolation,and other analytical aspects.So the present review will be supportive to the scientists who are trying to develop some novel medicines from asiaticoside for the better health prospects.
