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Numerically investigation of particle distribution in industrial-scale DTB crystallizer based on CFD
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作者 Jinju Ma Weiyu Wang +4 位作者 Wei Huang Wei Liu Xinding Yao Tao Li Baozeng Ren 《Particuology》 SCIE EI CAS CSCD 2024年第10期186-202,共17页
The suspension state of crystals in the crystallizer is one of the important indicators for evaluating the adaptability of the crystallizer.This study adopted the Euler-Eulerian two-fluid model to simulate and analyze... The suspension state of crystals in the crystallizer is one of the important indicators for evaluating the adaptability of the crystallizer.This study adopted the Euler-Eulerian two-fluid model to simulate and analyze the fluid motion of solid-liquid two-phase flow in the industrial-grade DTB crystallization kettle,as well as the phase suspension distribution of crystal particles.The main influencing factors investigated are:the heat transfer effect,the height of the bottom of the crystallizer,the number and position of the stirring paddle,crystal size and crystal volume fraction.Based on the research of Euler-Eulerian method to simulate fluids,the Euler-Lagrangian method was further used to simulate the motion state of particle phases with different particle sizes in the crystallizer.It was found that the designed DTB crystallizer has good recycle mixing effect.The particles can be mixed evenly during the operation,which can fully realize the solid-liquid mixing and suspension effect of the drug under study. 展开更多
关键词 Draff tube baffle(DTB)crystallizer Two-fluid model Numerical simulation Turbulence modelling
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