Objective:To determine the antibacterial efficacy and brine shrimp toxicity of extracts(hexane,dichloromethane,ethyl acetate,methanol and water)obtained from the bark of Schleichera oleosa.Methods:The powdered bark sa...Objective:To determine the antibacterial efficacy and brine shrimp toxicity of extracts(hexane,dichloromethane,ethyl acetate,methanol and water)obtained from the bark of Schleichera oleosa.Methods:The powdered bark sample was Soxhlet extracted sequentially in hexanes,dichloromethane,ethyl acetate,methanol and water.Antibacterial evaluation was carried out by following the agar diffusion method and amoxicillin disc was used as a reference.Slightly modified Meyer’s method was used to determine the toxicity of the extracts in brine shrimps.Results:Among the nine bacterial strains tested,the methanolic and aqueous extracts showed promising antibacterial efficacy against Serratia marcescens,Escherarichia coli,Bacillus subtilis and Micrococcus luteus.None of the extracts were found significantly toxic to brine shrimps.Conclusions:Strong antibacterial activity and low brine shrimp toxicity of methanolic and aqueous extracts can provide new antibacterial compounds.展开更多
Alzheimer’s disease(AD),a neurodegenerative disorder,has been determined as an outcome of genetic as well as behavioral conditions.The complete understanding of its generation and progress is yet to be understood.How...Alzheimer’s disease(AD),a neurodegenerative disorder,has been determined as an outcome of genetic as well as behavioral conditions.The complete understanding of its generation and progress is yet to be understood.However,there has been a significant progress in the diagnosis and identification of the associated risk factors of AD.Several of the risk factors were found connected with cholesterol.Scientists are mainly focusing on the reduction of amyloid β and stabilization of tau protein towards the development of its drugs.To modulate amyloid β,the key components of cholesterol metabolism have been attractive targets and the enzymes involved in the phosphorylation of tau have been tried to stabilize tau protein.This review article briefly highlights the symptoms,risk factors,and drug targets of AD.展开更多
基金Supported by Nepal Academy of Science and Technology.
文摘Objective:To determine the antibacterial efficacy and brine shrimp toxicity of extracts(hexane,dichloromethane,ethyl acetate,methanol and water)obtained from the bark of Schleichera oleosa.Methods:The powdered bark sample was Soxhlet extracted sequentially in hexanes,dichloromethane,ethyl acetate,methanol and water.Antibacterial evaluation was carried out by following the agar diffusion method and amoxicillin disc was used as a reference.Slightly modified Meyer’s method was used to determine the toxicity of the extracts in brine shrimps.Results:Among the nine bacterial strains tested,the methanolic and aqueous extracts showed promising antibacterial efficacy against Serratia marcescens,Escherarichia coli,Bacillus subtilis and Micrococcus luteus.None of the extracts were found significantly toxic to brine shrimps.Conclusions:Strong antibacterial activity and low brine shrimp toxicity of methanolic and aqueous extracts can provide new antibacterial compounds.
文摘Alzheimer’s disease(AD),a neurodegenerative disorder,has been determined as an outcome of genetic as well as behavioral conditions.The complete understanding of its generation and progress is yet to be understood.However,there has been a significant progress in the diagnosis and identification of the associated risk factors of AD.Several of the risk factors were found connected with cholesterol.Scientists are mainly focusing on the reduction of amyloid β and stabilization of tau protein towards the development of its drugs.To modulate amyloid β,the key components of cholesterol metabolism have been attractive targets and the enzymes involved in the phosphorylation of tau have been tried to stabilize tau protein.This review article briefly highlights the symptoms,risk factors,and drug targets of AD.
