Objective：To observe the effects of moxibustion pretreatment on Glutathione Peroxidase（GSH-Px）,Superoxide Dismutase（SOD）,and Malondialchehyche（MDA）in gastric mucosa of rats with stress ulcer,and to investigate ...Objective：To observe the effects of moxibustion pretreatment on Glutathione Peroxidase（GSH-Px）,Superoxide Dismutase（SOD）,and Malondialchehyche（MDA）in gastric mucosa of rats with stress ulcer,and to investigate the mechanism of moxibustion pretreatment preventing the oxidized injury of gastric mucosa.Methods：Forty-eight healthy SD rats were randomly allocated into 4 groups,namely control group,model group,acupoint moxibustion group,and non-acupoint moxibustion group.The ulcer model was developed by restraint and water immersion stress,Ulcer index（UI）was calculated with Guth method,and the contents of GSH-Px,and MDA and SOD activity in the gastric tissues were measured with chromatometry method.Results：Compared those in the model group and nonacupoint moxibustion group,moxibustion at Zusanli（ST 36）could decrease the UI（P〈0.01）and MDA（P〈0.05）contents,and increase the activity of GSH-Px（P〈0.01）and SOD（P〈0.05）.Conclusion：Pretreatment of moxibustion at Zusanli（ST 36）could promote the recovery of gastric injury in rats induced by restraint and water immersion stress by enhancing the activity of GSH-Px and SOD,and lower MDA content.展开更多
基金National Basic Research Program of China(973Program,2009CB522904)National Natural Science Foundation of China(30973802)+1 种基金Key Project of the Hu'nan Department of Education(08A048)Hu'nan Provincial Innovation Foundation for Postgraduates(CX2009B172)
文摘Objective：To observe the effects of moxibustion pretreatment on Glutathione Peroxidase（GSH-Px）,Superoxide Dismutase（SOD）,and Malondialchehyche（MDA）in gastric mucosa of rats with stress ulcer,and to investigate the mechanism of moxibustion pretreatment preventing the oxidized injury of gastric mucosa.Methods：Forty-eight healthy SD rats were randomly allocated into 4 groups,namely control group,model group,acupoint moxibustion group,and non-acupoint moxibustion group.The ulcer model was developed by restraint and water immersion stress,Ulcer index（UI）was calculated with Guth method,and the contents of GSH-Px,and MDA and SOD activity in the gastric tissues were measured with chromatometry method.Results：Compared those in the model group and nonacupoint moxibustion group,moxibustion at Zusanli（ST 36）could decrease the UI（P〈0.01）and MDA（P〈0.05）contents,and increase the activity of GSH-Px（P〈0.01）and SOD（P〈0.05）.Conclusion：Pretreatment of moxibustion at Zusanli（ST 36）could promote the recovery of gastric injury in rats induced by restraint and water immersion stress by enhancing the activity of GSH-Px and SOD,and lower MDA content.
