We present the design and synthesis of polyoxazole-based macrocycles containing a phosphonate group.A reliable route was established that allows for convenient and versatile incorporation of various phosphonate functi...We present the design and synthesis of polyoxazole-based macrocycles containing a phosphonate group.A reliable route was established that allows for convenient and versatile incorporation of various phosphonate functionalities such as phosphonate ester,acid,and salt at the macrocyclic ring periphery.Such unprecedented macrocyclic compounds are anticipated to be appealing candidates as telomerase inhibitors.展开更多
基金the National Natural Science Foundation of China(No.21272225)the Key Lab of Synthetic Chemistry of Natural Substances,Shanghai Institute of Organic Chemistry,is acknowledged.
文摘We present the design and synthesis of polyoxazole-based macrocycles containing a phosphonate group.A reliable route was established that allows for convenient and versatile incorporation of various phosphonate functionalities such as phosphonate ester,acid,and salt at the macrocyclic ring periphery.Such unprecedented macrocyclic compounds are anticipated to be appealing candidates as telomerase inhibitors.
