Most biological tissues are supple and elastic,while current electronic devices fabricated by semiconductors and metals are usually stiff and brittle. As a result,implanted electronic devices can irritate and damage s...Most biological tissues are supple and elastic,while current electronic devices fabricated by semiconductors and metals are usually stiff and brittle. As a result,implanted electronic devices can irritate and damage surrounding tissues,causing immune reaction and scarring. In this work,we develop stretchable microelectrode arrays,with the development of a novel soft lithography technology,which are designed and fabricated with a polymer/stretchable metal/polymer sandwich structure. With the great deformability of stretch,compression,bend and twisting,while preserving electrical property,this technology overcomes the fundamental mismatch of mechanical properties between biological tissues and electronic devices,and provides highly-compliant,conformal and stretchable bio-electronic interfaces. Here we also describe the following three applications of the stretchable electrode arrays:a. monitoring intracranial electroencephalography (EEG);b. stimulating peripheral nerves to drive muscles;c. monitoring epicardial electrocardiography (ECG). Stretchable microelectrode arrays create a promising field in biomedical applications for its better modulus match with biological tissues and robust mechanical and electrical properties. They allow for construction of electronic integrated circuits spread over on complex and dynamic curved surfaces,providing a much friendlier bio-electronic interface for diagnosis,treatment and intelligent bio-control.展开更多
Wearable technology,which can continuously and remotely monitor physiological and behavioral parameters by incorporated into clothing or worn as an accessory,introduces a new era for ubiquitous health care.With big da...Wearable technology,which can continuously and remotely monitor physiological and behavioral parameters by incorporated into clothing or worn as an accessory,introduces a new era for ubiquitous health care.With big data technology,wearable data can be analyzed to help long-term cardiovascular care.This review summarizes the recent developments of wearable technology related to cardiovascular care,highlighting the most common wearable devices and their accuracy.We also examined the application of these devices in cardiovascular healthcare,such as the early detection of arrhythmias,measuring blood pressure,and detecting prevalent diabetes.We provide an overview of the challenges that hinder the widespread application of wearable devices,such as inadequate device accuracy,data redundancy,concerns associated with data security,and lack of meaningful criteria,and offer potential solutions.Finally,the future research direction for cardiovascular care using wearable devices is discussed.展开更多
基金National Natural Science Foundation of China (No. 61102042)Youth Innovation Foundation of Chinese Academy of SciencesShenzhen"Peacock Plan"to Z.Y.
文摘Most biological tissues are supple and elastic,while current electronic devices fabricated by semiconductors and metals are usually stiff and brittle. As a result,implanted electronic devices can irritate and damage surrounding tissues,causing immune reaction and scarring. In this work,we develop stretchable microelectrode arrays,with the development of a novel soft lithography technology,which are designed and fabricated with a polymer/stretchable metal/polymer sandwich structure. With the great deformability of stretch,compression,bend and twisting,while preserving electrical property,this technology overcomes the fundamental mismatch of mechanical properties between biological tissues and electronic devices,and provides highly-compliant,conformal and stretchable bio-electronic interfaces. Here we also describe the following three applications of the stretchable electrode arrays:a. monitoring intracranial electroencephalography (EEG);b. stimulating peripheral nerves to drive muscles;c. monitoring epicardial electrocardiography (ECG). Stretchable microelectrode arrays create a promising field in biomedical applications for its better modulus match with biological tissues and robust mechanical and electrical properties. They allow for construction of electronic integrated circuits spread over on complex and dynamic curved surfaces,providing a much friendlier bio-electronic interface for diagnosis,treatment and intelligent bio-control.
基金National Natural Science Foundation of China(No.U1913210)in part by the Strategic Priority CAS Project(XDB38040200)in part by the Basic Research Project of Shenzhen(JCYJ20210324101206017)
文摘Wearable technology,which can continuously and remotely monitor physiological and behavioral parameters by incorporated into clothing or worn as an accessory,introduces a new era for ubiquitous health care.With big data technology,wearable data can be analyzed to help long-term cardiovascular care.This review summarizes the recent developments of wearable technology related to cardiovascular care,highlighting the most common wearable devices and their accuracy.We also examined the application of these devices in cardiovascular healthcare,such as the early detection of arrhythmias,measuring blood pressure,and detecting prevalent diabetes.We provide an overview of the challenges that hinder the widespread application of wearable devices,such as inadequate device accuracy,data redundancy,concerns associated with data security,and lack of meaningful criteria,and offer potential solutions.Finally,the future research direction for cardiovascular care using wearable devices is discussed.
