The accumulation of solubleβ-amyloid aggregates(sAβs)is one of the main culprits in Alzheimer’s disease(AD)progression,which can lead to synaptic dysfunction and subsequent neurodegeneration.Herein,we describe a na...The accumulation of solubleβ-amyloid aggregates(sAβs)is one of the main culprits in Alzheimer’s disease(AD)progression,which can lead to synaptic dysfunction and subsequent neurodegeneration.Herein,we describe a nanoscavenger with novel structure that can cross the blood–brain barrier(BBB),accurately collect neurotoxic sAβs,and facilitate amounts ofβ-amyloid(Aβ)clearance.展开更多
基金supported by the National Key Research and Development Programs of China(grant no.2018YFA0209700)the National Natural Science Foundation of China(NSFC+4 种基金grant nos.51673100 and 21620102005)the Fundamental Research Funds for the Central Universities(Nankai Universitygrant nos.ZB19100123 and ZB16008705)the Tianjin Natural Science Foundation(grant no.18JCQNJC03600)the China Postdoctoral Science Foundation(grant no.2019M660975).
文摘The accumulation of solubleβ-amyloid aggregates(sAβs)is one of the main culprits in Alzheimer’s disease(AD)progression,which can lead to synaptic dysfunction and subsequent neurodegeneration.Herein,we describe a nanoscavenger with novel structure that can cross the blood–brain barrier(BBB),accurately collect neurotoxic sAβs,and facilitate amounts ofβ-amyloid(Aβ)clearance.
