Metal-organic frameworks(MOFs)composed of functional metal ions/clusters and suitable bridging ligands are highly designable,which have shown excellent catalytic activity as nanozymes and are promising for antibacteri...Metal-organic frameworks(MOFs)composed of functional metal ions/clusters and suitable bridging ligands are highly designable,which have shown excellent catalytic activity as nanozymes and are promising for antibacterial therapy.Herein,twodimensional(2D)copper MOF nanosheets(Cu-MOF NSs)as effective antibacterial agents were prepared through a simple onestep method.The 2D Cu-MOF NSs displayed a peroxidase-like activity toward H_(2)O_(2)decomposition into highly cytotoxic hydroxyl radicals(·OH).Notably,the 2D morphology of Cu-MOF NSs provides a high density of Cu^(2+)/Cu^(+)surface active sites,which could efficiently oxidize the proteins and lipids on the bacterial surface and induce the death of bacteria.It is found that the as-prepared 2D Cu-MOF NSs exhibited antibacterial properties against Staphylococcus aureus(S.aureus)and could efficiently eradicate the biofilm of S.aureus.Up to 99.9%bacteria were killed at a Cu-MOF concentration of 4μg/m L.This study opens a new avenue for the design of MOF-based antibacterial agents to combat pathogenic bacterial infections.展开更多
Antioxidant collagen hydrolysates refers to the peptides mixture with antioxidant properties identified from hydrolyzed collagen.Due to its specific structural,biological and physicochemical properties,collagen hydrol...Antioxidant collagen hydrolysates refers to the peptides mixture with antioxidant properties identified from hydrolyzed collagen.Due to its specific structural,biological and physicochemical properties,collagen hydrolysates have been explored as a multifunctional antioxidant in the biomedical field.In this review,we summarize recent advances in antioxidant collagen hydrolysates development.Initially,the preparation process of antioxidant collagen hydrolysates is introduced,including the production and separation methods.Then the effects and the mechanisms of amino acid composition and collagen peptide structure on the antioxidant activity of collagen hydrolysates are reviewed.Finally,the applications of antioxidant collagen hydrolysates in biomedical domains are summarized,with critical discussions about the advantages,current limitations and challenges to be resolved in the future.展开更多
Immunotherapy brings new hope for tumor treatment by inducing immunogenic cell death(ICD)of tumor cells.However,insufficient immunogenicity and low immune response rate greatly limit antitumor immunity.Herein,by optim...Immunotherapy brings new hope for tumor treatment by inducing immunogenic cell death(ICD)of tumor cells.However,insufficient immunogenicity and low immune response rate greatly limit antitumor immunity.Herein,by optimizing the composition and morphology,the rational design of Janus nanoparticles composed of Fe_(3)O_(4) nanospheres and SiO_(2)nanorods was realized for enhanced cancer immunotherapy through amplified ICD.After glucose oxidase(GOx)was loaded by the Janus nanoparticles,the resultant M-FS-GOx consumes glucose at tumor sites to generate gluconic acid and hydrogen peroxide(H_(2)O_(2))for starvation therapy while the H_(2)O_(2)supply promotes the production of highly toxic·OH to achieve effective chemodynamic therapy(CDT).Under a 1064 nm light irradiation,the photothermal effect of M-FS-GOx enhances the enzyme activity of GOx for improved starvation therapy.Furthermore,both tumor-associated antigens released during the process of ICD and the intrinsic immunoadjuvant property of M-FS-GOx stimulate dendritic cell maturation to activate antitumor immune responses.This work provides a promising strategy for the construction of Janus nanoparticles to achieve enhanced cancer immunotherapy through combination therapy-amplified ICD.展开更多
Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, ...Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.52173271,51922022 and 51773013)the Beijing Outstanding Young Scientist Program(Grant No.BJJWZYJH01201910010024)+3 种基金the China Postdoctoral Science Foundation(Grant Nos.2021T140044 and 2020M670110)the Beijing Municipal Natural Science Foundation(Grant No.2214074)the Beijing Municipal Science and Technology Project(Grant No.Z191100006619099)the Fundamental Research Funds for the Central Universities(Grant Nos.BHYC1705A and XK1802-2)。
文摘Metal-organic frameworks(MOFs)composed of functional metal ions/clusters and suitable bridging ligands are highly designable,which have shown excellent catalytic activity as nanozymes and are promising for antibacterial therapy.Herein,twodimensional(2D)copper MOF nanosheets(Cu-MOF NSs)as effective antibacterial agents were prepared through a simple onestep method.The 2D Cu-MOF NSs displayed a peroxidase-like activity toward H_(2)O_(2)decomposition into highly cytotoxic hydroxyl radicals(·OH).Notably,the 2D morphology of Cu-MOF NSs provides a high density of Cu^(2+)/Cu^(+)surface active sites,which could efficiently oxidize the proteins and lipids on the bacterial surface and induce the death of bacteria.It is found that the as-prepared 2D Cu-MOF NSs exhibited antibacterial properties against Staphylococcus aureus(S.aureus)and could efficiently eradicate the biofilm of S.aureus.Up to 99.9%bacteria were killed at a Cu-MOF concentration of 4μg/m L.This study opens a new avenue for the design of MOF-based antibacterial agents to combat pathogenic bacterial infections.
基金supported by grants from the National Natural Science Foundation of China(No.52242208).
文摘Antioxidant collagen hydrolysates refers to the peptides mixture with antioxidant properties identified from hydrolyzed collagen.Due to its specific structural,biological and physicochemical properties,collagen hydrolysates have been explored as a multifunctional antioxidant in the biomedical field.In this review,we summarize recent advances in antioxidant collagen hydrolysates development.Initially,the preparation process of antioxidant collagen hydrolysates is introduced,including the production and separation methods.Then the effects and the mechanisms of amino acid composition and collagen peptide structure on the antioxidant activity of collagen hydrolysates are reviewed.Finally,the applications of antioxidant collagen hydrolysates in biomedical domains are summarized,with critical discussions about the advantages,current limitations and challenges to be resolved in the future.
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.52173271,52221006,and 51922022)Beijing Outstanding Young Scientist Program(Grant No.BJJWZYJH0120191001-0024)the Fundamental Research Funds for the Central Universities(Grant No.BHYC1705A).
文摘Immunotherapy brings new hope for tumor treatment by inducing immunogenic cell death(ICD)of tumor cells.However,insufficient immunogenicity and low immune response rate greatly limit antitumor immunity.Herein,by optimizing the composition and morphology,the rational design of Janus nanoparticles composed of Fe_(3)O_(4) nanospheres and SiO_(2)nanorods was realized for enhanced cancer immunotherapy through amplified ICD.After glucose oxidase(GOx)was loaded by the Janus nanoparticles,the resultant M-FS-GOx consumes glucose at tumor sites to generate gluconic acid and hydrogen peroxide(H_(2)O_(2))for starvation therapy while the H_(2)O_(2)supply promotes the production of highly toxic·OH to achieve effective chemodynamic therapy(CDT).Under a 1064 nm light irradiation,the photothermal effect of M-FS-GOx enhances the enzyme activity of GOx for improved starvation therapy.Furthermore,both tumor-associated antigens released during the process of ICD and the intrinsic immunoadjuvant property of M-FS-GOx stimulate dendritic cell maturation to activate antitumor immune responses.This work provides a promising strategy for the construction of Janus nanoparticles to achieve enhanced cancer immunotherapy through combination therapy-amplified ICD.
基金supported by the National Natural Science Foundation of China (52073218, 22135005, 51873162, 51933006,51988102, 52122310, 22075050, 51833008, 51733006, 51733001,52122304)Jiangsu Province Science Foundation for Youths(BK20200241)+3 种基金Science and Technology Commission of Shanghai Municipality (20JC1414902, 21511104900)Shanghai Municipal Education Commission (2017-01-07-00-07-E00062)the National Key Research and Development Program (2021YFA1201200) of Chinathe Zhejiang Provincial Key Research and Development Program (2020C01123)。
文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation.