Eight compounds(1-8)were isolated from Ailanthus altissima(Mill.)Swingle,including four lignans,three phenylpropanoids and a simple aromatic compound,their structures were identified by nuclear magnetic resonance spec...Eight compounds(1-8)were isolated from Ailanthus altissima(Mill.)Swingle,including four lignans,three phenylpropanoids and a simple aromatic compound,their structures were identified by nuclear magnetic resonance spectra and mass spectrometry data.Among them,compounds 1,3,5 and 8 were first obtained from this genus.In addition,free radical scavenging ability of compounds 1-8 were evaluated using DPPH,ABTS,and FRAP assays and the results showed that compound 2 exhibited potent antioxidant activity in DPPH and ABTS radical scavenging assays and compound 7 showed the highest value of FRAP radical scavenging.展开更多
Radix Pueraria(RP)has a long history of dual-use in medicine and food,and is well known as“Asian ginseng”.Recently,some studies about the effect of RP against glioma have been reported.However,little is elucidated a...Radix Pueraria(RP)has a long history of dual-use in medicine and food,and is well known as“Asian ginseng”.Recently,some studies about the effect of RP against glioma have been reported.However,little is elucidated about the molecular mechanism of interaction.This study used network pharmacology and molecular docking techniques to clarify the molecular mechanism of RP in the treatment of glioma.Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)was applied to screen potential active ingredients of RP and their targets.Targets for glioma were obtained from Genecards,OMIM,and Therapeutic Target Database(TTD).The topological analysis of cross-target and core target interaction was conducted using protein-protein interaction analysis(PPI).With the application of bioinformatics,GO and KEGG enrichment analyses were further carried out.Molecular docking was used then to validate the binding affinity between active components and key targets.This study successfully identified 6 potential active ingredients,namely beta-sitosterol,daidzein,formononetin,genistein,ononin,and puerarin.The hub targets were AKT1,TP53,VEGRA,EGFR,and MAPK3.These targets were mainly involved in biological processes,such as RNA polymerase II-specific DNA-binding transcription factor binding,and positive regulation of cell migration in the membrane raft,and were regulated by PI3K-Akt pathway.Further study showed that almost all the compounds had good binding abilities with above-mentioned targets.In short,this study systematically revealed the anti-glioma mechanism of RP to provide reference for the treatment of glioma.展开更多
Viburnum dilatatum(jiami in Chinese),belonging to the Caprifollaceae family,is widely distributed in Japan and China.Phytochemical investigations of Viburnum dilatatum(V.dilatatum)have resulted in the isolation of tri...Viburnum dilatatum(jiami in Chinese),belonging to the Caprifollaceae family,is widely distributed in Japan and China.Phytochemical investigations of Viburnum dilatatum(V.dilatatum)have resulted in the isolation of triterpenoids,phenolic glycosides essential oil,norisoprenoids,etc.Research results have shown that the chemical constituents of V.dilatatum possess various pharmacological activities,including antihyperglycemic,antioxidant activity and antiulcer effects.This study reviewed the chemical constituents and pharmacological activities of V.dilatatum to provide practical and useful information for further research and development of this plant.展开更多
Piper amalago(P.amalago)is a traditional medicine in Brazil for the treatment of leishmanial.Owing to its rare occurrence and potent pharmacological activities,efforts have been devoted to the identification of its di...Piper amalago(P.amalago)is a traditional medicine in Brazil for the treatment of leishmanial.Owing to its rare occurrence and potent pharmacological activities,efforts have been devoted to the identification of its diverse constituents,especially terpenoids.Researchers have found that the major constituents of P.amalago were amides,monoterpenes,norisoprenoids,sesquiterpenes,aliphatic hydrocarbons and aromatic hydrocarbons.The amides show anxiolytic,anti-inflammatory,antileishmanial and antinociceptive activity.This review summarizes the research progress of the structural diversity and pharmacological activities of P.amalago.展开更多
Solanum nigrum L.,belonging to the genus Solanum of Solanaceae family,is widely distributed in temperate and tropical regions of the world.It possesses the effects of clearing away heat and detoxification.A wide spect...Solanum nigrum L.,belonging to the genus Solanum of Solanaceae family,is widely distributed in temperate and tropical regions of the world.It possesses the effects of clearing away heat and detoxification.A wide spectrum of chemical constituents have been isolated from the Solanum nigrum L.,including lignans,steroids,etc.The structures of the eight compounds were determined by comprehensive spectroscopic analyses.It is noteworthy that compounds 1–4,6 and 8 have been isolated from Solanum nigrum L.for the first time.All compounds were evaluated for their antioxidant activities by ABTS and DPPH assays.Based on the results,Solanum nigrum L.could be used as a new natural antioxidant in biomedical applications.展开更多
Glioma is a common primary intracranial tumor with high mortality and postoperative recurrence.Developing efficient therapies with lower toxicity is urgently needed.Sophora flavescens(SF)is a common Chinese medicine u...Glioma is a common primary intracranial tumor with high mortality and postoperative recurrence.Developing efficient therapies with lower toxicity is urgently needed.Sophora flavescens(SF)is a common Chinese medicine used to treat eczema,wet ulcers and itchy skin.Modern pharmacological studies have showed that SF has anti-glioma effects,but the mechanism of action remains unclear.This study aims to reveal the pharmacological mechanism of SF in treating glioma.The active components and related targets of SF were obtained from TCMSP.Genecard and Online Mendelian Inheritance in Man(OMIM)databases were used to explore the therapeutic targets for glioma.By making Venn diagram,we obtained 132 common targets of compounds and diseases.STRING databases and Cytoscape were used to construct diagrams of Protein-Protein Interaction(PPI)networks.Through the construction of PPI network,potential targets with degree value greater than the median were taken as core targets for further analysis.A total of 66 core targets were screened out.The degree values of TP53,HSP90AA1,MAPK1,and AKT1 were higher,indicating that these genes played important roles in this network.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were used to further discover the mechanism of active components in SF.Through enrichment analysis,it was found that the core targets were mainly enriched in PI3K/AKT signaling pathway,cell senescence related signaling pathway and IL-17 signaling pathway.In order to further explore the binding between active components and selected target,molecular docking was carried out.Finally,SwissADME was used to determine whether the compound could cross the blood-brain barrier.Based on network pharmacology,we speculated that matrine and formononetin in SF might inhibit PI3K/AKT signaling pathway and cellular senescence related signaling pathway by targeting AKT1,TP53,MAPK1 and other key targets.In summary,this study preliminarily explored the target and mode of action of SF in the treatment of glioma,laying the foundation for further research on its mechanism.展开更多
The Piper betle,belonging to Piper genus of the Piperaceae family,is an evergreen and perennial creeper used in several traditional medicines.This plant has been known to possess antioxidant,antitumor,antibacterial,an...The Piper betle,belonging to Piper genus of the Piperaceae family,is an evergreen and perennial creeper used in several traditional medicines.This plant has been known to possess antioxidant,antitumor,antibacterial,anti-inflammatory and antimalarial activities.A wide range of chemical compounds including alkaloids,simple phenylpropanoids,lignans,flavonoids,steroids,triterpenoids,sesquiterpenes,monoterpenes have been isolated from this plant.The present review summarized the information concerning phytochemistry and biological activity of P.betle,providing references for the future research of this plant.展开更多
Daphne plants,belonging to Thymelaeaceae,have been used as traditional Chinese medicine for thousands of years.Previous studies suggested that they exerted anti-tumor activities and reported a number of compounds with...Daphne plants,belonging to Thymelaeaceae,have been used as traditional Chinese medicine for thousands of years.Previous studies suggested that they exerted anti-tumor activities and reported a number of compounds with anti-tumor activities,isolated from the genus Daphne.However,the targets of these compounds have not been determined yet.In this study,network pharmacology was used to analyze 128 terpenoid compounds from the genus Daphne and 49 target proteins of liver cancer.The results suggested that the target with the most number of directed edges was 5yz0.The compound which docked with 5yz0 best is AR.DT.25(acutilobin D),and the compounds with total docking score greater than 10 were almost all Daphnane diterpenoids.The network pharmacology results predicted that the 5yz0 protein was one of the potential targets of the terpenoids from the genus Daphne and then suggested several new targets and compounds for further liver cancer research.展开更多
Viburnum tinus L.is a shrub native to the Mediterranean basin.Because of its sedative and antispasmodic activities,it is often used as a folk medicine in Europe.Phytochemical researches have shown that numerous chemic...Viburnum tinus L.is a shrub native to the Mediterranean basin.Because of its sedative and antispasmodic activities,it is often used as a folk medicine in Europe.Phytochemical researches have shown that numerous chemical components,including iridoid glycosides,diterpenes,triterpenes,coumarin,flavonoids and anthocyanidins have been isolated from Viburnum tinus L..This study reviewed the chemical constituents and pharmacological activities of Viburnum tinus L.to provide a reference for further researches.展开更多
Phytochemical investigation of peanut testa(the seed coat of Arachis hypogaea L.)led to the isolation of eight phenolic compounds,including caffeic acid(1),methyl caffeate(2),ethyl caffeate(3),methyl protocatechuate(4...Phytochemical investigation of peanut testa(the seed coat of Arachis hypogaea L.)led to the isolation of eight phenolic compounds,including caffeic acid(1),methyl caffeate(2),ethyl caffeate(3),methyl protocatechuate(4),ethyl protocatechuate(5),butyl protocatechuate(6),(E)-p-hydroxycinnamic acid methyl ester(7),and resveratrol(8).The structures of the compounds were elucidated through spectroscopic data analysis and comparison with the previously reported literature.Among them,compounds 2,3,5,and 6 were obtained from Arachis hypogaea L.for the first time.展开更多
Periploca forrestii Schltr.belonging to the family of Apocynaceae,is one of the“three treasures of Miao medicine”,which was utilized by the Miao people in China for the treatment of rheumatoid arthritis,fractures an...Periploca forrestii Schltr.belonging to the family of Apocynaceae,is one of the“three treasures of Miao medicine”,which was utilized by the Miao people in China for the treatment of rheumatoid arthritis,fractures and wound.Phytochemical investigations have discovered that the main constituents of Periploca forrestii were steroids,terpenoids,flavonoids and their glycosides,flavanols,quinones and phenylpropanoids.Modern pharmacological studies have shown that it possesses a wide range of biological activities,such as anti-inflammatory,anti-rheumatoid arthritis,anticancer,immunosuppressive,neuroprotective and other properties.This paper summarized the primary chemical constituents and pharmacological effects of Periploca forrestii,hoping to provide a reference for its further development and utilization.展开更多
Litsea lancilimba Merr.is a Cinnamomum plant of Lauraceae.Phytochemical investigations of the Litsea lancilimba Merr.have resulted in the isolation of Volatile oil,flavonoid glycosides,tannins,alkaloids,lignans,organi...Litsea lancilimba Merr.is a Cinnamomum plant of Lauraceae.Phytochemical investigations of the Litsea lancilimba Merr.have resulted in the isolation of Volatile oil,flavonoid glycosides,tannins,alkaloids,lignans,organic acids and so on.Studies have showed that volatile oil is the main chemical component.Recent trials have demonstrated the efficacy of Litsea lancilimba Merr.in strengthening the function of stomach.The fruits have also been demonstrated to possess anti-inflammatory and bacteriostatic activities.This review deals mainly with the chemical structure and biological activities of Litsea lancilimba Merr.oil.展开更多
Piper nigrum L.,belonging to Piper genus of the Piperaceae family,is a medicinal and edible plant.Studies have shown that there are many chemical constituents in this plant,including alkaloids,lignans,steroids and oth...Piper nigrum L.,belonging to Piper genus of the Piperaceae family,is a medicinal and edible plant.Studies have shown that there are many chemical constituents in this plant,including alkaloids,lignans,steroids and other compounds.In addition,some chemical components of P.nigrum have potential values to treat cancer,inflammation and other diseases.Research progress on the chemical constituents and pharmacological effects of P.nigrum was reviewed in this study to better explore its potential medicinal value.展开更多
Plant of Daphne odora Thunb.has been used as medicinal plant since ancient times.In recent years,phytochemical studies have found that D.odora contains flavonoids,diflavonoids,coumarins,lignans,monoterpenes and other ...Plant of Daphne odora Thunb.has been used as medicinal plant since ancient times.In recent years,phytochemical studies have found that D.odora contains flavonoids,diflavonoids,coumarins,lignans,monoterpenes and other compounds,and shows extensive biological activities such as anti-inflammatory,immunomodulatory,neuroinhibition effects and so on.This article briefly reviews the recent research progress on the chemical constituents and pharmacological effects of D.odora at home and abroad.展开更多
Eight compounds,(+)-syringaresinol(1),apigenin(2),3,5-dimethoxy-4-hydxyphenylpropanol(3),3,4,5-trimethoxy benzoic acid,(4)ferulaic acid(5),trans-p-hydroxycinnamic methyl ester(6),4-hydroxy-3-methoxybenz-oic acid(7)and...Eight compounds,(+)-syringaresinol(1),apigenin(2),3,5-dimethoxy-4-hydxyphenylpropanol(3),3,4,5-trimethoxy benzoic acid,(4)ferulaic acid(5),trans-p-hydroxycinnamic methyl ester(6),4-hydroxy-3-methoxybenz-oic acid(7)and p-methoxy benzoic acid(8)were isolated from the 70%ethanol extract of the whole herb of Elephantopus scaber L.The structures of all compounds were identified by spectral data analysis.All compounds were obtained for the first time from Elephantopus scaber L..展开更多
Background:Prostate cancer(PCa)is one of the most common malignancies of the male genitourinary system.Commiphora myrrha(CM)has the potential to treat PCa,but the underlying mechanism is still unclear.Therefore,this s...Background:Prostate cancer(PCa)is one of the most common malignancies of the male genitourinary system.Commiphora myrrha(CM)has the potential to treat PCa,but the underlying mechanism is still unclear.Therefore,this study uses the network pharmacology method to investigate the target of CM in the treatment of PCa and related signal pathways,and further analyze the theoretical basis and potential mechanism of its treatment with PCa.Methods:All the components and targets of CM were retrieved from Traditional Chinese Medicine System Pharmacology Database and Analysis Platform(TCMSP).GeneCards and DisGeNET databases were used to collect PCa-related targets.String was used to build a target protein interaction network.The network of“active component-interaction target-related pathways”and protein-protein interaction network were constructed using Cytoscape,the functional enrichment analysis of GO and the enrichment analysis of KEGG pathway of CM in the treatment of PCa were performed using Metascape.Results:A total of 33 active ingredients including quercetin,β-sitosterol and ellagic acid were obtained,and 61 common targets of CM for PCa were obtained by screening intersection.The most frequent occurrences were AKT1,TP53,JUN,VEGFA,etc.These targets were mainly involved in biological processes,such as apoptotic signaling pathway,response to growth factor,and reactive oxygen species metabolic process,and were mainly concentrated in PI3K-Akt,MAPK and other signaling pathways.Conclusion:This study revealed the effective ingredients,potential targets and mechanism of action of CM in the treatment of PCa,aiming to provide a theoretical basis and reference for subsequent experimental studies.展开更多
Traditional Chinese medicine(TCM)Phellodendri Chinensis Cortex(PCC)has been used for the treatment of human hepatocellular carcinoma,but the underlying mechanisms are still unclear.In this study,15 active compositions...Traditional Chinese medicine(TCM)Phellodendri Chinensis Cortex(PCC)has been used for the treatment of human hepatocellular carcinoma,but the underlying mechanisms are still unclear.In this study,15 active compositions of PCC were obtained from Traditional Chinese Medicine Systems Pharmacology Database(TCMSP),and 505 putative identified targets of PCC were screened by Swiss Target Prediction server.Next,HCC data was downloaded from Drugbank and GeneCards databases.Furtherly,45 common targets were revealed.The network diagrams of the active component-target network,protein-protein interaction(PPI)network and active component-target-pathway network were constructed using Cytoscape software.The analysis of the network results showed that the active ingredients of PCC,such as berberine,obacunone,rutaecarpine,candletoxin A,palmatine,isocorypalmine,quercetin,and(S)-Canadine,had a good binding activity with more targets.Additionally,Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses revealed that common targets were significantly enriched in Ras signaling pathway,ErbB signaling pathway,and Mammalian target of rapamycin(mTOR)signaling pathway.Altogether,the multi-component,multi-target,and multi-pathway characteristics of PCC provided a reference for the in-depth study of the mechanism of PCC in the treatment of HCC.展开更多
Viburnum awabuki(V.awabuki),belonging to the Viburnum genus,is an ideal tree species for landscaping.Phytochemical investigations of the V.awabuki have resulted in the isolation and identification of coumarins,lignans...Viburnum awabuki(V.awabuki),belonging to the Viburnum genus,is an ideal tree species for landscaping.Phytochemical investigations of the V.awabuki have resulted in the isolation and identification of coumarins,lignans,sesquiterpenes,diterpenes and triterpenes.It has been reported that the extracts of V.awabuki have multiple pharmacological activities,including anti-tumor,anti-oxidant,plant growth inhibitory and neurite outgrowth-promoting activities.The research progress on the chemical constituents of V.awabuki and pharmacological activities were summarized in this review.展开更多
Ailanthus altissima(Mill.)Swingle is a deciduous tree belonging to the Simaroubaceae family.The root and stem bark are traditional medicines for treating many diseases,such as diarrhea,dreaminess and intestinal tract ...Ailanthus altissima(Mill.)Swingle is a deciduous tree belonging to the Simaroubaceae family.The root and stem bark are traditional medicines for treating many diseases,such as diarrhea,dreaminess and intestinal tract bleeding.Phytochemical investigation of Ailanthus altissima(Mill.)Swingle led to the isolation of eight compounds.Chemical structures of these compounds were identified by analyzing their NMR spectroscopic data.Among them,compounds 1,4,5,6 and 8 were isolated from Ailanthus Desf.for the first time.The antioxidant activities of these compounds were determined by DPPH radical scavenging method.展开更多
As a traditional Chinese medicine,Curcumae Radix(CR)has exhibited anti-hepatocellular carcinoma(HCC)activity.However,the underlying molecular mechanism is still unclear.In the present study,network pharmacology was ut...As a traditional Chinese medicine,Curcumae Radix(CR)has exhibited anti-hepatocellular carcinoma(HCC)activity.However,the underlying molecular mechanism is still unclear.In the present study,network pharmacology was utilized to reveal the mechanism of the effects of CR in HCC.The analysis of the network results showed that the active components of CR,including curcumin,naringenin,sitosterol,demethoxycurcumin,andβ-elemene,were closely related to the screened hub-targets,such as AKT1,TP53,MAPK8,MAPK1,JUN,STAT3,VEGFA,MAPK3,IL6,TNF,CCND1,EP300,EGFR,and ESR1.GO and KEGG analyses revealed that these targets were associated with pathways in cancer,proteoglycans in cancer,PI3K-Akt signaling pathway,AGE-RAGE signaling pathway in diabetic complications,MAPK signaling pathway,hepatitis B,hepatitis C,and other biological processes.The candidate active components of CR(curcumin and naringenin)prominently exhibited their antitumor effects by regulating PI3K-Akt signaling pathway,MAPK signaling pathway,hepatitis B and hepatitis C.This study successfully predicted,explained,and confirmed the multi-component,multi-target,and multi-channel characteristics of CR,which not only gave novel insights into the pharmacological and biological molecular mechanism of CR applying to HCC disease,but also provided a feasible method for discovering potential activated compounds from Chinese herbs.展开更多
文摘Eight compounds(1-8)were isolated from Ailanthus altissima(Mill.)Swingle,including four lignans,three phenylpropanoids and a simple aromatic compound,their structures were identified by nuclear magnetic resonance spectra and mass spectrometry data.Among them,compounds 1,3,5 and 8 were first obtained from this genus.In addition,free radical scavenging ability of compounds 1-8 were evaluated using DPPH,ABTS,and FRAP assays and the results showed that compound 2 exhibited potent antioxidant activity in DPPH and ABTS radical scavenging assays and compound 7 showed the highest value of FRAP radical scavenging.
文摘Radix Pueraria(RP)has a long history of dual-use in medicine and food,and is well known as“Asian ginseng”.Recently,some studies about the effect of RP against glioma have been reported.However,little is elucidated about the molecular mechanism of interaction.This study used network pharmacology and molecular docking techniques to clarify the molecular mechanism of RP in the treatment of glioma.Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)was applied to screen potential active ingredients of RP and their targets.Targets for glioma were obtained from Genecards,OMIM,and Therapeutic Target Database(TTD).The topological analysis of cross-target and core target interaction was conducted using protein-protein interaction analysis(PPI).With the application of bioinformatics,GO and KEGG enrichment analyses were further carried out.Molecular docking was used then to validate the binding affinity between active components and key targets.This study successfully identified 6 potential active ingredients,namely beta-sitosterol,daidzein,formononetin,genistein,ononin,and puerarin.The hub targets were AKT1,TP53,VEGRA,EGFR,and MAPK3.These targets were mainly involved in biological processes,such as RNA polymerase II-specific DNA-binding transcription factor binding,and positive regulation of cell migration in the membrane raft,and were regulated by PI3K-Akt pathway.Further study showed that almost all the compounds had good binding abilities with above-mentioned targets.In short,this study systematically revealed the anti-glioma mechanism of RP to provide reference for the treatment of glioma.
文摘Viburnum dilatatum(jiami in Chinese),belonging to the Caprifollaceae family,is widely distributed in Japan and China.Phytochemical investigations of Viburnum dilatatum(V.dilatatum)have resulted in the isolation of triterpenoids,phenolic glycosides essential oil,norisoprenoids,etc.Research results have shown that the chemical constituents of V.dilatatum possess various pharmacological activities,including antihyperglycemic,antioxidant activity and antiulcer effects.This study reviewed the chemical constituents and pharmacological activities of V.dilatatum to provide practical and useful information for further research and development of this plant.
文摘Piper amalago(P.amalago)is a traditional medicine in Brazil for the treatment of leishmanial.Owing to its rare occurrence and potent pharmacological activities,efforts have been devoted to the identification of its diverse constituents,especially terpenoids.Researchers have found that the major constituents of P.amalago were amides,monoterpenes,norisoprenoids,sesquiterpenes,aliphatic hydrocarbons and aromatic hydrocarbons.The amides show anxiolytic,anti-inflammatory,antileishmanial and antinociceptive activity.This review summarizes the research progress of the structural diversity and pharmacological activities of P.amalago.
文摘Solanum nigrum L.,belonging to the genus Solanum of Solanaceae family,is widely distributed in temperate and tropical regions of the world.It possesses the effects of clearing away heat and detoxification.A wide spectrum of chemical constituents have been isolated from the Solanum nigrum L.,including lignans,steroids,etc.The structures of the eight compounds were determined by comprehensive spectroscopic analyses.It is noteworthy that compounds 1–4,6 and 8 have been isolated from Solanum nigrum L.for the first time.All compounds were evaluated for their antioxidant activities by ABTS and DPPH assays.Based on the results,Solanum nigrum L.could be used as a new natural antioxidant in biomedical applications.
基金National College Student Innovation and Entrepreneurship Training Program(202110163030).
文摘Glioma is a common primary intracranial tumor with high mortality and postoperative recurrence.Developing efficient therapies with lower toxicity is urgently needed.Sophora flavescens(SF)is a common Chinese medicine used to treat eczema,wet ulcers and itchy skin.Modern pharmacological studies have showed that SF has anti-glioma effects,but the mechanism of action remains unclear.This study aims to reveal the pharmacological mechanism of SF in treating glioma.The active components and related targets of SF were obtained from TCMSP.Genecard and Online Mendelian Inheritance in Man(OMIM)databases were used to explore the therapeutic targets for glioma.By making Venn diagram,we obtained 132 common targets of compounds and diseases.STRING databases and Cytoscape were used to construct diagrams of Protein-Protein Interaction(PPI)networks.Through the construction of PPI network,potential targets with degree value greater than the median were taken as core targets for further analysis.A total of 66 core targets were screened out.The degree values of TP53,HSP90AA1,MAPK1,and AKT1 were higher,indicating that these genes played important roles in this network.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were used to further discover the mechanism of active components in SF.Through enrichment analysis,it was found that the core targets were mainly enriched in PI3K/AKT signaling pathway,cell senescence related signaling pathway and IL-17 signaling pathway.In order to further explore the binding between active components and selected target,molecular docking was carried out.Finally,SwissADME was used to determine whether the compound could cross the blood-brain barrier.Based on network pharmacology,we speculated that matrine and formononetin in SF might inhibit PI3K/AKT signaling pathway and cellular senescence related signaling pathway by targeting AKT1,TP53,MAPK1 and other key targets.In summary,this study preliminarily explored the target and mode of action of SF in the treatment of glioma,laying the foundation for further research on its mechanism.
文摘The Piper betle,belonging to Piper genus of the Piperaceae family,is an evergreen and perennial creeper used in several traditional medicines.This plant has been known to possess antioxidant,antitumor,antibacterial,anti-inflammatory and antimalarial activities.A wide range of chemical compounds including alkaloids,simple phenylpropanoids,lignans,flavonoids,steroids,triterpenoids,sesquiterpenes,monoterpenes have been isolated from this plant.The present review summarized the information concerning phytochemistry and biological activity of P.betle,providing references for the future research of this plant.
文摘Daphne plants,belonging to Thymelaeaceae,have been used as traditional Chinese medicine for thousands of years.Previous studies suggested that they exerted anti-tumor activities and reported a number of compounds with anti-tumor activities,isolated from the genus Daphne.However,the targets of these compounds have not been determined yet.In this study,network pharmacology was used to analyze 128 terpenoid compounds from the genus Daphne and 49 target proteins of liver cancer.The results suggested that the target with the most number of directed edges was 5yz0.The compound which docked with 5yz0 best is AR.DT.25(acutilobin D),and the compounds with total docking score greater than 10 were almost all Daphnane diterpenoids.The network pharmacology results predicted that the 5yz0 protein was one of the potential targets of the terpenoids from the genus Daphne and then suggested several new targets and compounds for further liver cancer research.
文摘Viburnum tinus L.is a shrub native to the Mediterranean basin.Because of its sedative and antispasmodic activities,it is often used as a folk medicine in Europe.Phytochemical researches have shown that numerous chemical components,including iridoid glycosides,diterpenes,triterpenes,coumarin,flavonoids and anthocyanidins have been isolated from Viburnum tinus L..This study reviewed the chemical constituents and pharmacological activities of Viburnum tinus L.to provide a reference for further researches.
文摘Phytochemical investigation of peanut testa(the seed coat of Arachis hypogaea L.)led to the isolation of eight phenolic compounds,including caffeic acid(1),methyl caffeate(2),ethyl caffeate(3),methyl protocatechuate(4),ethyl protocatechuate(5),butyl protocatechuate(6),(E)-p-hydroxycinnamic acid methyl ester(7),and resveratrol(8).The structures of the compounds were elucidated through spectroscopic data analysis and comparison with the previously reported literature.Among them,compounds 2,3,5,and 6 were obtained from Arachis hypogaea L.for the first time.
文摘Periploca forrestii Schltr.belonging to the family of Apocynaceae,is one of the“three treasures of Miao medicine”,which was utilized by the Miao people in China for the treatment of rheumatoid arthritis,fractures and wound.Phytochemical investigations have discovered that the main constituents of Periploca forrestii were steroids,terpenoids,flavonoids and their glycosides,flavanols,quinones and phenylpropanoids.Modern pharmacological studies have shown that it possesses a wide range of biological activities,such as anti-inflammatory,anti-rheumatoid arthritis,anticancer,immunosuppressive,neuroprotective and other properties.This paper summarized the primary chemical constituents and pharmacological effects of Periploca forrestii,hoping to provide a reference for its further development and utilization.
文摘Litsea lancilimba Merr.is a Cinnamomum plant of Lauraceae.Phytochemical investigations of the Litsea lancilimba Merr.have resulted in the isolation of Volatile oil,flavonoid glycosides,tannins,alkaloids,lignans,organic acids and so on.Studies have showed that volatile oil is the main chemical component.Recent trials have demonstrated the efficacy of Litsea lancilimba Merr.in strengthening the function of stomach.The fruits have also been demonstrated to possess anti-inflammatory and bacteriostatic activities.This review deals mainly with the chemical structure and biological activities of Litsea lancilimba Merr.oil.
文摘Piper nigrum L.,belonging to Piper genus of the Piperaceae family,is a medicinal and edible plant.Studies have shown that there are many chemical constituents in this plant,including alkaloids,lignans,steroids and other compounds.In addition,some chemical components of P.nigrum have potential values to treat cancer,inflammation and other diseases.Research progress on the chemical constituents and pharmacological effects of P.nigrum was reviewed in this study to better explore its potential medicinal value.
文摘Plant of Daphne odora Thunb.has been used as medicinal plant since ancient times.In recent years,phytochemical studies have found that D.odora contains flavonoids,diflavonoids,coumarins,lignans,monoterpenes and other compounds,and shows extensive biological activities such as anti-inflammatory,immunomodulatory,neuroinhibition effects and so on.This article briefly reviews the recent research progress on the chemical constituents and pharmacological effects of D.odora at home and abroad.
文摘Eight compounds,(+)-syringaresinol(1),apigenin(2),3,5-dimethoxy-4-hydxyphenylpropanol(3),3,4,5-trimethoxy benzoic acid,(4)ferulaic acid(5),trans-p-hydroxycinnamic methyl ester(6),4-hydroxy-3-methoxybenz-oic acid(7)and p-methoxy benzoic acid(8)were isolated from the 70%ethanol extract of the whole herb of Elephantopus scaber L.The structures of all compounds were identified by spectral data analysis.All compounds were obtained for the first time from Elephantopus scaber L..
文摘Background:Prostate cancer(PCa)is one of the most common malignancies of the male genitourinary system.Commiphora myrrha(CM)has the potential to treat PCa,but the underlying mechanism is still unclear.Therefore,this study uses the network pharmacology method to investigate the target of CM in the treatment of PCa and related signal pathways,and further analyze the theoretical basis and potential mechanism of its treatment with PCa.Methods:All the components and targets of CM were retrieved from Traditional Chinese Medicine System Pharmacology Database and Analysis Platform(TCMSP).GeneCards and DisGeNET databases were used to collect PCa-related targets.String was used to build a target protein interaction network.The network of“active component-interaction target-related pathways”and protein-protein interaction network were constructed using Cytoscape,the functional enrichment analysis of GO and the enrichment analysis of KEGG pathway of CM in the treatment of PCa were performed using Metascape.Results:A total of 33 active ingredients including quercetin,β-sitosterol and ellagic acid were obtained,and 61 common targets of CM for PCa were obtained by screening intersection.The most frequent occurrences were AKT1,TP53,JUN,VEGFA,etc.These targets were mainly involved in biological processes,such as apoptotic signaling pathway,response to growth factor,and reactive oxygen species metabolic process,and were mainly concentrated in PI3K-Akt,MAPK and other signaling pathways.Conclusion:This study revealed the effective ingredients,potential targets and mechanism of action of CM in the treatment of PCa,aiming to provide a theoretical basis and reference for subsequent experimental studies.
文摘Traditional Chinese medicine(TCM)Phellodendri Chinensis Cortex(PCC)has been used for the treatment of human hepatocellular carcinoma,but the underlying mechanisms are still unclear.In this study,15 active compositions of PCC were obtained from Traditional Chinese Medicine Systems Pharmacology Database(TCMSP),and 505 putative identified targets of PCC were screened by Swiss Target Prediction server.Next,HCC data was downloaded from Drugbank and GeneCards databases.Furtherly,45 common targets were revealed.The network diagrams of the active component-target network,protein-protein interaction(PPI)network and active component-target-pathway network were constructed using Cytoscape software.The analysis of the network results showed that the active ingredients of PCC,such as berberine,obacunone,rutaecarpine,candletoxin A,palmatine,isocorypalmine,quercetin,and(S)-Canadine,had a good binding activity with more targets.Additionally,Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses revealed that common targets were significantly enriched in Ras signaling pathway,ErbB signaling pathway,and Mammalian target of rapamycin(mTOR)signaling pathway.Altogether,the multi-component,multi-target,and multi-pathway characteristics of PCC provided a reference for the in-depth study of the mechanism of PCC in the treatment of HCC.
文摘Viburnum awabuki(V.awabuki),belonging to the Viburnum genus,is an ideal tree species for landscaping.Phytochemical investigations of the V.awabuki have resulted in the isolation and identification of coumarins,lignans,sesquiterpenes,diterpenes and triterpenes.It has been reported that the extracts of V.awabuki have multiple pharmacological activities,including anti-tumor,anti-oxidant,plant growth inhibitory and neurite outgrowth-promoting activities.The research progress on the chemical constituents of V.awabuki and pharmacological activities were summarized in this review.
文摘Ailanthus altissima(Mill.)Swingle is a deciduous tree belonging to the Simaroubaceae family.The root and stem bark are traditional medicines for treating many diseases,such as diarrhea,dreaminess and intestinal tract bleeding.Phytochemical investigation of Ailanthus altissima(Mill.)Swingle led to the isolation of eight compounds.Chemical structures of these compounds were identified by analyzing their NMR spectroscopic data.Among them,compounds 1,4,5,6 and 8 were isolated from Ailanthus Desf.for the first time.The antioxidant activities of these compounds were determined by DPPH radical scavenging method.
文摘As a traditional Chinese medicine,Curcumae Radix(CR)has exhibited anti-hepatocellular carcinoma(HCC)activity.However,the underlying molecular mechanism is still unclear.In the present study,network pharmacology was utilized to reveal the mechanism of the effects of CR in HCC.The analysis of the network results showed that the active components of CR,including curcumin,naringenin,sitosterol,demethoxycurcumin,andβ-elemene,were closely related to the screened hub-targets,such as AKT1,TP53,MAPK8,MAPK1,JUN,STAT3,VEGFA,MAPK3,IL6,TNF,CCND1,EP300,EGFR,and ESR1.GO and KEGG analyses revealed that these targets were associated with pathways in cancer,proteoglycans in cancer,PI3K-Akt signaling pathway,AGE-RAGE signaling pathway in diabetic complications,MAPK signaling pathway,hepatitis B,hepatitis C,and other biological processes.The candidate active components of CR(curcumin and naringenin)prominently exhibited their antitumor effects by regulating PI3K-Akt signaling pathway,MAPK signaling pathway,hepatitis B and hepatitis C.This study successfully predicted,explained,and confirmed the multi-component,multi-target,and multi-channel characteristics of CR,which not only gave novel insights into the pharmacological and biological molecular mechanism of CR applying to HCC disease,but also provided a feasible method for discovering potential activated compounds from Chinese herbs.