β-C(sp^(3))−H chlorination of amide derivatives via photoinduced copper charge transfer catalysis

An atom economicβ-C(sp^(3))−H chlorination of amide derivatives has been developed.This mild protocol employs CuCl_(2) instead of palladium catalysts with atom-economic HCl as chlorine sources and enables the late-stage functionalization of medicine derivatives.Mechanism studies suggest a plausible visible light triggered ligand-to-metal charge transfer(LMCT)/1,4-hydrogen atom transfer(HAT)cascade.

Visible-light-enabled ruthenium-catalyzed para-C-H difluoroalkylation of anilides

Visible-light-mediated para-C-H difluoroalkylation of anilides via combination of steric effects and Lewis acid activation strategies has been developed. The addition of(C_6H_5O)_(2)P(O)OH and Ag_(2)CO_(3) properly tune the redox potential of ruthenium catalyst and leads to mild reaction conditions. The protocol exhibits broad functional group tolerance and allows the late-stage functionalization of complex bioactive molecules.

Ruthenium(Ⅱ)-catalyzed para-selective C—H difluoroalkylation of aromatic aldehydes and ketones using transient directing groups

A Ru(Ⅱ)-catalyzed para-difluoroalkylation of aro matic alde hydes and ketones with a tra nsient directing group has been developed.It utilizes less expensive ruthenium catalysts and allows facile access to challenging difluoroalkylated aldehydes.The mechanism studies suggest that the distinct coordination mode of ruthenium complex with imine moieties is responsible for para-selectivity.