Based on a number of published and unpublished single-cell RNAsequencing(scRNA-seq)datasets,a recent study identified putative specific cell subtypes targeted by SARS-CoV-2(severe acute respiratory syndrome coronaviru...Based on a number of published and unpublished single-cell RNAsequencing(scRNA-seq)datasets,a recent study identified putative specific cell subtypes targeted by SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)and a possible role of interferon(IFN)in its pathogenesis.The rapid spread of SARS-CoV-2,the causative pathogen of COVID-19,has had global public health and economic consequences.The molecular mechanism(s)underlying the high transmissibility of SARS-CoV-2 remain(s)elusive.Therefore,we must follow a pragmatic and stepwise path to determine the specific target cell subsets and factors that regulate SARS-CoV-2 infection to elucidate true targets for treatment.In a recent issue of Cell,Carly and co-workers1 identified the cell subsets targeted by SARS-CoV-2 in certain tissues.In addition,they found that IFN-αenhanced the expression of angiotensin-converting enzyme 2(ACE2),the receptor for SARS-CoV-2,in primary human upper airway basal cells.However,we know that IFN is cell-type-and host speciesspecific,indicating the need for more preclinical and clinical data to clarify the role of IFN in the pathogenesis of COVID-19.展开更多
文摘Based on a number of published and unpublished single-cell RNAsequencing(scRNA-seq)datasets,a recent study identified putative specific cell subtypes targeted by SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)and a possible role of interferon(IFN)in its pathogenesis.The rapid spread of SARS-CoV-2,the causative pathogen of COVID-19,has had global public health and economic consequences.The molecular mechanism(s)underlying the high transmissibility of SARS-CoV-2 remain(s)elusive.Therefore,we must follow a pragmatic and stepwise path to determine the specific target cell subsets and factors that regulate SARS-CoV-2 infection to elucidate true targets for treatment.In a recent issue of Cell,Carly and co-workers1 identified the cell subsets targeted by SARS-CoV-2 in certain tissues.In addition,they found that IFN-αenhanced the expression of angiotensin-converting enzyme 2(ACE2),the receptor for SARS-CoV-2,in primary human upper airway basal cells.However,we know that IFN is cell-type-and host speciesspecific,indicating the need for more preclinical and clinical data to clarify the role of IFN in the pathogenesis of COVID-19.
