Dear Editor, Endocytosis is a crucial process employed by cells to internal- ize nutrients and turnover membrane components and is essential for many functions, including nutrient uptake, signal transduction, cytokine...Dear Editor, Endocytosis is a crucial process employed by cells to internal- ize nutrients and turnover membrane components and is essential for many functions, including nutrient uptake, signal transduction, cytokinesis, morphogenesis, cell adhesion and migration. Endocytosis is classified as clathrin-dependent endocytosis (CDE) or clathrin-independent endocytosis (CIE) according to its dependence on clathrin. Several different CIE pathways have been proposed, including caveolin-dependent endocytosis, flotillin-dependent endocytosis, the clathrin-inde- pendent carrier pathway, ARF6-dependent endocytosis, phagocytosis, macropinocytosis, the IL2RI3 pathway (Doherty and McMahon, 2009), the newly identified fast endophilin-me- diated endocytosis pathway (Boucrot et al., 2015) and the EGFR-NCE pathway (Caldieri et al., 2017).展开更多
文摘Dear Editor, Endocytosis is a crucial process employed by cells to internal- ize nutrients and turnover membrane components and is essential for many functions, including nutrient uptake, signal transduction, cytokinesis, morphogenesis, cell adhesion and migration. Endocytosis is classified as clathrin-dependent endocytosis (CDE) or clathrin-independent endocytosis (CIE) according to its dependence on clathrin. Several different CIE pathways have been proposed, including caveolin-dependent endocytosis, flotillin-dependent endocytosis, the clathrin-inde- pendent carrier pathway, ARF6-dependent endocytosis, phagocytosis, macropinocytosis, the IL2RI3 pathway (Doherty and McMahon, 2009), the newly identified fast endophilin-me- diated endocytosis pathway (Boucrot et al., 2015) and the EGFR-NCE pathway (Caldieri et al., 2017).