Biocompatible magnetic nanoparticles were prepared by co-precipitation method in the presence of poly(aspartic acid)(PAsp)as stabilizer,which was one of the most extensively studied and used poly(amino acids).As a bio...Biocompatible magnetic nanoparticles were prepared by co-precipitation method in the presence of poly(aspartic acid)(PAsp)as stabilizer,which was one of the most extensively studied and used poly(amino acids).As a biocompatible dispersant,PAsp was successfully attached to the Fe_(3)O_(4) nanoparticles,which was approved by Fourier transform infrared spectroscopy(FTIR),transmission electron microscopy(TEM)and thermogravimetric analysis(TGA).From X-ray diffraction(XRD)and vibrating sample magnetometry(VSM)measurement results,it was found that PAsp stabilized iron oxide nanoparticles possess excellent Fe_(3)O_(4) crystal structure and superparamagnetic property.Compared with trisodium citrate stabilized magnetic nanoparticles,PAsp stabilized magnetic nanoparticles were biocompatible and with lower cytotoxicity,which makes it more applicable in medicine,biology and biomaterial science.展开更多
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.20974023,21034003 and 51073040)Shanghai Committee of Science and Technology,China(Grant No.10XD1400500).
文摘Biocompatible magnetic nanoparticles were prepared by co-precipitation method in the presence of poly(aspartic acid)(PAsp)as stabilizer,which was one of the most extensively studied and used poly(amino acids).As a biocompatible dispersant,PAsp was successfully attached to the Fe_(3)O_(4) nanoparticles,which was approved by Fourier transform infrared spectroscopy(FTIR),transmission electron microscopy(TEM)and thermogravimetric analysis(TGA).From X-ray diffraction(XRD)and vibrating sample magnetometry(VSM)measurement results,it was found that PAsp stabilized iron oxide nanoparticles possess excellent Fe_(3)O_(4) crystal structure and superparamagnetic property.Compared with trisodium citrate stabilized magnetic nanoparticles,PAsp stabilized magnetic nanoparticles were biocompatible and with lower cytotoxicity,which makes it more applicable in medicine,biology and biomaterial science.
