Fiber optofluidic laser(FOFL)integrates optical fiber microcavity and microfluidic channel and provides many unique advantages for sensing applications.FOFLs not only inherit the advantages of lasers such as high sens...Fiber optofluidic laser(FOFL)integrates optical fiber microcavity and microfluidic channel and provides many unique advantages for sensing applications.FOFLs not only inherit the advantages of lasers such as high sensitivity,high signal-to-noise ratio,and narrow linewidth,but also hold the unique features of optical fiber,including ease of integration,high repeatability,and low cost.With the development of new fiber structures and fabrication technologies,FOFLs become an important branch of optical fiber sensors,especially for application in biochemical detection.In this paper,the recent progress on FOFL is reviewed.We focuse mainly on the optical fiber resonators,gain medium,and the emerging sen sing applicatio ns.The prospects for FOFL are also discussed.We believe that the FOFL sensor provides a promising technology for biomedical analysis and environmental monitoring.展开更多
The excitation of the surface field and evanescent enhancement in the graphene have shown sensitive to the refractive index of surrounding media and potential applications in high-sensitivity biochemical sensing. In t...The excitation of the surface field and evanescent enhancement in the graphene have shown sensitive to the refractive index of surrounding media and potential applications in high-sensitivity biochemical sensing. In this paper, we investigate the graphene-coated microfiber Bragg gratings （GMFBGs） with different diameters for ammonia gas sensing. The maximum sensitivity with 6pm/ppm was achieved experimentally when the microfiber＇s diameter was about 10 μm. Moreover, by adjusting the diameter of the GMFBG, the sensing performance of the GMFBGs could be optimized. Experimental results indicated that GMFBGs with the diameter of 8μm - 12μm would show the characteristics of the high sensitivity, relative low attenuation, and large dynamic range.展开更多
Biomarker detection is key to identifying health risks.However,designing sensitive and single-use biosensors for early diagnosis remains a major challenge.Here,we report submonolayer lasers on optical fibers as ultras...Biomarker detection is key to identifying health risks.However,designing sensitive and single-use biosensors for early diagnosis remains a major challenge.Here,we report submonolayer lasers on optical fibers as ultrasensitive and disposable biosensors.Telecom optical fibers serve as distributed optical microcavities with high Q-factor,great repeatability,and ultralow cost,which enables whispering-gallery laser emission to detect biomarkers.It is found that the sensing performance strongly depends on the number of gain molecules.The submonolayer lasers obtained a six-order-of-magnitude improvement in the lower limit of detection(LOD)when compared to saturated monolayer lasers.We further achieve an ultrasensitive immunoassay for a Parkinson's disease biomarker,alpha-synuclein(α-syn),with a lower LOD of 0.32 pM in serum,which is three orders of magnitude lower than theα-syn concentration in the serum of Parkinson's disease patients.Our demonstration of submonolayer biolaser offers great potentials in high-throughput clinical diagnosis with ultimate sensitivity.展开更多
基金the financial support from the National Natural Science Foundation of China(Grant No.61875034)the 111 Project(Grant No.B14039)Seeding Project of Scientific and Technical Innovation of Sichuan Province(Grant No.2020107).
文摘Fiber optofluidic laser(FOFL)integrates optical fiber microcavity and microfluidic channel and provides many unique advantages for sensing applications.FOFLs not only inherit the advantages of lasers such as high sensitivity,high signal-to-noise ratio,and narrow linewidth,but also hold the unique features of optical fiber,including ease of integration,high repeatability,and low cost.With the development of new fiber structures and fabrication technologies,FOFLs become an important branch of optical fiber sensors,especially for application in biochemical detection.In this paper,the recent progress on FOFL is reviewed.We focuse mainly on the optical fiber resonators,gain medium,and the emerging sen sing applicatio ns.The prospects for FOFL are also discussed.We believe that the FOFL sensor provides a promising technology for biomedical analysis and environmental monitoring.
基金This work is supported by the National Natural Science Foundation of China （61107073, 61107072 and 61290312）, Fundamental Research Funds for the Central Universities （ZYGX2011J002）, Research Fund for the Doctoral Program of Higher Education of China （20110185120020）, Program for Changjiang Scholars and Innovative Research Team in University （PCSIRT, IRT1218）, and the 111 Project （B 14039）. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author（s） and source are credited.
基金The authors greatly thank Dr. Zegao Wang and Prof. Yuanfu Chen of the State Key Lab of Electronic Thin Films and Integrated Devices, University of Electronic Science ＆ Technology of China, for their help on the preparation and test of the graphene used in the study and useful discussions. This work was supported by the National Natural Science Foundation of China under Grant 61290312, 61107072, and 61107073. It was also supported by Program for Changjiang Scholars and Innovative Research Team in Universities of China （PCSIRT） and the ＂111 Project＂ of China Education Ministry.
文摘The excitation of the surface field and evanescent enhancement in the graphene have shown sensitive to the refractive index of surrounding media and potential applications in high-sensitivity biochemical sensing. In this paper, we investigate the graphene-coated microfiber Bragg gratings （GMFBGs） with different diameters for ammonia gas sensing. The maximum sensitivity with 6pm/ppm was achieved experimentally when the microfiber＇s diameter was about 10 μm. Moreover, by adjusting the diameter of the GMFBG, the sensing performance of the GMFBGs could be optimized. Experimental results indicated that GMFBGs with the diameter of 8μm - 12μm would show the characteristics of the high sensitivity, relative low attenuation, and large dynamic range.
基金This work is supported by National Natural Science Foundation of China （61107073, 61107072 and 61290312）, Fundamental Research Funds for the Central Universities （ZYGX2011J002）, Research Fund for the Doctoral Program of Higher Education of China （20110185120020）, Program for Changjiang Scholars and Innovative Research Team in University （PCSIRT, IRT1218）, and the 111 Project （B 14039）.
基金This work is supported by the National Natural Science Foundation of China （61107073, 61107072, and 61290312）, Fundamental Research Funds for the Central Universities （ZYGX2011J002）, Research Fund for the Doctoral Program of Higher Education of China （20110185120020）, Program for Changjiang Scholars and Innovative Research Team in University （PCSIRT, IRT1218）, and the 111 Project （B 14039）.
基金This work is supported by the National Natural Science Foundation of China(Grant Nos.62275043,61875034,62205007,11825402,and 62105006)the 111 Project(B14039)+4 种基金the Sichuan Science and Technology Program(2021YJ0101)the Fundamental Research Funds for the Central Universities(ZYGX2021YGCX007)the China Postdoctoral Science Foundation(Grant Nos.2021T1400232020M680187,and 2021M700208)the Young Elite Scientists Sponsorship Program by CAST(2022QNRC001)。
文摘Biomarker detection is key to identifying health risks.However,designing sensitive and single-use biosensors for early diagnosis remains a major challenge.Here,we report submonolayer lasers on optical fibers as ultrasensitive and disposable biosensors.Telecom optical fibers serve as distributed optical microcavities with high Q-factor,great repeatability,and ultralow cost,which enables whispering-gallery laser emission to detect biomarkers.It is found that the sensing performance strongly depends on the number of gain molecules.The submonolayer lasers obtained a six-order-of-magnitude improvement in the lower limit of detection(LOD)when compared to saturated monolayer lasers.We further achieve an ultrasensitive immunoassay for a Parkinson's disease biomarker,alpha-synuclein(α-syn),with a lower LOD of 0.32 pM in serum,which is three orders of magnitude lower than theα-syn concentration in the serum of Parkinson's disease patients.Our demonstration of submonolayer biolaser offers great potentials in high-throughput clinical diagnosis with ultimate sensitivity.
