An efficient and highly stereoselective synthetic method to access polycyclic chromanes has been achieved through organocatalyzed one-pot step-wise reactions involving 2-hydroxycinnamaldehydes,2-aminochalcones,and mal...An efficient and highly stereoselective synthetic method to access polycyclic chromanes has been achieved through organocatalyzed one-pot step-wise reactions involving 2-hydroxycinnamaldehydes,2-aminochalcones,and malononitrile as substrates.The reactions underwent a quintuple process by aza-Michael/Michael/Knoevenagel/oxa-Michael/aldol-type reaction in sequence to give products bearing 3 new generated rings and 5 chiral centers in moderate to quantitative yields with excellent stereoselectivities.展开更多
基金supported by the Advanced Talents Incubation Program of Hebei University(521000981411)the National Nature Science Foundation of China(82273792),Science Research Project of Hebei Education Department(QN2021023)+2 种基金the Natural Science Interdisciplinary Research Program of Hebei_University(DXK201913)High-throughput Intelligent Integrated Lung Cancer Targeted Drug Development Innovation Team Project(IT2023c01)the Excellent Youth Research Innovation Team of Hebei University(QNTD202406).
文摘An efficient and highly stereoselective synthetic method to access polycyclic chromanes has been achieved through organocatalyzed one-pot step-wise reactions involving 2-hydroxycinnamaldehydes,2-aminochalcones,and malononitrile as substrates.The reactions underwent a quintuple process by aza-Michael/Michael/Knoevenagel/oxa-Michael/aldol-type reaction in sequence to give products bearing 3 new generated rings and 5 chiral centers in moderate to quantitative yields with excellent stereoselectivities.
