Fifty-six compounds have been isolated from Abrus mollis until now,including saponins,steroids,flavonoids and fatty acid,which have the functions of promoting blood circulation to remove blood stasis,protecting the li...Fifty-six compounds have been isolated from Abrus mollis until now,including saponins,steroids,flavonoids and fatty acid,which have the functions of promoting blood circulation to remove blood stasis,protecting the liver and promoting gallbladder,anti-oxidation and enhancing immunity,etc.A.mollis has good therapeutic effects on liver diseases.In this paper,the chemical constituents and pharmacological effects of A.mollis were reviewed in order to provide a reference for the further development.展开更多
A gold(Ⅰ)-catalyzed 6-endo-dig cyclization of aromatic 1,5-enynes was developed to synthesize 2-(naphthalen-2-yl)anilines.The functional group tolerance of this cyclization was examined systematically and a possible ...A gold(Ⅰ)-catalyzed 6-endo-dig cyclization of aromatic 1,5-enynes was developed to synthesize 2-(naphthalen-2-yl)anilines.The functional group tolerance of this cyclization was examined systematically and a possible mechanism was proposed.The derivatization of 2-(naphthalen-2-yl)aniline was carried out to facile access to benzo[α]carbazole,benzo[c,h]cinnoline and dibenzo[i]phenanthridine derivatives in a divergent way.展开更多
The present study was designed to investigate the chemical constituents of the fruit of Citrus aurantium L.. The compounds were isolated and purified by various chromatographic techniques, and their structures were el...The present study was designed to investigate the chemical constituents of the fruit of Citrus aurantium L.. The compounds were isolated and purified by various chromatographic techniques, and their structures were elucidated on the basis of physicochemical properties and spectral data. Two new phenolic glycosides(compounds 1 and 2) were obtained and identified as 1-O-3, 5-dihydroxyphenyl-(6-O-4-hydroxybenzoyl)-β-D-glucopyranoside(1) and 1-O-3, 5-dihydroxyphenyl-(6-O-3-methoxy-4-hydroxy benzoyl)-β-D-glucopyranoside(2), respectively.展开更多
Based on our previous work,a series of hydrazone moiety-bearing aminopyrimidines were synthesized.The compounds were evaluated for inhibitory activities against EGFRT790M/L858 R and antiproliferative activities agains...Based on our previous work,a series of hydrazone moiety-bearing aminopyrimidines were synthesized.The compounds were evaluated for inhibitory activities against EGFRT790M/L858 R and antiproliferative activities against H1975 and A549 NSCLC cell lines harboring different forms of EGFR.Compounds 7f and7 k exhibited potent and selective activity in inhibition of gefitinib-resistant H1975 cancer cells(IC50;0.45,0.2μmol/L) while were much less active on A549 cancer cells(IC50;52.83,〉100μmol/L).Both compounds could be served as promising lead compounds for further investigation.展开更多
A new epipolythiodioxopiperazine (ETP), asperterzine (1), along with two known analogs, bisdethiobis (methylthio)-acetylaranotin (2) and bisdethiobis(methylthio)-acetylapoaranotin (3), was isolated from th...A new epipolythiodioxopiperazine (ETP), asperterzine (1), along with two known analogs, bisdethiobis (methylthio)-acetylaranotin (2) and bisdethiobis(methylthio)-acetylapoaranotin (3), was isolated from the plant endophytic fungus Aspergillus terreus PR-P-2. The structure elucidation of 1 was accomplished by a combination of spectral methods and electronic circular dichroism (ECD) spectrum. Asperterzine (1) was a symmetric aromatized ETP found as a natural product for the first time. Compounds 2 and 3 showed strong cytotoxicity against HL-60 cell line. The putative biosynthetic pathway of 1 was also detailed in the text.展开更多
文摘Fifty-six compounds have been isolated from Abrus mollis until now,including saponins,steroids,flavonoids and fatty acid,which have the functions of promoting blood circulation to remove blood stasis,protecting the liver and promoting gallbladder,anti-oxidation and enhancing immunity,etc.A.mollis has good therapeutic effects on liver diseases.In this paper,the chemical constituents and pharmacological effects of A.mollis were reviewed in order to provide a reference for the further development.
基金the financial support of the National Natural Science Foundation of China(Grants 21977073)the Liao-ning BaiQianWan Talents Program+2 种基金Liaoning Revitalization Tale nts Programthe program for the innoyative research team of the Ministry of Educationthe program for the Liaoning innovative research team in university.
文摘A gold(Ⅰ)-catalyzed 6-endo-dig cyclization of aromatic 1,5-enynes was developed to synthesize 2-(naphthalen-2-yl)anilines.The functional group tolerance of this cyclization was examined systematically and a possible mechanism was proposed.The derivatization of 2-(naphthalen-2-yl)aniline was carried out to facile access to benzo[α]carbazole,benzo[c,h]cinnoline and dibenzo[i]phenanthridine derivatives in a divergent way.
基金supported by Specialized Research Fund for the Doctoral Program of Higher Education(SRFDP No.20112134120006)
文摘The present study was designed to investigate the chemical constituents of the fruit of Citrus aurantium L.. The compounds were isolated and purified by various chromatographic techniques, and their structures were elucidated on the basis of physicochemical properties and spectral data. Two new phenolic glycosides(compounds 1 and 2) were obtained and identified as 1-O-3, 5-dihydroxyphenyl-(6-O-4-hydroxybenzoyl)-β-D-glucopyranoside(1) and 1-O-3, 5-dihydroxyphenyl-(6-O-3-methoxy-4-hydroxy benzoyl)-β-D-glucopyranoside(2), respectively.
基金supported by grants from Science Foundation of Shenyang Pharmaceutical University(No.QNJJ2014502)
文摘Based on our previous work,a series of hydrazone moiety-bearing aminopyrimidines were synthesized.The compounds were evaluated for inhibitory activities against EGFRT790M/L858 R and antiproliferative activities against H1975 and A549 NSCLC cell lines harboring different forms of EGFR.Compounds 7f and7 k exhibited potent and selective activity in inhibition of gefitinib-resistant H1975 cancer cells(IC50;0.45,0.2μmol/L) while were much less active on A549 cancer cells(IC50;52.83,〉100μmol/L).Both compounds could be served as promising lead compounds for further investigation.
基金supported by the Fund of Natural Science of Liaoning Province(No. 2015020730)supported by Program for Innovative Research Team of the Ministry of EducationProgram for Liaoning Innovative Research Team in University
文摘A new epipolythiodioxopiperazine (ETP), asperterzine (1), along with two known analogs, bisdethiobis (methylthio)-acetylaranotin (2) and bisdethiobis(methylthio)-acetylapoaranotin (3), was isolated from the plant endophytic fungus Aspergillus terreus PR-P-2. The structure elucidation of 1 was accomplished by a combination of spectral methods and electronic circular dichroism (ECD) spectrum. Asperterzine (1) was a symmetric aromatized ETP found as a natural product for the first time. Compounds 2 and 3 showed strong cytotoxicity against HL-60 cell line. The putative biosynthetic pathway of 1 was also detailed in the text.