Breast cancer is one of the leading causes of cancer-related deaths in women worldwide.It is a cancer that originates from the mammary ducts and involves mutations in multiple genes.Recently,the treatment of breast ca...Breast cancer is one of the leading causes of cancer-related deaths in women worldwide.It is a cancer that originates from the mammary ducts and involves mutations in multiple genes.Recently,the treatment of breast cancer has become increasingly challenging owing to the increase in tumor heterogeneity and aggressiveness,which gives rise to therapeutic resistance.Epidemiological,populationbased,and hospital-based case-control studies have demonstrated an association between high intake of certain Allium vegetables and a reduced risk in the development of breast cancer.Diallyl disulfide(DADS)and diallyl trisulfide(DATS)are the main allyl sulfur compounds present in garlic,and are known to exhibit anticancer activity as they interfere with breast cancer cell proliferation,tumor metastasis,and angiogenesis.The present review highlights multidrug resistance mechanisms and their signaling pathways in breast cancer.This review discusses the potential anticancer activities of DADS and DATS,with emphasis on drug resistance in triple-negative breast cancer(TNBC).Understanding the anticancer activities of DADS and DATS provides insights into their potential in targeting drug resistance mechanisms of TNBC,especially in clinical studies.展开更多
Single-phase diluted magnetic systems Zn1-xFexO have been prepared by chemical route. Structural and spectroscopic （UV-Vis and Mossbauer） studies indicate the incorporation of Fe^3＋ ions in the lattice sites. The U...Single-phase diluted magnetic systems Zn1-xFexO have been prepared by chemical route. Structural and spectroscopic （UV-Vis and Mossbauer） studies indicate the incorporation of Fe^3＋ ions in the lattice sites. The UV-Vis results point to a systematic increase in the band gap with increasing Fe doping. The room temperature magnetization of Zni-xFexO indicates a paramagnetic behavior which is in accordance with the Mossbauer results, illustrating quadrupolar doublet. At low temperature, the zero-field-cooled （ZFC） magnetization shows a cusp and this temperature increases systematically with decreasing particle size. The weak exchange bias effect manifested by a M-H loop shift is observed for x = 0.03. This shift is accompanied by the enhancement of coercivity. The dc magnetization results suggest the coexis tence of ferromagnetic and antiferromagnetic exchange interactions for low doping of Fe, i.e., for x = 0.03.展开更多
Objective:To describe the parasitic infestations of Anabas testudineus(A.testudineus)collected from three different fish producing districts of West Bengal state in India.Methods:A total number of 75 specimens of A.te...Objective:To describe the parasitic infestations of Anabas testudineus(A.testudineus)collected from three different fish producing districts of West Bengal state in India.Methods:A total number of 75 specimens of A.testudineus were collected from different floodplain areas of West Bengal,India.These specimens were examined for parasites using established techniques after measuring basic morphometric parameters.Results:A total 165 individual of 20 parasites(13 ectoparasites and 7 endoparasites)belonging to 7 phyla were recorded from 64 infected A.testudineus.Among the observed parasites,8 were protozoan including 3 ciliates;2 monogenic trematodes,2 strigeidid trematodes,1 nematode,3 crustaceans,3 myxozoans and 1 echinorhynchus acanthocephalan parasites.The quantitative abundance of parasites were highest in gill(37%)followed by body outer layer(35%)and intestine(28%).District wise quantitative count of parasites in different investigated organ from A.testudineus revealed that North 24 Parganas is highly infected followed by West Midnapore and East Midnapore.The highest prevalence(%)and mean abundance of parasitic occurrence was observed in North 24 Parganas followed by West Midnapore and East Midnapore.The highest mean intensity was found at West Midnapore followed by North 24 Parganas and East Midnapore.Conclusions:Especially West Bengal state of India,inland culture and capture fishery mainly rural based and operated by poor farmers.Developing right kind of interventions and management practice can prevent adverse impact of diseases and assist poor farmers for sustainable production.展开更多
基金supported by UGC-DAE-CSR,Kolkata(Grant No.:KC/CRS/19/RB-04/1047).
文摘Breast cancer is one of the leading causes of cancer-related deaths in women worldwide.It is a cancer that originates from the mammary ducts and involves mutations in multiple genes.Recently,the treatment of breast cancer has become increasingly challenging owing to the increase in tumor heterogeneity and aggressiveness,which gives rise to therapeutic resistance.Epidemiological,populationbased,and hospital-based case-control studies have demonstrated an association between high intake of certain Allium vegetables and a reduced risk in the development of breast cancer.Diallyl disulfide(DADS)and diallyl trisulfide(DATS)are the main allyl sulfur compounds present in garlic,and are known to exhibit anticancer activity as they interfere with breast cancer cell proliferation,tumor metastasis,and angiogenesis.The present review highlights multidrug resistance mechanisms and their signaling pathways in breast cancer.This review discusses the potential anticancer activities of DADS and DATS,with emphasis on drug resistance in triple-negative breast cancer(TNBC).Understanding the anticancer activities of DADS and DATS provides insights into their potential in targeting drug resistance mechanisms of TNBC,especially in clinical studies.
文摘Single-phase diluted magnetic systems Zn1-xFexO have been prepared by chemical route. Structural and spectroscopic （UV-Vis and Mossbauer） studies indicate the incorporation of Fe^3＋ ions in the lattice sites. The UV-Vis results point to a systematic increase in the band gap with increasing Fe doping. The room temperature magnetization of Zni-xFexO indicates a paramagnetic behavior which is in accordance with the Mossbauer results, illustrating quadrupolar doublet. At low temperature, the zero-field-cooled （ZFC） magnetization shows a cusp and this temperature increases systematically with decreasing particle size. The weak exchange bias effect manifested by a M-H loop shift is observed for x = 0.03. This shift is accompanied by the enhancement of coercivity. The dc magnetization results suggest the coexis tence of ferromagnetic and antiferromagnetic exchange interactions for low doping of Fe, i.e., for x = 0.03.
文摘Objective:To describe the parasitic infestations of Anabas testudineus(A.testudineus)collected from three different fish producing districts of West Bengal state in India.Methods:A total number of 75 specimens of A.testudineus were collected from different floodplain areas of West Bengal,India.These specimens were examined for parasites using established techniques after measuring basic morphometric parameters.Results:A total 165 individual of 20 parasites(13 ectoparasites and 7 endoparasites)belonging to 7 phyla were recorded from 64 infected A.testudineus.Among the observed parasites,8 were protozoan including 3 ciliates;2 monogenic trematodes,2 strigeidid trematodes,1 nematode,3 crustaceans,3 myxozoans and 1 echinorhynchus acanthocephalan parasites.The quantitative abundance of parasites were highest in gill(37%)followed by body outer layer(35%)and intestine(28%).District wise quantitative count of parasites in different investigated organ from A.testudineus revealed that North 24 Parganas is highly infected followed by West Midnapore and East Midnapore.The highest prevalence(%)and mean abundance of parasitic occurrence was observed in North 24 Parganas followed by West Midnapore and East Midnapore.The highest mean intensity was found at West Midnapore followed by North 24 Parganas and East Midnapore.Conclusions:Especially West Bengal state of India,inland culture and capture fishery mainly rural based and operated by poor farmers.Developing right kind of interventions and management practice can prevent adverse impact of diseases and assist poor farmers for sustainable production.
