Nigella sativa (N. sativa) decreases DNA damage and thereby prevents initiation of carcinogenesis in colonic tissue secondary to exposure to toxic agents such as azoxymethane. N. sativa is of immense therapeutic benef...Nigella sativa (N. sativa) decreases DNA damage and thereby prevents initiation of carcinogenesis in colonic tissue secondary to exposure to toxic agents such as azoxymethane. N. sativa is of immense therapeutic benefit in diabetic individuals and those with glucose intolerance as it accentuates glucose-induced secretion of insulin besides having a negative impact on glucose absorption from the intestinal mucosa. N. sativa administration protects hepatic tissue from deleterious effects of toxic metals such as lead, and attenuates hepatic lipid peroxidation following exposure to chemicals such as carbon tetrachloride.展开更多
The recent article by Zhou et al was highly interesting and thought provoking. The authors have clearly shown that triptolide administration is associated with upregulation of the Bax gene, resulting in an attenuating...The recent article by Zhou et al was highly interesting and thought provoking. The authors have clearly shown that triptolide administration is associated with upregulation of the Bax gene, resulting in an attenuating effect on cell growth in gastrointestinal malignancies such as pancreatic carcinomas. The article by Zhou et al is all the more important because it highlights the rapidly increasing role of triplodide in the management of systemic malignancies. For instance, triptolide acts on the PI3K/Akt/NF-κB pathway, thereby enhancing apoptosis secondary to the administration of bortezomib in multiple myeloma cells. Similar synergisms are seen when triptolide is administered along with 5-fluoruracil for the management of colonic carcinomas. Similarly, triptolide causes down-regulation of the Bcl-2 gene, resulting in control of cell growth in tumors, such as glioblastoma multiformes.展开更多
In comparison to polyethylene glycol,lubiprostone offers other advantages and is increasingly being used as an adjunctive agent in diagnostic as well as management strategies not only in gastroenterology, but in other...In comparison to polyethylene glycol,lubiprostone offers other advantages and is increasingly being used as an adjunctive agent in diagnostic as well as management strategies not only in gastroenterology, but in other fields.For instance,lubiprostone exerts beneficial effects in cystic fibrosis tissues.It augmernts the chloride secretion in these cells by activating non-cystic fibrosis transmembrane regulator(CFTR) secretion of chloride by afflicted respiratory epithelia. Lubiprostone also seems to improve visualization of the gastrointestinal tract during procedures such as colonoscopy.This is especially true if the lubiprostone is administered prior to bowel cleansing with agents such as polyethylene glycol electrolyte(PEG-E). Lubiprostone also enhances and stimulates contraction in colonic as well as gastric muscles and may thus further contribute as a prokinetic agent.Besides these effects,lubiprostone also causes hyperpolarization in other tissues such as uterine muscle cells.This may prove to be of significant clinical benefit in the management of uterine pathologies in the near future.展开更多
“可收藏+开箱”玩具是年初举行的北美国际玩具展上发布的玩具潮流之一。开箱(指拆开产品的全新包装,探索产品款式、功能体验的过程。)潮流主要由国外社交视频网站YouTube上的网络红人带起,结合去年火爆的可收藏玩具热,在玩具业掀起的...“可收藏+开箱”玩具是年初举行的北美国际玩具展上发布的玩具潮流之一。开箱(指拆开产品的全新包装,探索产品款式、功能体验的过程。)潮流主要由国外社交视频网站YouTube上的网络红人带起,结合去年火爆的可收藏玩具热,在玩具业掀起的一阵风潮。去年,全球可收藏玩具销售额增长了14%,达到39亿美元。美国玩具协会的首席潮流专家Adrienne Appell表示:“在展会前后了解了过千件展品后,我们发现,玩具商在原有的经典玩法上加入更多惊喜元素,以达到吸引儿童重复购买消费的“Big Reveal”Trend Takes Over the Toy Aisle“可收藏+开箱”作者美国玩具协会Kristin Morency Goldman编译张芷盈目的。2018年‘可收藏+开箱’潮流包括常规和罕见的可收藏玩具、盲盒包装的玩具、具有开箱元素的产品,以及具有变形元素的产品。”展开更多
To the editor:I read with great interest the recent article by Li,et al.The authors have clearly shown that tanshinoneⅡA inhibits myocardial cell hypertrophy induced by angiotensinⅡby inhibiting p-ERK1/2 expression....To the editor:I read with great interest the recent article by Li,et al.The authors have clearly shown that tanshinoneⅡA inhibits myocardial cell hypertrophy induced by angiotensinⅡby inhibiting p-ERK1/2 expression.Interestingly,tanshinoneⅡA also has potent anti-carcinogenic properties.As a result,tanshinoneⅡA is rapidly emerging as an agent with considerable promise in the field of oncology.展开更多
文摘Nigella sativa (N. sativa) decreases DNA damage and thereby prevents initiation of carcinogenesis in colonic tissue secondary to exposure to toxic agents such as azoxymethane. N. sativa is of immense therapeutic benefit in diabetic individuals and those with glucose intolerance as it accentuates glucose-induced secretion of insulin besides having a negative impact on glucose absorption from the intestinal mucosa. N. sativa administration protects hepatic tissue from deleterious effects of toxic metals such as lead, and attenuates hepatic lipid peroxidation following exposure to chemicals such as carbon tetrachloride.
文摘The recent article by Zhou et al was highly interesting and thought provoking. The authors have clearly shown that triptolide administration is associated with upregulation of the Bax gene, resulting in an attenuating effect on cell growth in gastrointestinal malignancies such as pancreatic carcinomas. The article by Zhou et al is all the more important because it highlights the rapidly increasing role of triplodide in the management of systemic malignancies. For instance, triptolide acts on the PI3K/Akt/NF-κB pathway, thereby enhancing apoptosis secondary to the administration of bortezomib in multiple myeloma cells. Similar synergisms are seen when triptolide is administered along with 5-fluoruracil for the management of colonic carcinomas. Similarly, triptolide causes down-regulation of the Bcl-2 gene, resulting in control of cell growth in tumors, such as glioblastoma multiformes.
文摘In comparison to polyethylene glycol,lubiprostone offers other advantages and is increasingly being used as an adjunctive agent in diagnostic as well as management strategies not only in gastroenterology, but in other fields.For instance,lubiprostone exerts beneficial effects in cystic fibrosis tissues.It augmernts the chloride secretion in these cells by activating non-cystic fibrosis transmembrane regulator(CFTR) secretion of chloride by afflicted respiratory epithelia. Lubiprostone also seems to improve visualization of the gastrointestinal tract during procedures such as colonoscopy.This is especially true if the lubiprostone is administered prior to bowel cleansing with agents such as polyethylene glycol electrolyte(PEG-E). Lubiprostone also enhances and stimulates contraction in colonic as well as gastric muscles and may thus further contribute as a prokinetic agent.Besides these effects,lubiprostone also causes hyperpolarization in other tissues such as uterine muscle cells.This may prove to be of significant clinical benefit in the management of uterine pathologies in the near future.
文摘“可收藏+开箱”玩具是年初举行的北美国际玩具展上发布的玩具潮流之一。开箱(指拆开产品的全新包装,探索产品款式、功能体验的过程。)潮流主要由国外社交视频网站YouTube上的网络红人带起,结合去年火爆的可收藏玩具热,在玩具业掀起的一阵风潮。去年,全球可收藏玩具销售额增长了14%,达到39亿美元。美国玩具协会的首席潮流专家Adrienne Appell表示:“在展会前后了解了过千件展品后,我们发现,玩具商在原有的经典玩法上加入更多惊喜元素,以达到吸引儿童重复购买消费的“Big Reveal”Trend Takes Over the Toy Aisle“可收藏+开箱”作者美国玩具协会Kristin Morency Goldman编译张芷盈目的。2018年‘可收藏+开箱’潮流包括常规和罕见的可收藏玩具、盲盒包装的玩具、具有开箱元素的产品,以及具有变形元素的产品。”
文摘To the editor:I read with great interest the recent article by Li,et al.The authors have clearly shown that tanshinoneⅡA inhibits myocardial cell hypertrophy induced by angiotensinⅡby inhibiting p-ERK1/2 expression.Interestingly,tanshinoneⅡA also has potent anti-carcinogenic properties.As a result,tanshinoneⅡA is rapidly emerging as an agent with considerable promise in the field of oncology.
