Aminoalkyl methacrylate copolymer,Eudragit?E PO(EPO),has been used as a polymeric carrier for solid dispersion to significantly enhance the drug dissolution.However,the improvement of the drug dissolution by the drug/...Aminoalkyl methacrylate copolymer,Eudragit?E PO(EPO),has been used as a polymeric carrier for solid dispersion to significantly enhance the drug dissolution.However,the improvement of the drug dissolution by the drug/EPO solid dispersion is limited only in acidic solution due to the pHdependant solubility of basic EPO with its tertiary amino group.We previously reported that the blending of saccharin(SAC)in the drug/EPO solid dispersion led to the supersaturation formation of drug even at neutral pH[1].展开更多
Liposomes, closed vesicles composed of lipid bilayers, have been widely used as pharmaceutical carriers. Liposomal formulations containing doxorubicin (DOX) of an anticancer drug are developed to reduce toxic side eff...Liposomes, closed vesicles composed of lipid bilayers, have been widely used as pharmaceutical carriers. Liposomal formulations containing doxorubicin (DOX) of an anticancer drug are developed to reduce toxic side effects and to improve drug accumulation at tumor tissues. An encapsulation of DOX into the inner water phase of liposomes results in the formations of fibrous DOX bundles and the elongation of the liposomes [1].In this study, atomic force microscopy (AFM).展开更多
文摘Aminoalkyl methacrylate copolymer,Eudragit?E PO(EPO),has been used as a polymeric carrier for solid dispersion to significantly enhance the drug dissolution.However,the improvement of the drug dissolution by the drug/EPO solid dispersion is limited only in acidic solution due to the pHdependant solubility of basic EPO with its tertiary amino group.We previously reported that the blending of saccharin(SAC)in the drug/EPO solid dispersion led to the supersaturation formation of drug even at neutral pH[1].
文摘Liposomes, closed vesicles composed of lipid bilayers, have been widely used as pharmaceutical carriers. Liposomal formulations containing doxorubicin (DOX) of an anticancer drug are developed to reduce toxic side effects and to improve drug accumulation at tumor tissues. An encapsulation of DOX into the inner water phase of liposomes results in the formations of fibrous DOX bundles and the elongation of the liposomes [1].In this study, atomic force microscopy (AFM).
